Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
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Title
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
Authors
Keywords
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Journal
Science Translational Medicine
Volume 12, Issue 549, Pages eaay6570
Publisher
American Association for the Advancement of Science (AAAS)
Online
2020-06-25
DOI
10.1126/scitranslmed.aay6570
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Note: Only part of the references are listed.- Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids
- (2019) Behzad Javaheri et al. AMERICAN JOURNAL OF PATHOLOGY
- Bone metabolism markers are associated with neck circumference in adult Arab women
- (2019) R.S. Albassam et al. OSTEOPOROSIS INTERNATIONAL
- Human Genetics and Drug Development
- (2019) Michael V. Holmes NEW ENGLAND JOURNAL OF MEDICINE
- Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- (2019) Laura M. Huckins et al. NATURE GENETICS
- Osteoporosis
- (2019) Juliet E Compston et al. LANCET
- Abundant associations with gene expression complicate GWAS follow-up
- (2019) Boxiang Liu et al. NATURE GENETICS
- Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
- (2019) Jie Zheng et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Genetically regulated gene expression underlies lipid traits in Hispanic cohorts
- (2019) Angela Andaleon et al. PLoS One
- RoB 2: a revised tool for assessing risk of bias in randomised trials
- (2019) Jonathan A C Sterne et al. BMJ-British Medical Journal
- Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis
- (2018) Weiyuan Ye et al. BONE
- A Phase 3 Randomized Placebo-controlled Trial to Evaluate Efficacy and Safety of Romosozumab in Men With Osteoporosis
- (2018) E Michael Lewiecki et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models
- (2018) Aimy Sebastian et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
- (2018) Rainer Malik et al. NATURE GENETICS
- Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
- (2018) Kaur Alasoo et al. NATURE GENETICS
- Sclerostin in chronic kidney disease–mineral bone disorder think first before you block it!
- (2018) Vincent M Brandenburg et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Circulating levels of sclerostin are associated with cardiovascular mortality
- (2018) Cristina Novo-Rodríguez et al. PLoS One
- Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference
- (2018) Laura J. Corbin et al. Nature Communications
- Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- (2018) Neil M Davies et al. BMJ-British Medical Journal
- Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- (2018) Neil M Davies et al. BMJ-British Medical Journal
- Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults
- (2018) Iona Y. Millwood et al. JAMA Cardiology
- Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies
- (2018) Stephen Burgess et al. JAMA Cardiology
- Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
- (2018) Sara L Pulit et al. HUMAN MOLECULAR GENETICS
- Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
- (2018) Jonas B. Nielsen et al. NATURE GENETICS
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- (2018) Evangelos Evangelou et al. NATURE GENETICS
- Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
- (2018) Katerina Trajanoska et al. BMJ-British Medical Journal
- Serum levels of sclerostin as a potential biomarker in central arterial stiffness among hypertensive patients
- (2018) Yu-Chi Chang et al. BMC Cardiovascular Disorders
- The UK Biobank resource with deep phenotyping and genomic data
- (2018) Clare Bycroft et al. NATURE
- An atlas of genetic influences on osteoporosis in humans and mice
- (2018) John A. Morris et al. NATURE GENETICS
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study
- (2018) Mona Kamal Saadeldin et al. PLoS One
- Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke
- (2018) K. Mathold et al. PLoS One
- Phenome-wide association studies across large population cohorts support drug target validation
- (2018) Dorothée Diogo et al. Nature Communications
- Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned
- (2017) Matthew T Drake et al. ENDOCRINE REVIEWS
- How to use Mendelian randomization to anticipate the results of randomized trials
- (2017) Brian A Ference EUROPEAN HEART JOURNAL
- Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
- (2017) Mario Mitt et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities
- (2017) Venexia M Walker et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Triangulation in aetiological epidemiology
- (2017) Debbie A. Lawlor et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia
- (2017) Lothar Seefried et al. JOURNAL OF CLINICAL INVESTIGATION
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
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- (2017) John P Kemp et al. NATURE GENETICS
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- (2017) Christopher P Nelson et al. NATURE GENETICS
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- (2017) Clifford J. Rosen NEW ENGLAND JOURNAL OF MEDICINE
- Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis
- (2017) Kenneth G. Saag et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes
- (2017) Soohyun P. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contribution of industry funded post-marketing studies to drug safety: survey of notifications submitted to regulatory agencies
- (2017) Angela Spelsberg et al. BMJ-British Medical Journal
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- (2017) Eleanor Wheeler et al. PLOS MEDICINE
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- (2017) Sundeep Khosla et al. Lancet Diabetes & Endocrinology
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- (2016) Smriti Murali Krishna et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2016) Guido Kranenburg et al. ATHEROSCLEROSIS
- Analysis of protein-coding genetic variation in 60,706 humans
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- (2016) Felicia Cosman et al. NEW ENGLAND JOURNAL OF MEDICINE
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- Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
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- (2015) Daniel I Swerdlow et al. LANCET
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- (2015) Dmitry Shungin et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
- (2015) Hou‐Feng Zheng et al. NATURE
- A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
- (2015) Majid Nikpay et al. NATURE GENETICS
- Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
- (2015) Louise V Wain et al. Lancet Respiratory Medicine
- Feature Selection with theBorutaPackage
- (2015) Miron B. Kursa et al. Journal of Statistical Software
- Bisphosphonates and Risk of Cardiovascular Events: A Meta-Analysis
- (2015) Dae Hyun Kim et al. PLoS One
- Romosozumab in Postmenopausal Women with Osteopenia
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Romosozumab in Postmenopausal Women with Low Bone Mineral Density
- (2014) Michael R. McClung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
- (2014) P. Pound et al. BMJ-British Medical Journal
- Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
- (2014) Claudia Giambartolomei et al. PLoS Genetics
- Genetics of coronary artery calcification among African Americans, a meta-analysis
- (2013) Mary K Wojczynski et al. BMC Medical Genetics
- RANKL Inhibition With Denosumab Does Not Influence 3-Year Progression of Aortic Calcification or Incidence of Adverse Cardiovascular Events in Postmenopausal Women With Osteoporosis and High Cardiovascular Risk
- (2013) Elizabeth J Samelson et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Sclerostin: Another Vascular Calcification Inhibitor?
- (2013) Kathleen J. Claes et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Secretory Phospholipase A 2 -IIA and Cardiovascular Disease
- (2013) Michael V. Holmes et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study
- (2013) Vincent M Brandenburg et al. BMC Nephrology
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- (2012) Alisa K Manning et al. NATURE GENETICS
- Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
- (2012) Jian Yang et al. NATURE GENETICS
- Coexistence of osteoporosis (OP) and coronary artery disease (CAD) in the elderly: It is not just a by chance event
- (2011) Yusuf Yesil et al. ARCHIVES OF GERONTOLOGY AND GERIATRICS
- The Regulation of Valvular and Vascular Sclerosis by Osteogenic Morphogens
- (2011) Kristina I. Boström et al. CIRCULATION RESEARCH
- China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up
- (2011) Z. Chen et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- Serum sclerostin levels positively correlate with lumbar spinal bone mineral density in postmenopausal women—the six-month effect of risedronate and teriparatide
- (2011) S. A. Polyzos et al. OSTEOPOROSIS INTERNATIONAL
- The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells
- (2011) Dongxing Zhu et al. PLoS One
- Robust relationship inference in genome-wide association studies
- (2010) Ani Manichaikul et al. BIOINFORMATICS
- Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia
- (2009) Anne Saarinen et al. CLINICAL ENDOCRINOLOGY
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