Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1

Antibiotics-induced depletion of rat microbiota induces changes in the expression of host drug-processing genes and pharmacokinetic behaviors of CYPs probe drugs

(2023) Haijun Yang et al.   DRUG METABOLISM AND DISPOSITION

OPTN/SRTR 2020 Annual Data Report: Kidney

(2022) K. L. Lentine et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Rethinking healthy eating in light of the gut microbiome

(2022) Anissa M. Armet et al.   Cell Host & Microbe

Bacillus subtilis plays a role in the inhibition of transporter ABCB1 in Caco-2 cells

(2022) Yuanyuan Dai et al.   EPILEPSY RESEARCH

Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

(2022) Sage E. Foley et al.   mBio

Multi‐compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice

(2021) Sarah A. Pötgens et al.   Journal of Cachexia Sarcopenia and Muscle

CAR directs T cell adaptation to bile acids in the small intestine

(2021) Mei Lan Chen et al.   NATURE

Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs

(2021) Yusuke Kono et al.   Pharmaceutics

Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis

(2021) Sage E. Foley et al.   Microbiome

Combinatorial, additive and dose-dependent drug–microbiome associations

(2021) Sofia K. Forslund et al.   NATURE

Impact of gut microbiota on kidney transplantation

(2021) Poramed Winichakoon et al.   Transplantation Reviews

A comprehensive review of the impact of tacrolimus intrapatient variability on clinical outcomes in kidney transplantation

(2020) Haley M. Gonzales et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Butyric acid normalizes hyperglycemia caused by the tacrolimus‐induced gut microbiota

(2020) Wenjiao Jiao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interaction between drugs and the gut microbiome

(2020) Rinse K Weersma et al.   GUT

Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

(2020) Bahar Javdan et al.   CELL

Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives

(2020) Alexandra Degraeve et al.   Expert Opinion on Drug Metabolism & Toxicology

Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites

(2019) Yukuang Guo et al.   DRUG METABOLISM AND DISPOSITION

Nutritional Management in Renal Transplant Recipients: A transplant team opportunity to improve graft survival

(2019) M. Sabbatini et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Mapping human microbiome drug metabolism by gut bacteria and their genes

(2019) Michael Zimmermann et al.   NATURE

Immunosuppressive effect of the gut microbiome altered by high-dose tacrolimus in mice

(2018) Z. Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

High tacrolimus intra-patient variability is associated with graft rejection, and de novo donor-specific antibodies occurrence after liver transplantation

(2018) Arnaud Del Bello et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein

(2018) Elaine F. Enright et al.   MOLECULAR PHARMACEUTICS

In Vitro Assessment of the Effect of Antiepileptic Drugs on Expression and Function of ABC Transporters and Their Interactions with ABCC2

(2017) Gurpreet Grewal et al.   MOLECULES

The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation

(2017) Nuria Lloberas et al.   Pharmacogenetics and Genomics

Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen

(2017) Gianluigi Zaza et al.   PLoS One

Microbiome Datasets Are Compositional: And This Is Not Optional

(2017) Gregory B. Gloor et al.   Frontiers in Microbiology

Caco-2 cells - expression, regulation and function of drug transporters compared with human jejunal tissue

(2016) S. Brück et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

(2016) Peter Spanogiannopoulos et al.   NATURE REVIEWS MICROBIOLOGY

Pharmacogenetic-based strategy using de novo tacrolimus once daily after kidney transplantation: prospective pilot study

(2016) Martine De Meyer et al.   PHARMACOGENOMICS

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

Intra-patient variability in tacrolimus exposure: Causes, consequences for clinical management

(2015) Nauras Shuker et al.   Transplantation Reviews

Gut Microbiota and Tacrolimus Dosing in Kidney Transplantation

(2015) John R. Lee et al.   PLoS One

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines

(2014) Géraldine Dessilly et al.   PLoS One

Gut Microbial Community Structure and Complications After Kidney Transplantation

(2014) John R. Lee et al.   TRANSPLANTATION

Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients

(2013) Xiao-cong Zuo et al.   Pharmacogenetics and Genomics

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

(2011) Erik Larsson et al.   GUT

Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression

(2011) Dag Henrik Reikvam et al.   PLoS One

Colonization-Induced Host-Gut Microbial Metabolic Interaction

(2011) S. P. Claus et al.   mBio

Clinical Pharmacokinetics of Tacrolimus after the First Oral Administration in Renal Transplant Recipients on Triple Immunosuppressive Therapy

(2010) Radmila M. Velickovic-Radovanovic et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Elevated Tacrolimus Levels Associated With Intravenous Azithromycin and Ceftriaxone: A Case Report

(2010) M.A. Shullo et al.   TRANSPLANTATION PROCEEDINGS

Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1

(2009) S. Tachibana et al.   DRUG METABOLISM AND DISPOSITION

Intestinal flora induces the expression of Cyp3a in the mouse liver

(2009) T. Toda et al.   XENOBIOTICA