Article
Chemistry, Multidisciplinary
Bin Zhao, Zhili Ma, Shuaishuai Ding, Yuhua Cao, Jiangfeng Du, Lijuan Zeng, Yunping Hu, Jingrong Zhou, Xiao Zhang, Xiu-wu Bian, Gan Tian
Summary: Nanomedicine-based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid tumor ablation, which holds great hope for the refractory and recurrent cancers, such as triple negative breast cancer (TNBC). The single-component MnWO4 is first reported as a new kind of Fenton-like agent yet radiosensitizer for TNBC treatment undergoing the synergistic CDT/RT mechanism. Mn-triggered chemodynamic effect delays RT-induced DNA damage repair and sorts cell cycles distribution toward radiosensitive phases, while W-mediated radiosensitization improves the tumoral H2O2 overexpression to enhance CDT, remarkably amplifying of the intracellular oxidative stress to boost 4T1 cell apoptosis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Zakia Akter, Fabiha Zaheen Khan, Md. Asaduzzaman Khan
Summary: This article reviews the mechanism of action of gold nanoparticles (AuNPs) and their application in enhancing therapeutics against triple-negative breast cancer (TNBC). Various studies indicate that AuNPs can improve drug bioavailability, site-specific drug delivery, and the efficacy of chemotherapy, radiotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT), as well as modulate gene expression. The mechanistic actions of AuNPs in inhibiting cell proliferation, progression, and metastasis have been demonstrated in vitro and in vivo studies, making them a promising approach for TNBC therapeutics.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Xiao Qian Wang, Esther Danenberg, Chiun-Sheng Huang, Daniel Egle, Maurizio Callari, Begona Bermejo, Matteo Dugo, Claudio Zamagni, Marc Thill, Anton Anton, Stefania Zambelli, Stefania Russo, Eva Maria Ciruelos, Richard Greil, Balazs Gyorffy, Vladimir Semiglazov, Marco Colleoni, Catherine M. Kelly, Gabriella Mariani, Lucia Del Mastro, Olivia Biasi, Robert S. Seitz, Pinuccia Valagussa, Giuseppe Viale, Luca Gianni, Giampaolo Bianchini, H. Raza Ali
Summary: Imaging mass cytometry reveals that the multicellular dynamics in triple-negative breast cancer treated with immune checkpoint blockade (ICB) play a crucial role in determining treatment response. Key factors such as cell phenotype, activation state, and spatial location influence the effectiveness of ICB. By understanding the impact of multicellular organization, we can better guide adaptive therapy and achieve precision immuno-oncology.
Article
Materials Science, Biomaterials
Simin Chen, Jialong Fan, Feng Xiao, Yan Qin, Ying Long, Liqin Yuan, Bin Liu
Summary: In this study, MnO2-coated Prussian blue nanocomplexes (PM NPs) were designed as O-2 suppliers and GSH depletion agents to reprogram the tumor microenvironment (TME). The prepared PMRCR NPs exhibited excellent photothermal performance and enhanced photodynamic/photothermal therapy (PDT/PTT) efficacy both in vitro and in vivo. This work provides a promising strategy to enhance the antitumor efficacy of PDT/PTT by developing TME-reprogrammed multifunctional nanocomplexes.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Xiang Li, Mei He, Qinghao Zhou, Debabrata Dutta, Nannan Lu, Shikuo Li, Zhishen Ge
Summary: In this study, glucose oxidase-encapsulated mesoporous hollow Co9S8 nanoreactors (GOx@PCoS) were constructed for synergistic multimodal therapy of tumors. GOx@PCoS depleted GSH, produced H2O2, and exhibited photothermal and photodynamic effects to enhance the anticancer efficacy. It also served as an MRI contrast agent for monitoring the therapeutic performance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Rui Han, Hongxing Yang, Changquan Ling, Lingeng Lu
Summary: In this study, the therapeutic potential of Tiliroside (TS) in triple negative breast cancer (TNBC) was evaluated. The results showed that TS exhibited anti-cancer activity, reduced tumor burden, and improved survival rate in TNBC. Additionally, TS acted as a CAXII inhibitor to suppress TNBC progression.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Yufei Liu, Yao Qi, Chen Chen, Yincheng Jin, Shi Du, Jianan Qiao, Jing Yao
Summary: In this study, a nano-sensor system, Van-ICG@PLT, was designed to deliver drugs and phototherapy to surgical incisions, effectively eliminating residual tumor cells and bacterial infections. The nano-sensor selectively accumulated at the surgical wound, exhibiting significant cytotoxicity against tumor cells and inhibiting bacterial growth.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ebtihal H. Mustafa, Geraldine Laven-Law, Zoya Kikhtyak, Van Nguyen, Simak Ali, Alex A. Pace, Richard Iggo, Alemwork Kebede, Ben Noll, Shudong Wang, Jean M. Winter, Amy R. Dwyer, Wayne D. Tilley, Theresa E. Hickey
Summary: Targeting transcription via CDK9 could be a potential therapeutic strategy for TNBC. Preclinical studies showed that a selective CDK9 inhibitor, CDDD11-8, effectively inhibited proliferation, induced cell cycle arrest, and increased apoptosis of TNBC cells in vitro and in vivo, without apparent toxicity to normal tissues.
Article
Immunology
Jianquan Yang, Wen Guo, Rong Huang, Jiaojiao Bian, Siqi Zhang, Ting Wei, Chuanshi He, Ziyue Hu, Juan Li, Chunyang Zhou, Man Lu
Summary: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with limited treatment options and poor prognosis. This study developed albumin-based nanospheres loaded with a photosensitizer and cGAS-STING agonists, which showed effectiveness in inducing pyroptosis, a form of immunogenic cell death, and activating the cGAS-STING signaling pathway. In vivo experiments demonstrated that this novel strategy inhibited tumor growth and enhanced the efficacy of anti-PD-L1 antibody treatment in TNBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Medicine, General & Internal
Ryan Sun, Lee-Jen Wei
Summary: This article discusses the clinical benefits of pembrolizumab combined with chemotherapy in patients with triple-negative breast cancer. The authors suggest that both hazard values and ratios should be considered when evaluating clinical benefits.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Alexander S. Roesler, Smriti Malasi, Lori Koslosky, Peter Hartmayer, Tammey J. Naab, Jodi M. Carter, David Zahrieh, David Hillman, Roberto A. Leon-Ferre, Fergus J. Couch, Matthew P. Goetz, Karen S. Anderson, Barbara A. Pockaj, Michael T. Barrett
Summary: We investigated the prevalence, prognostic value, and enrichment by chemotherapy of the PDJ amplicon in TNBC. Our findings demonstrate that the prevalence of PDJ amplicons in TNBC varies extensively and is associated with poor clinical outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Jinxian Wu, Shanyong Wang, Shanshan Liu, Fang Liu, Feifan Zhou
Summary: This study developed a self-assembly nanoparticle using glycated chitosan for synergistic treatment of triple-negative breast cancer. The nanoparticle enabled direct elimination of primary tumors and suppression of distant tumors, while enhancing tumor immunogenicity and infiltration of CD8(+) T cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Megan N. Dang, Carolina Gomez Casas, Emily S. Day
Summary: The introduction of miR-34a into TNBC cells through miR-34a/NS holds promise for precise gene regulation, with the potential to improve patient prognosis in an aggressive disease. This nanotechnology-based approach demonstrates efficient regulation of downstream miR-34a targets to reduce TNBC cell viability, proliferation, and migration. Further research shows that pulsed near-infrared light can effectively release miRNA from the nanoshells, with the released miR-34a being as potent as transfected miR-34a.
Review
Oncology
Sundee Dees, Rajkumar Ganesan, Sanjaya Singh, Iqbal S. Grewal
Summary: TNBC is an aggressive subtype of breast cancer lacking hormone receptors and HER2 expression, with poor prognosis. Current treatment modalities include chemotherapy, radiation, and surgery. Bispecific antibody-based therapies for TNBC are gaining attention, with a focus on novel antibodies and emerging targets for future development.
Editorial Material
Chemistry, Multidisciplinary
Alexandre de Nonneville, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier, Francois Bertucci
Summary: This study demonstrates the critical role of WEE1 in triple negative breast cancer, its pejorative prognostic value, and its correlation with biomarkers of sensitivity to WEE1 inhibitors.
Article
Chemistry, Multidisciplinary
Hongping Xia, Fangyuan Li, Wooram Park, Shuaifei Wang, Youngjin Jang, Yang Du, Seungmin Baik, Soojeong Cho, Taegyu Kang, Dong-Hyun Kim, Daishun Ling, Kam Man Hui, Taeghwan Hyeon
ACS CENTRAL SCIENCE
(2016)
Article
Chemistry, Multidisciplinary
Ling Chen, Yang Du, Kai Zhang, Zeyu Liang, Jinquan Li, Hao Yu, Rong Ren, Jin Feng, Zhiming Jin, Fangyuan Li, Jihong Sun, Min Zhou, Qinggang He, Xiaolian Sun, Hong Zhang, Mei Tian, Daishun Ling
Article
Chemistry, Multidisciplinary
Fangyuan Li, Yang Du, Jianan Liu, Heng Sun, Jin Wang, Ruiqing Li, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling
ADVANCED MATERIALS
(2018)
Article
Engineering, Biomedical
Bao-Ping Tian, Fangyuan Li, Ruiqing Li, Xi Hu, Tian-Wen Lai, Jingxiong Lu, Yun Zhao, Yang Du, Zeyu Liang, Chen Zhu, Wei Shao, Wen Li, Zhi-Hua Chen, Xiaolian Sun, Xiaoyuan Chen, Songmin Ying, Daishun Ling, Huahao Shen
Article
Engineering, Biomedical
Haibin Wu, Fangyuan Li, Shuaifei Wang, Jingxiong Lu, Jinquan Li, Yang Du, Xiaolian Sun, Xiaoyuan Chen, Jianqing Gao, Daishun Ling
Article
Nanoscience & Nanotechnology
Jianan Liu, Fangyuan Li, Yi Wang, Limin Pan, Peihua Lin, Bo Zhang, Yanrong Zheng, Yingwei Xu, Hongwei Liao, Giho Ko, Fan Fei, Cenglin Xu, Yang Du, Kwangsoo Shin, Dokyoon Kim, Sung-Soo Jang, Hee Jung Chung, He Tian, Qi Wang, Wei Guo, Jwa-Min Nam, Zhong Chen, Taeghwan Hyeon, Daishun Ling
NATURE NANOTECHNOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Yang Du, Zheng Chen, Ji Young Lee, Peihua Lin, Fan Xia, Yunan Guan, Fangyuan Li, Daishun Ling
Summary: Theranostic nanosystems integrating diagnosis and therapy are gaining attention for personalized medicine. Mesoporous silica nanoparticles are ideal for controlled assembly of functional nanomaterials to fabricate self-assembled theranostic nanomedicines. Strategies for MSN-templated nanomedicines with unique heterostructures are discussed, highlighting challenges in clinical translation.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sadia Nadeem, Chuang Yang, Yang Du, Fangyuan Li, Zheng Chen, Yan Zhou, Ji Young Lee, Qiang Ding, Daishun Ling
Summary: The study presents a virus-spike tumor-activatable pyroptotic agent for cancer-specific therapy, which can induce pyroptosis in tumor cells. This agent can accumulate in tumors after systemic administration and be degraded by intracellular glutathione to activate inflammasomes and lead to pyroptotic cell death. This structure-dependent and tumor intracellular GSH activatable pyroptotic agent represents a novel paradigm for cancer-specific pyroptotic nanomedicine development.
Article
Chemistry, Multidisciplinary
Jiaojiao Zhang, Bingqiang Gao, Binglin Ye, Zhongquan Sun, Zhefeng Qian, Lisha Yu, Yanli Bi, Lie Ma, Yuan Ding, Yang Du, Weilin Wang, Zhengwei Mao
Summary: This study discovers that polyphenols such as tannic acid (TA) can target polyphenol/antioxidase complexes to mitochondria, effectively scavenging excess mtROS and inhibiting inflammasome-mediated pyroptosis. The complexes, referred to as TSC, maintain superior efficacy compared to the gold standard drug N-acetylcysteine in pyroptosis-related hepatitis mouse models. This research opens up new possibilities for targeting mitochondrial oxidative stress to treat inflammatory diseases.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Yang Du, Xiaohui Qian, Fenghao Lin, Bingqiang Gao, Weili Wang, Huang Yang, Weilin Wang, Yuan Ding
Summary: In this study, a biomimetic photothermal nanoplatform Au@Fe-PM was developed for targeted remodeling of tumor-associated macrophages (TAMs) to enhance the antitumor immune response of photothermal therapy (PTT). The Au nanorods served as photothermal agents to induce immunogenic cell death in tumor cells. The ferric hydroxide shell coated on Au nanorods released iron ions to repolarize TAMs into a tumoricidal phenotype. Additionally, the surface decoration of platelet membranes enhanced the tumor targeting ability of the biomimetic nanoplatform. Under NIR-II laser irradiation, Au@Fe-PM showed significantly higher inhibitory effects on tumor growth compared to conventional PTT, with a 50% complete remission rate.
ACTA BIOMATERIALIA
(2023)