Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K/AKT/AS160 pathway

Highly bioavailable berberine formulation ameliorates diabetic nephropathy through the inhibition of glomerular mesangial matrix expansion and the activation of autophagy

(2020) Meishuang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Low molecular weight fucoidan alleviates diabetic nephropathy by binding fibronectin and inhibiting ECM-receptor interaction in human renal mesangial cells

(2020) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

FGF1ΔHBS ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation

(2019) Dezhong Wang et al.   Cell Death & Disease

Paeoniflorin Inhibits Mesangial Cell Proliferation and Inflammatory Response in Rats With Mesangial Proliferative Glomerulonephritis Through PI3K/AKT/GSK-3β Pathway

(2019) Bihao Liu et al.   Frontiers in Pharmacology

The Influence of a Nanopatterned Scaffold that Mimics Abnormal Renal Mesangial Matrix on Mesangial Cell Behavior

(2019) Chia-Jung Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zhen-wu-tang protects against podocyte injury in rats with IgA nephropathy via PPARγ/NF-κB pathway

(2018) Bihao Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

SOCS1-targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and PI3K inhibition

(2018) Laura Lopez-Sanz et al.   LABORATORY INVESTIGATION

Astragaloside IV inhibits TGF-β1-induced epithelial-mesenchymal transition through inhibition of the PI3K/Akt/NF-κB pathway in gastric cancer cells

(2018) Jihong Zhu et al.   PHYTOTHERAPY RESEARCH

Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro

(2017) Xiangjun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Determination of the optimal target level of proteinuria in the management of patients with glomerular diseases by using different definitions of proteinuria

(2017) Youn Kyung Kee et al.   MEDICINE

Niclosamide attenuates inflammatory cytokines via the autophagy pathway leading to improved outcomes in renal ischemia/reperfusion injury

(2017) Lin-Xia Zhang et al.   Molecular Medicine Reports

Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

(2017) Isamu Murata et al.   Annals of Intensive Care

Cell biology of mesangial cells: the third cell that maintains the glomerular capillary

(2016) Hidetake Kurihara et al.   ANATOMICAL SCIENCE INTERNATIONAL

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis

(2016) Xue Zhao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Zhen-wu-tang attenuates cationic bovine serum albumin-induced inflammatory response in membranous glomerulonephritis rat through inhibiting AGEs/RAGE/NF-κB pathway activation

(2016) Junbiao Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Coordination of autophagosome–lysosome fusion and transport by a Klp98A–Rab14 complex inDrosophila

(2016) Caroline Mauvezin et al.   JOURNAL OF CELL SCIENCE

Primary glomerulonephritides

(2016) Jürgen Floege et al.   LANCET

Role of PI3K/Akt signal pathway on proliferation of mesangial cell induced by HMGB1

(2016) Xiaojuan Feng et al.   TISSUE & CELL

Astragaloside IV ameliorates renal injury in db/db mice

(2016) Huili Sun et al.   Scientific Reports

The Future Burden of CKD in the United States: A Simulation Model for the CDC CKD Initiative

(2015) Thomas J. Hoerger et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-β1/Smad Signaling Pathway

(2015) Yingjie Cao et al.   Evidence-based Complementary and Alternative Medicine

Protective effect of astragaloside IV on lipopolysaccharide-induced cardiac dysfunction via downregulation of inflammatory signaling in mice

(2015) Peng Zhao et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Cellular functions of Rab GTPases at a glance

(2015) Y. Zhen et al.   JOURNAL OF CELL SCIENCE

 Klotho Mitigates Progression of AKI to CKD through Activation of Autophagy

(2015) M. Shi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress

(2015) Zeng Si Wang et al.   BMC Nephrology

Oxidative stress and autophagy: Crucial modulators of kidney injury

(2015) Angara Sureshbabu et al.   Redox Biology

Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage

(2014) Chun-ling Liang et al.   Evidence-based Complementary and Alternative Medicine

Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF-κB pathway under high glucose conditions

(2014) LI SUN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Efficacy and Safety of Traditional Chinese Medicine (Shenqi Particle) for Patients With Idiopathic Membranous Nephropathy: A Multicenter Randomized Controlled Clinical Trial

(2013) Yiping Chen et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases

(2013) Stephanie Schwalm et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases

(2013) Yifei Zhong et al.   KIDNEY INTERNATIONAL

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Aldose reductase regulates platelet-derived growth factor-induced proliferation through mediating cell cycle progression in rat mesangial cells

(2012) LIPING ZOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Phosphatidylinositol 3-kinases and their roles in phagosome maturation

(2012) E. P. Thi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proteinuria and progression of glomerular diseases

(2012) Elif Erkan   PEDIATRIC NEPHROLOGY

Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy

(2010) Mingxin Li et al.   JOURNAL OF ETHNOPHARMACOLOGY