Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach
Authors
Keywords
-
Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 100, Issue 3, Pages 295-304
Publisher
Wiley
Online
2016-06-06
DOI
10.1002/cpt.407
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions
- (2015) Ruben de Kanter et al. CLINICAL PHARMACOKINETICS
- Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial
- (2015) Jacek Kubica et al. EUROPEAN HEART JOURNAL
- Predicting Drug-Drug Interactions Involving Multiple Mechanisms Using Physiologically Based Pharmacokinetic Modeling: A Case Study With Ruxolitinib
- (2015) JG Shi et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration
- (2014) Christian Wagner et al. CLINICAL PHARMACOKINETICS
- Simultaneous LC–MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma
- (2014) Marija Bosilkovska et al. Bioanalysis
- Pharmacokinetic Interaction Between Prasugrel and Ritonavir in Healthy Volunteers
- (2013) Virginie Ancrenaz et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Potent P2Y12 receptor inhibitors in patients with acute coronary syndrome
- (2013) D. Sibbing et al. Hamostaseologie
- Safety, tolerability, pharmacokinetics and pharmacodynamics of high single-ascending doses of ticagrelor in healthy volunteers
- (2013) Renli Teng et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- A patient with HIV and tuberculosis with diminished clopidogrel response
- (2013) Nicole L Metzger et al. INTERNATIONAL JOURNAL OF STD & AIDS
- Mechanisms of Pharmacokinetic Enhancement Between Ritonavir and Saquinavir; Micro/Small Dosing Tests Using Midazolam (CYP3A4), Fexofenadine (p-Glycoprotein), and Pravastatin (OATP1B1) as Probe Drugs
- (2013) Ichiro Ieiri et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding
- (2013) Udaya S. Tantry et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects
- (2012) Mikko T. Holmberg et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects
- (2012) Renli Teng et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Monitoring of antiplatelet therapy
- (2011) H. Seidel et al. Hamostaseologie
- Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug–drug interaction in HIV patients
- (2011) Youssef Daali et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Vectorial Transport of Fexofenadine across Caco-2 Cells: Involvement of Apical Uptake and Basolateral Efflux Transporters
- (2011) Xin Ming et al. MOLECULAR PHARMACEUTICS
- Adenosine release: A potential explanation for the benefits of ticagrelor in the PLATelet Inhibition and Clinical Outcomes trial?
- (2010) Victor L. Serebruany AMERICAN HEART JOURNAL
- Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
- (2010) Alexander Jetter et al. ANTIVIRAL THERAPY
- Clopidogrel response: Head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting
- (2010) Thomas Cuisset et al. Archives of Cardiovascular Diseases
- Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers
- (2010) Kathleen Butler et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics
- (2010) D. Zhou et al. DRUG METABOLISM AND DISPOSITION
- Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects
- (2010) R. Teng et al. DRUG METABOLISM AND DISPOSITION
- Variability in drug metabolizing enzyme activity in HIV-infected patients
- (2010) Amanda E. Jones et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y12 receptor antagonist, in healthy subjects
- (2010) Renli Teng et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- pH Dependence of Organic Anion-Transporting Polypeptide 2B1 in Caco-2 Cells: Potential Role in Antiretroviral Drug Oral Bioavailability and Drug-Drug Interactions
- (2010) O. Kis et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation
- (2010) Audrey Bidet et al. PLATELETS
- Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1
- (2010) P. Annaert et al. XENOBIOTICA
- Cardiovascular Death and Nonfatal Myocardial Infarction in Acute Coronary Syndrome Patients Receiving Coronary Stenting Are Predicted by Residual Platelet Reactivity to ADP Detected by a Point-of-Care Assay
- (2009) Rossella Marcucci et al. CIRCULATION
- Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease
- (2009) Paul A. Gurbel et al. CIRCULATION
- A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates
- (2009) Masoud Jamei et al. Drug Metabolism and Pharmacokinetics
- Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation
- (2008) Matthew J. Price et al. EUROPEAN HEART JOURNAL
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started