Homeostatic Plasticity in Epilepsy

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

(2020) Gaia Colasante et al.   BRAIN

Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment

(2020) Alejandro Pan-Vazquez et al.   NEURON

M-Current Inhibition in Hippocampal Excitatory Neurons Triggers Intrinsic and Synaptic Homeostatic Responses at Different Temporal Scales

(2020) Jonathan Lezmy et al.   JOURNAL OF NEUROSCIENCE

Identification of epileptic brain states by dynamic functional connectivity analysis of simultaneous EEG-fMRI: a dictionary learning approach

(2019) Rodolfo Abreu et al.   Scientific Reports

Epilepsy gene therapy using an engineered potassium channel

(2019) Albert Snowball et al.   JOURNAL OF NEUROSCIENCE

Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy

(2019) Alexandra S Agostinho et al.   EMBO Molecular Medicine

Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

(2019) Peter James Morgan et al.   eLife

Mechanisms of Homeostatic Synaptic Plasticity in vivo

(2019) Hey-Kyoung Lee et al.   Frontiers in Cellular Neuroscience

Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

(2019) Jenny Wickham et al.   Scientific Reports

Biochemical autoregulatory gene therapy for focal epilepsy

(2018) Andreas Lieb et al.   NATURE MEDICINE

Gene therapy and editing: Novel potential treatments for neuronal channelopathies

(2018) R.C. Wykes et al.   NEUROPHARMACOLOGY

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

OUP accepted manuscript

(2018)   BRAIN

Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons

(2018) Wenqin Hu et al.   NEURON

Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses

(2018) Takafumi Miki et al.   Nature Communications

Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model

(2018) Bao-Luen Chang et al.   Disease Models & Mechanisms

Homeostatic synaptic plasticity as a metaplasticity mechanism — a molecular and cellular perspective

(2018) Jie Li et al.   CURRENT OPINION IN NEUROBIOLOGY

Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis

(2017) Bridget N. Queenan et al.   EPILEPSIA

EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice

(2017) Xin Xu et al.   JOURNAL OF PHYSIOLOGY-LONDON

REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity

(2017) F. Pecoraro-Bisogni et al.   MOLECULAR NEUROBIOLOGY

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss

(2017) Samuel J. Barnes et al.   NEURON

Quantal Fluctuations in Central Mammalian Synapses: Functional Role of Vesicular Docking Sites

(2017) Camila Pulido et al.   PHYSIOLOGICAL REVIEWS

Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs

(2016) Winnie Wefelmeyer et al.   TRENDS IN NEUROSCIENCES

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks

(2015) Eleonora Vannini et al.   Brain Structure & Function

Homeostatic regulation of h-conductance controls intrinsic excitability and stabilizes the threshold for synaptic modification in CA1 neurons

(2015) Célia Gasselin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vesicular Release Statistics and Unitary Postsynaptic Current at Single GABAergic Synapses

(2015) Camila Pulido et al.   NEURON

Ultrastructural and functional fate of recycled vesicles in hippocampal synapses

(2015) Stephanie A. Rey et al.   Nature Communications

Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity

(2015) Hiroshi Kuba et al.   Nature Communications

Operational hub cells: a morpho-physiologically diverse class of GABAergic neurons united by a common function

(2014) Rosa Cossart   CURRENT OPINION IN NEUROBIOLOGY

The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons

(2014) Yimy Amarillo et al.   JOURNAL OF NEUROPHYSIOLOGY

Gene therapy in epilepsy—is it time for clinical trials?

(2014) Dimitri M. Kullmann et al.   Nature Reviews Neurology

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy

(2013) Florian Kirchheim et al.   Frontiers in Cellular Neuroscience

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Tetanus neurotoxin-induced epilepsy in mouse visual cortex

(2012) Marco Mainardi et al.   EPILEPSIA

A Preferentially Segregated Recycling Vesicle Pool of Limited Size Supports Neurotransmission in Native Central Synapses

(2012) Vincenzo Marra et al.   NEURON

Readily releasable pool of synaptic vesicles measured at single synaptic contacts

(2012) F. F. Trigo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1−/y Mouse Model of Fragile X Syndrome

(2012) Darrin H. Brager et al.   Cell Reports

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

(2011) Shawn McClelland et al.   ANNALS OF NEUROLOGY

Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model

(2011) Xiao-Ling Hu et al.   CEREBRAL CORTEX

PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down

(2011) Q. Sun et al.   JOURNAL OF NEUROSCIENCE

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

Increased seizure severity and seizure-related death in mice lacking HCN1 channels

(2010) Bina Santoro et al.   EPILEPSIA

Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic pre-synaptic terminals

(2010) Hong Lou et al.   JOURNAL OF NEUROCHEMISTRY

Spike-Time Precision and Network Synchrony Are Controlled by the Homeostatic Regulation of the D-Type Potassium Current

(2010) R. H. Cudmore et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability

(2010) Matthew S. Grubb et al.   NATURE

Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis

(2009) Z. Huang et al.   JOURNAL OF NEUROSCIENCE

HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K+ channels

(2009) Meena S George et al.   NATURE NEUROSCIENCE

The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family

(2009) S. Gillies et al.   NEUROPEPTIDES

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

(2008) Francesco Noè et al.   BRAIN

Carboxypeptidase E Cytoplasmic Tail-Driven Vesicle Transport Is Key for Activity-Dependent Secretion of Peptide Hormones

(2008) Joshua J. Park et al.   MOLECULAR ENDOCRINOLOGY

h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy

(2008) Béatrice Marcelin et al.   NEUROBIOLOGY OF DISEASE

Upregulated H-Current in hyperexcitable CA1 dendrites after febrile seizures

(2008) Jonas Dyhrfjeld-Johnsen   Frontiers in Cellular Neuroscience