Review
Immunology
Zoya Qaiyum, Melissa Lim, Robert D. Inman
Summary: The genetic and clinical similarities between spondyloarthritis (SpA) and inflammatory bowel disease (IBD) have led to a focus on the gut-joint axis of inflammation, resulting in three key hypotheses attempting to unravel this complex relationship. These hypotheses explore the interactions between the immune system, microbiome, and joint inflammation in SpA, providing insights for potential novel therapeutic targets and implications for predicting the likelihood of IBD development in SpA patients or the presence of coincident SpA-IBD.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Zengliang Jiang, Lai-bao Zhuo, Yan He, Yuanqing Fu, Luqi Shen, Fengzhe Xu, Wanglong Gou, Zelei Miao, Menglei Shuai, Yuhui Liang, Congmei Xiao, Xinxiu Liang, Yunyi Tian, Jiali Wang, Jun Tang, Kui Deng, Hongwei Zhou, Yu-ming Chen, Ju-Sheng Zheng
Summary: Evidence from human cohorts suggests that chronic insomnia is associated with a higher risk of cardiometabolic diseases. The gut microbiota-bile acid axis may play a role in this association. Certain gut microbial biomarkers and bile acids mediate the positive association between chronic insomnia and CMD, while habitual tea consumption has an opposite effect. Interventions targeting the microbiota-bile acid axis could potentially reduce the impact of chronic insomnia on cardiometabolic health.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ding Yang, Zixu Wang, Yaoxing Chen, Qingyun Guo, Yulan Dong
Summary: The role of the gut-brain axis in maintaining homeostasis of the brain and gut has been recognized. The NLRP3 inflammasome plays a crucial role in coordinating host physiology and immunity. More research is needed to determine the causal link between gut microbiota structure and NLRP3 activation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Rheumatology
Mario M. Zaiss, Hsin-Jung Joyce Wu, Daniele Mauro, Georg Schett, Francesco Ciccia
Summary: The review discusses the role of intestinal dysbiosis in rheumatoid arthritis and highlights the potential pathogenic role of gut-derived immune cells in the joints. It also explores the hypothesis that alterations in the microbial flora may precede the onset of RA and suggests that modulation of intestinal microbiota could be a potential therapeutic approach for preventing or treating RA.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Immunology
Daniele Mauro, Akihiro Nakamura, Nigil Haroon, Francesco Ciccia
Summary: Subclinical inflammation is linked to Spondylarthritis (SpA), with patients exhibiting dysbiosis, altered gut barrier function, and expansion of certain immune cells. Research suggests that activated intestinal immune cells may circulate in the blood and affect joints, supporting the gut-joint axis theory, and a potential gut-enthesis axis may also play a role in SpA development.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Isabelle McKay, Josie van Dorst, Tamarah Katz, Michael Doumit, Bernadette Prentice, Louisa Owens, Yvonne Belessis, Sandra Chuang, Adam Jaffe, Torsten Thomas, Michael Coffey, Chee Y. Ooi
Summary: This study conducted a comprehensive analysis of diet and microbiota in children with CF, finding significant changes in intestinal inflammation and respiratory and gastrointestinal microbiota compared to children without CF. It also identified correlations between gastrointestinal and respiratory microbiota, lung function, CF pulmonary exacerbations, and anthropometrics, supporting the concept of an altered gut-lung axis in children with CF. Additionally, significant differences in dietary quality were found, with CF children consuming higher proportions of fats and lower proportions of carbohydrates, wholegrains, fiber, insoluble fiber, starch, and resistant starch.
Review
Microbiology
Tadatsugu Morimoto, Takaomi Kobayashi, Toshihiko Kakiuchi, Motohiro Esaki, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Shoji Yabuki, Masaaki Mawatari
Summary: As society ages, the increasing number of patients with spinal degenerative diseases (SDD) poses a major socioeconomic problem. This review proposes the concept of the gut-spine axis, which examines the influence of gut microbiota (GM) on the metabolic, immune, and endocrine environment of hosts. By summarizing the evidence linking GM abnormalities to SDD, this article provides novel insights into the pathogenesis and treatment of SDD.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Xiaoyu Xu, Miao Wang, Zikang Wang, Qian Chen, Xixuan Chen, Yingyue Xu, Min Dai, Bin Wu, Yanping Li
Summary: Gut microbiota dysbiosis may exacerbate rheumatoid arthritis (RA) through the gut-joint axis, but the specific regulatory mechanisms are still unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Pinky Juneja, Dinesh M. Tripathi, Savneet Kaur
Summary: The gut lymphatic system plays a significant role in maintaining gut health, but it is one of the least studied physiological systems. The gut-liver axis is crucial in the pathogenesis of liver diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Angel Yun-Kuan Thye, Yi-Rou Bah, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Ya-Wen He, Sunny-Hei Wong, Sivakumar Thurairajasingam, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan
Summary: Evidence suggests that the gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health, regulated through mechanisms such as inflammatory mediators and the immune system. Microbiota dysregulation has been observed in various inflammatory skin conditions, such as atopic dermatitis, rosacea, and psoriasis. Understanding the involvement of the gut microbiome in regulating skin health could lead to the development of novel therapies for these skin disorders, particularly psoriasis.
Review
Medicine, Research & Experimental
Emeran A. Mayer, Karina Nance, Shelley Chen
Summary: Preclinical evidence has shown bidirectional interactions among the brain, gut, and gut microbiome, with candidate signaling molecules and three communication channels. Alterations in gut-brain-microbiome interactions have been found in various disorders, but the causative role of the microbiome in irritable bowel syndrome is still unclear. Current therapies are limited to dietary interventions and targeted pharmacological and behavioral approaches. Further research and randomized controlled trials are needed for effective therapies.
ANNUAL REVIEW OF MEDICINE
(2022)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaolin Liu, Nina van Beek, Aleksa Cepic, Nadia A. Andreani, Cecilia J. Chung, Britt M. Hermes, Kaan Yilmaz, Sandrine Benoit, Kossara Drenovska, Sascha Gerdes, Regine Glaeser, Matthias Goebeler, Claudia Guenther, Anabelle von Georg, Christoph M. Hammers, Maike M. Holtsche, Franziska Huebner, Dimitra Kiritsi, Franziska Schauer, Beke Linnenmann, Laura Huilaja, Kaisa Tasanen-Maatta, Snejina Vassileva, Detlef Zillikens, Christian D. Sadik, Enno Schmidt, Saleh Ibrahim, John F. Baines
Summary: Bullous pemphigoid patients have altered gut microbiota composition and function, with decreased microbial diversity and overall changed microbial community. Disease-associated gut microbial features, including reduced Faecalibacterium prausnitzii and increased pathways related to gamma-aminobutyric acid metabolism, are observed in BP patients. These findings suggest that gut microbiota alterations may play a role in the development of bullous pemphigoid.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Hai-long Yang, Meng-Meng Li, Man-Fei Zhou, Huai-Sha Xu, Fei Huan, Na Liu, Rong Gao, Jun Wang, Ning Zhang, Lei Jiang
Summary: This study investigated the mechanisms of depression induced by chronic restraint stress from the perspectives of inflammation, gut microbiota, and neurotransmitters. It was found that CRS led to inflammatory reactions, disturbances in neurotransmitter metabolism, and dysbiosis in gut microbiota. The study suggests potential links between microbiota dysbiosis and neurotransmitter metabolism in CRS-induced depression, providing new strategies for depression treatment.
Article
Thermodynamics
Rana Muhammad Adeel-Farooq, Muhammad Faraz Riaz, Tariq Ali
Summary: This article examines the impact of foreign direct investment (FDI) from developed and developing countries on the environmental quality of 76 countries over a 10-year period. The results show that FDI from developed countries improves environmental performance in host countries, while FDI from developing countries has a negative impact. This highlights the importance of policies in the source country in determining the environmental effects of FDI.
Editorial Material
Gastroenterology & Hepatology
Yoichi Kakuta, Tsuyoshi Shirai, Dermot P. B. Mcgovern, Jonathan Braun, Hiroshi Fujii, Atsushi Masamune
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nghia H. Nguyen, Jiyu Luo, Paulina Paul, Jihoon Kim, Gaurav Syal, Christina Ha, Vivek Rudrapatna, Sunhee Park, Nimisha Parekh, Kai Zheng, Jenny S. Sauk, Berkeley Limketkai, Phillip Fleshner, Samuel Eisenstein, Sonia Ramamoorthy, Gil Melmed, Parambir S. Dulai, Brigid S. Boland, Uma Mahadevan, William J. Sandborn, Lucila Ohno-Machado, Dermot McGovern, Siddharth Singh
Summary: Hispanic patients with IBD who are treated with biologic therapy have a higher risk of hospitalization, surgery, and serious infections compared to non-Hispanic patients. Further research is needed to investigate the biological, social, and environmental factors underlying these differences.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Phillip Gu, Shishir Dube, Dermot P. B. McGovern
Summary: Alterations in mesenteric adipose tissue play a significant role in Crohn's disease, but their clinical significance is still unclear. Current studies have limitations, but they suggest that mesenteric adipose tissue may serve as a marker for disease severity, surgical risk, and postoperative outcomes. Additionally, it could be a potential target for mitigating postoperative recurrence of Crohn's disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Julia J. Liu, Bincy P. Abraham, Paula Adamson, Edward L. Barnes, Kelly A. Brister, Oriana M. Damas, Sarah C. Glover, Kimberly Hooks, Ana Ingram, Gilaad G. Kaplan, Edward V. Loftus, Dermot P. B. McGovern, Melodie Narain-Blackwell, Florence-Damilola Odufalu, Sandra Quezada, Vonda Reeves, Bo Shen, Thaddeus S. Stappenbeck, Latonia Ward
Summary: This comprehensive review examines the epidemiology, clinical presentations, disease phenotypes, treatment outcomes, social determinants of health, and genetic and environmental factors in the pathogenesis of IBD in Black and Hispanic patients in the United States. To improve health equity for underserved minorities with IBD, researchers identified priority areas for further investigation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Andres J. Yarur, Dermot McGovern, Maria T. Abreu, Adam Cheifetz, Konstantinos Papamichail, Parakkal Deepak, Alexandra Bruss, Poonam Beniwal-Patel, Marla Dubinsky, Stephan R. Targan, Gil Y. Melmed
Summary: This study assessed the relationship between 6-thioguanine nucleotide (6-TGN) levels and the use of oral methotrexate with the pharmacokinetics of biologics. The results showed that higher 6-TGN levels and the use of methotrexate improved the pharmacokinetics of infliximab but did not have the same effect on vedolizumab and ustekinumab. These findings have important implications for clinical treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Roberto Y. Cordero, Jennifer B. Cordero, Andrew B. Stiemke, Lisa W. Datta, Steven Buyske, Subra Kugathasan, Dermot P. B. McGovern, Steven R. Brant, Claire L. Simpson
Summary: This study is the first attempt to identify loci related to inflammatory bowel disease in African Americans using a trans-ancestry Bayesian approach. The study discovered several novel loci containing immunity-related genes or genes with other evidence for IBD or immune-mediated disease relevance. The findings highlight the importance of studying diverse ancestral populations to enable the discovery of new loci and potential therapeutic targets for IBD.
HUMAN MOLECULAR GENETICS
(2023)
Article
Endocrinology & Metabolism
Chaobo Lai, Jennifer Heinemann, Ulrike Schleicher, Georg Schett, Christian Bogdan, Aline Bozec, Didier Soulat
Summary: Chronic infection with Leishmania increases bone mass by inducing bone formation and impairing osteoclast differentiation and function.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Rheumatology
Merlijn H. Kaaij, Jan Piet van Hamburg, Charlotte C. N. van Rooijen, Anika Grueneboom, Yik Y. Kan, Desiree Pots, Georg Schett, Leo J. van Ruijven, Leonie M. van Duivenvoorde, Leonie F. A. Huitema, Dominique L. P. Baeten, Sander W. Tas
Summary: This study found that the increase of type H vessels in a transgenic mouse model is closely related to pathologic osteogenesis. This finding provides new insights into the pathophysiology of ankylosing spondylitis and may offer a novel target for intervention.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Larissa Valor-Mendez, Armin Atzinger, Petra Reis, Bernhard Manger, Georg Schett
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anton De Spiegeleer, Amelie Descamps, Srinath Govindarajan, Julie Coudenys, Kevin van der Borght, Hannah Hirmz, Nele van den Noortgate, Dirk Elewaut, Bart De Spiegeleer, Evelien Wynendaele
Summary: This study discovered the potential of quorum-sensing peptides to modulate the immune system in microbiome-host interactions. Through screening 89 peptides, four of them were found to activate immune cells in vitro, and one of them was detected in human plasma. These findings are biologically significant and reveal the immunomodulatory potential of quorum-sensing peptides.
Article
Rheumatology
David Simon, Ioanna Minopoulou, Stephan Kemenes, Sara Bayat, Koray Tascilar, Melek Yalcin Mutlu, Larissa Valor-Mendez, Gerhard Kroenke, Axel J. Hueber, Georg Schett, Arnd Kleyer
Summary: Objective. This study aimed to evaluate the effect of Janus kinase inhibition (JAKi) through baricitinib (BARI) on bone properties and synovial inflammation in rheumatoid arthritis (RA) patients. Results showed that BARI therapy significantly improved disease activity, synovial inflammation, and bone mass of RA patients, with no new safety signals observed.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Xiang Zhou, Thuong Trinh-Minh, Alexandru-Emil Matei, Andrea-Hermina Gyoerfi, Xuezhi Hong, Christina Bergmann, Georg Schett, John Atkinson, Rowann Bowcutt, Jessal Patel, Timothy S. Johnson, Joerg H. W. Distler
Summary: In this study, increased expression and activity of TG2 were observed in systemic sclerosis (SSc) patients. Inhibition of TG2 in dermal fibroblasts resulted in reduced fibrosis, suggesting that targeting TG2 may be a potential antifibrotic approach in SSc.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Daniele Mauro, Saviana Gandolfo, Enrico Tirri, Georg Schett, Walter P. P. Maksymowych, Francesco Ciccia
Summary: This perspective discusses the evidence that supports a bone marrow origin for spondyloarthritis, rather than an entheseal origin. Focusing on immune cells and dysfunction in the bone marrow niche could alter the therapeutic approach to spondyloarthritis.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Cell Biology
Lien Verboom, Christopher J. J. Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S. S. Ravichandran, Lars Vereecke, Geert van Loo
Summary: The deficiency of OTULIN protein in intestinal epithelial cells leads to excessive apoptosis and increased susceptibility to colitis and inflammation in the intestine. This deficiency also promotes gastrointestinal inflammation and susceptibility to Salmonella infection.
CELL DEATH & DISEASE
(2023)
Article
Microbiology
Alexandra L. Degraeve, Vincent Haufroid, Axelle Loriot, Laurent Gatto, Vanessa Andries, Lars Vereecke, Laure Elens, Laure B. Bindels
Summary: This study found that oral administration of tacrolimus (TAC) can alter the composition of the gut microbiota, and the gut microbiota can affect TAC pharmacokinetics (PK). The study also revealed that bacterial metabolites regulate the expression of ABCB1, which in turn affects TAC PK. This research is clinically important for understanding the variability of TAC PK and incorporating the gut microbiota into drug dosage prediction algorithms.