Review
Immunology
Charlie Bridgewood, Darren Newton, Nicola Bragazzi, Miriam Wittmann, Dennis McGonagle
Summary: The IL-23/IL-17 cytokine axis is associated with spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints, sharing some common characteristics with Th2 type or allergic diseases but also exhibiting distinct features. These findings suggest a dynamic Th2 and Th17 cytokine counter regulation in vivo in humans.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Immunology
Zoya Qaiyum, Melissa Lim, Robert D. Inman
Summary: The genetic and clinical similarities between spondyloarthritis (SpA) and inflammatory bowel disease (IBD) have led to a focus on the gut-joint axis of inflammation, resulting in three key hypotheses attempting to unravel this complex relationship. These hypotheses explore the interactions between the immune system, microbiome, and joint inflammation in SpA, providing insights for potential novel therapeutic targets and implications for predicting the likelihood of IBD development in SpA patients or the presence of coincident SpA-IBD.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Helena Marcos Pasero, Aurora Garcia Tejedor, Juan Antonio Gimenez-Bastida, Jose Moises Laparra Llopis
Summary: Alzheimer's disease is a inflammation-related cognitive decline, with the immune microenvironment playing a crucial role in its pathogenesis. Various peripheral stimuli are involved in the progression and severity of the disease. Targeting immune signals and cells is achievable, but more understanding of their contribution to the disease is needed for effective interventions. An integrative perspective can improve the health of AD patients.
Article
Chemistry, Medicinal
Weina Zhu, Chunhua Ma, Jie Ruan, Fuqiong Zhou, Yajie Zhang, Hongyan Long
Summary: This study demonstrates that sinomenine (SIN) can activate the innate immune function of the intestinal tract by suppressing the IL-23/IL-17 axis through the AhR pathway.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Neurosciences
Yang Jiang, Yajie Dai, Zhenquan Liu, Yan Liao, Shuyong Sun, Xianghe Kong, Jingjing Hu, Yibo Tang
Summary: Bidirectional communication between the central nervous system (CNS) and intestine is mediated by various pathways in the gut-brain axis. Disturbance in the homeostasis of intestine and gut microbiota can lead to CNS diseases, while dysbiosis of intestinal and gut microbiota can worsen the progression of CNS diseases. The IL-23/IL-17 axis has been found to play an important role in CNS diseases such as experimental autoimmune encephalomyelitis (EAE), multiple sclerosis (MS), and ischemic stroke (IS). This review focuses on the relationship between the IL-23/IL-17 axis and IS from the perspective of the gut-brain axis, aiming to provide insights for the treatment strategies of IS.
Review
Rheumatology
Mario M. Zaiss, Hsin-Jung Joyce Wu, Daniele Mauro, Georg Schett, Francesco Ciccia
Summary: The review discusses the role of intestinal dysbiosis in rheumatoid arthritis and highlights the potential pathogenic role of gut-derived immune cells in the joints. It also explores the hypothesis that alterations in the microbial flora may precede the onset of RA and suggests that modulation of intestinal microbiota could be a potential therapeutic approach for preventing or treating RA.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Allergy
Stuart G. Tangye, Anne Puel
Summary: Chronic mucocutaneous candidiasis (CMC) is recognized as a primary immunodeficiency, and recent studies have identified the genetic etiology of CMC linked to impaired IL-17-mediated immunity. The IL-17 axis plays a crucial role in mucocutaneous immunity to Candida spp and Staphylococcus aureus in humans, while it seems to be redundant against other common microbes. This review provides an overview of the current understanding of IL-17A/F-mediated immunity and its relevance in human immunity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Article
Agriculture, Dairy & Animal Science
Yuechi Fu, Jiaying Hu, Heng-wei Cheng
Summary: High ambient temperature can cause gut microbiota dysbiosis and increase gut permeability, resulting in neuroinflammation in various animals. This study found that dietary supplementation of the probiotic Bacillus subtilis reduced neuroinflammation in heat-stressed broiler chickens by decreasing the levels of inflammatory markers in the hippocampus. These results suggest the potential use of probiotics as a management strategy for reducing the impact of heat stress on poultry production.
Article
Microbiology
Carlos Henrique D. Barbosa, Louis Lantier, Joseph Reynolds, Jinyong Wang, Fabio Re
Summary: Immunization with Ft LPS triggers production of IL-25, which promotes activation and differentiation of B1 cells into IgM secreting cells through stimulation of IL-5 release by ILC2. This IL-25-ILC2-IL-5 axis represents a potential novel strategy to improve vaccination against T-independent bacterial antigens.
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Multidisciplinary Sciences
Gulistan Agirman, Kristie B. Yu, Elaine Y. Hsiao
Summary: The brain and gastrointestinal tract, as critical sensory organs, interact through immune cells along the gut-brain axis to regulate inflammatory responses and immune balance, affecting the physiological state of the body.
Article
Respiratory System
Tae-Ok Kim, Ki-Jeong Park, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hyo Shin Kim, Jae Kyun Ju, Hong-Joon Shin, Bo-Gun Kho, Seung-Jung Kee, Yong-Wook Park
Summary: The study demonstrates that circulating MAIT cells are numerically deficient in patients with ARDS. These MAIT cells are activated, migrate into the lung, secrete IL-17, and stimulate macrophages, contributing to the worsening of inflammation in the lung of patients with ARDS.
Review
Biochemistry & Molecular Biology
Noria Segueni, Muazzam Jacobs, Bernhard Ryffel
Summary: Studies on the innate immune response to Mycobacterium tuberculosis infection suggest that the IL-17 and IL-22 pathways play a limited role in infection control, and neutralizing IL-17 does not affect infection control.
BIOMEDICAL JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ali Tugrul Gur, Guliz N. Guncu, Abdullah C. Akman, Asli Pinar, Erdem Karabulut, Rahime M. Nohutcu
Summary: The aim of this study was to evaluate the clinical efficacy of diode laser as an adjunct to SRP and determine the biochemical profile in GCF. The results showed that the diode laser group had significant differences in some clinical and biochemical parameters after treatment.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Rheumatology
Giuliana Guggino, Daniele Mauro, Aroldo Rizzo, Riccardo Alessandro, Stefania Raimondo, Anne-Sophie Bergot, M. Arifur Rahman, Jonathan J. Ellis, Simon Milling, Rik Lories, Dirk Elewaut, Matthew A. Brown, Ranjeny Thomas, Francesco Ciccia
Summary: The study showed that inflammasome activation occurs in rodent models of AS and in AS patients, is associated with dysbiosis, and is involved in triggering ileitis in SKG mice. Inflammasomes drive type III cytokine production with an IL-1 beta-dependent mechanism in AS patients.
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Rheumatology
Mario M. Zaiss, Hsin-Jung Joyce Wu, Daniele Mauro, Georg Schett, Francesco Ciccia
Summary: The review discusses the role of intestinal dysbiosis in rheumatoid arthritis and highlights the potential pathogenic role of gut-derived immune cells in the joints. It also explores the hypothesis that alterations in the microbial flora may precede the onset of RA and suggests that modulation of intestinal microbiota could be a potential therapeutic approach for preventing or treating RA.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Immunology
Daniele Mauro, Davide Simone, Laura Bucci, Francesco Ciccia
Summary: Spondyloarthritis (SpA) is a group of chronic inflammatory diseases with unknown causes. Recent research suggests the involvement of new cellular mediators in the pathogenesis, potentially leading to new targeted therapies for controlling inflammation.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Rheumatology
Ilenia Pantano, Daniele Mauro, Francesca Romano, Alessio Gambardella, Mario Valenti, Davide Simone, Daniela Iacono, Antonio Costanzo, Giuseppe Argenziano, Francesco Ciccia
Summary: This observational study aimed to assess the efficacy of the novel anti-IL-23 monoclonal antibody guselkumab in early PsA patients. The results demonstrated that guselkumab was effective and safe in treating both peripheral and axial manifestations of early PsA in a real-life setting.
Article
Medicine, General & Internal
Francesco Salvatore Iaquinta, Rosa Daniela Grembiale, Daniele Mauro, Ilenia Pantano, Saverio Naty, Cristina Cosco, Daniela Iacono, Emanuela Gaggiano, Annarita Ruggiero, Francesco Ciccia, Patrizia Doldo, Rocco Spagnuolo
Summary: This study assessed the prevalence of fatigue and its associated factors in patients with immune-mediated inflammatory diseases (IMIDs). The results showed that anxiety and depression were the main factors associated with fatigue, suggesting a psychological component of the symptom. This highlights the need for a comprehensive management approach.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Rocco Spagnuolo, Francesco Salvatore Iaquinta, Daniele Mauro, Ilenia Pantano, Stefano Dastoli, Saverio Naty, Cristina Cosco, Rosellina Margherita Mancina, Daniela Iacono, Emanuela Gaggiano, Annarita Ruggiero, Steven Paul Nistico, Francesco Ciccia, Rosa Daniela Grembiale, Doldo Patrizia
Summary: This study aimed to assess satisfaction with social roles and physical function alterations in patients with immune-mediated inflammatory diseases and identify associated characteristics. The results showed that these diseases have a negative impact on physical function and satisfaction with social roles. Gender and treatment were found to be independently associated factors.
REVIEWS ON RECENT CLINICAL TRIALS
(2022)
Article
Immunology
Daniele Mauro, Antonio Ciancio, Claudio Di Vico, Luana Passariello, Gelsomina Rozza, Maria Dora Pasquale, Ilenia Pantano, Carlo Cannistra, Laura Bucci, Silvia Scriffignano, Flavia Riccio, Martina Patrone, Giuseppe Scalise, Piero Ruscitti, Maria Vittoria Montemurro, Antonio Giordano, Maria Teresa Vietri, Francesco Ciccia
Summary: This study aims to identify factors associated with non-response to anti-SARS-CoV-2 vaccines in patients with immune rheumatic diseases (IRD) and immunosuppressive medications. The study found that IRD patients had a lower seroconversion rate and lower antibody titer compared to controls, indicating a poor response to the vaccines. Age and the use of corticosteroids, Abatacept, and Mycophenolate Mofetil were associated with non-response. Specific vaccination protocols are needed for IRD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Daniele Mauro, Archita Srinath, Giuliana Guggino, Vicky Nicolaidou, Stefania Raimondo, Jonathan J. Ellis, Jessica Whyte, Maria Maddalena Nicoletti, Marco Romano, Tony John Kenna, Juan D. Canete, Riccardo Alessandro, Aroldo Rizzo, Matthew Arthur Brown, Nicole J. Horwood, Nigil Haroon, Francesco Ciccia
Summary: Ankylosing spondylitis (AS) is an inflammatory disease that leads to spine ankylosis. The mechanisms of new bone formation in AS are not fully understood, but Single Nucleotide Polymorphisms (SNPs) in the PTGER4 gene have been associated with AS. This study found that the PGE2-EP4 axis, which is involved in inflammation and bone metabolism, may contribute to radiographic progression in AS. Baseline serum PGE2 levels and the PTGER4 SNP rs6896969 were found to predict progression in AS patients. Increased expression of EP4/PTGER4 was observed in immune cells, synovial tissue, and bone marrow of AS patients. The PGE2/EP4 axis also induced bone formation when monocytes were cocultured with mesenchymal stem cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Daniele Mauro, Sotiria Manou-Stathopoulou, Felice Rivellese, Elisabetta Sciacca, Katriona Goldmann, Victoria Tsang, Isabelle Lucey-Clayton, Sara Pagani, Farah Alam, Debasish Pyne, Ravindra Rajakariar, Patrick A. Gordon, James Whiteford, Michele Bombardieri, Costantino Pitzalis, Myles J. Lewis
Summary: Study finds that UBE2L3 plays a critical role in TLR7-mediated NF-??B activation in Systemic Lupus Erythematosus (SLE). Inhibition of UBE2L3 by Dimethyl Fumarate (DMF) can effectively suppress TLR7-induced NF-??B activation, B cell differentiation, and autoantibody production in SLE. This suggests that UBE2L3 inhibition could be a potential therapeutic strategy for SLE by repurposing DMF.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Medicine, General & Internal
Francesco Salvatore Iaquinta, Daniele Mauro, Ilenia Pantano, Saverio Naty, Daniela Iacono, Emanuela Gaggiano, Luca Riccio, Francesco Ciccia, Rosa Daniela Grembiale, Rocco Spagnuolo
Summary: Patients with chronic Inflammatory Arthritis (IA), such as Rheumatoid Arthritis (RA) and Spondyloarthritis (SpA), experience higher psychosocial and gastrointestinal impairment. This study aimed to assess these symptoms in an IA population and identify potential associations. The findings suggest the need for a holistic approach to address reported symptoms and improve the overall quality of life in rheumatologic patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Luigi Napolitano, Ilenia Pantano, Lorenzo Romano, Luigi Cirillo, Celeste Manfredi, Francesco Mastrangelo, Giovanni Maria Fusco, Daniele Mauro, Lorenzo Spirito, Roberto La Rocca, Davide Arcaniolo, Corrado Aniello Franzese, Carmine Sciorio, Marco Romano, Marco De Sio, Vincenzo Mirone, Francesco Ciccia
Summary: This study assessed the attention, knowledge, and barriers to discussing sexual dysfunction (SD) in patients with rheumatologic diseases among members of the Italian Society of Rheumatology. The results showed that only half of the respondents occasionally asked patients about SD related to their rheumatologic pathologies, and a significant percentage never did so. The main barriers to discussing sexual health were lack of time, patient discomfort, and lack of knowledge/experience. However, most respondents expressed the potential usefulness of attending SD courses to improve knowledge about these conditions.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Rheumatology
Ilenia Di Cola, Daniela Iacono, Ilenia Pantano, Daniele Mauro, Antonio Vitale, Francesco Caso, Ludovico De Stefano, Marcella Prete, Luca Navarini, Jacopo Ciaffi, Francesco Ursini, Luisa Costa, Federico Perosa, Carlomaurizio Montecucco, Luca Cantarini, Bruno Frediani, Francesco Ciccia, Roberto Giacomelli, Paola Cipriani, Piero Ruscitti
Summary: This study evaluated the impact of obesity on patients with adult-onset Still's disease (AOSD) and assessed their clinical characteristics and disease outcomes. The results showed that obese patients had a lower prevalence of sore throat, serositis, higher levels of CRP and ferritin, higher rate of bDMARD failure, and a higher rate of comorbidity. Obesity was also found to be a predictive factor for a chronic disease course and bDMARD failure in AOSD patients.
Review
Rheumatology
L. De Stefano, B. D'Onofrio, S. Gandolfo, E. Bozzalla Cassione, D. Mauro, A. Manzo, F. Ciccia, S. Bugatti
Summary: In the past 20 years, earlier diagnosis and more intensive management have significantly improved the prognosis of rheumatoid arthritis, particularly in seropositive patients. However, seronegative rheumatoid arthritis remains surrounded by uncertainties, including its correct diagnosis, clinical phenotype, optimal treatment strategies, and relevant outcomes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
P. R. Sternes, L. Brett, J. Phipps, F. Ciccia, T. Kenna, E. de Guzman, K. Zimmermann, M. Morrison, G. Holtmann, E. Klingberg, D. Mauro, C. McIvor, H. Forsblad-d'Elia, M. A. Brown
Summary: The gut microbiomes of AS and AS-IBD patients are different from IBD patients and healthy controls, indicating a distinct role of the gut in driving AS compared with IBD. However, the presence of potentially pathogenic genera shared between both diseases suggests a common microbial trigger of disease.
ARTHRITIS RESEARCH & THERAPY
(2022)
Letter
Rheumatology
S. Criffignano, M. Auro, R. . Aimondi, C. Iccia, R. Tirri
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
