Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

(2019) Marion Tible et al.   AGING CELL

MicroRNA in Alzheimer’s disease revisited: implications for major neuropathological mechanisms

(2018) Reihaneh Dehghani et al.   REVIEWS IN THE NEUROSCIENCES

Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition

(2017) Kyoung-Doo Hwang et al.   Molecular Brain

Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway

(2016) Hui Gao et al.   BRAIN BEHAVIOR AND IMMUNITY

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

(2016) J.-S. Zhang et al.   NEUROSCIENCE

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis

(2015) Gerard ILL-Raga et al.   ANTIOXIDANTS & REDOX SIGNALING

PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE  4 Human Replacement Mice

(2015) Y. Segev et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

(2015) Anne-Sophie Carret-Rebillat et al.   Scientific Reports

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

ATF4: a Novel Potential Therapeutic Target for Alzheimer’s Disease

(2014) Na Wei et al.   MOLECULAR NEUROBIOLOGY

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

(2014) Latha Devi et al.   NEUROBIOLOGY OF AGING

The roles of protein expression in synaptic plasticity and memory consolidation

(2014) Tali Rosenberg et al.   Frontiers in Molecular Neuroscience

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease

(2014) Masuo Ohno   Frontiers in Molecular Neuroscience

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer’s Disease

(2013) Julien Dumurgier et al.   PLoS One

Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease

(2013) Latha Devi et al.   PLoS One

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Unfolded protein response

(2012) Stewart Siyan Cao et al.   CURRENT BIOLOGY

ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice

(2012) Yifat Segev et al.   NEUROBIOLOGY OF AGING

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

Arc in synaptic plasticity: from gene to behavior

(2011) Erica Korb et al.   TRENDS IN NEUROSCIENCES

Phosphorylation of eIF2 alpha in Sf9 cells: a stress, survival and suicidal signal

(2010) Iyer Aarti et al.   APOPTOSIS

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

(2010) Cédric Chaveroux et al.   BIOCHIMIE

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

(2010) Anindita Bose et al.   BRAIN PATHOLOGY

TRB3 Function in Cardiac Endoplasmic Reticulum Stress

(2010) Joan Avery et al.   CIRCULATION RESEARCH

eIF2  Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation

(2010) Z. Jiang et al.   JOURNAL OF NEUROSCIENCE

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

(2009) Milena Morel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

(2009) Tatsuya Yoshizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double stranded RNA activated EIF2 α kinase (EIF2AK2; PKR) is associated with Alzheimer's disease

(2007) María J. Bullido et al.   NEUROBIOLOGY OF AGING