ATF4: a Novel Potential Therapeutic Target for Alzheimer’s Disease

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Tau acts as a mediator for Alzheimer's disease-related synaptic deficits

(2014) Dezhi Liao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

(2014) Latha Devi et al.   NEUROBIOLOGY OF AGING

Activating transcription factor 4 (ATF4) modulates post-synaptic development and dendritic spine morphology

(2014) Jin Liu et al.   Frontiers in Cellular Neuroscience

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease

(2014) Masuo Ohno   Frontiers in Molecular Neuroscience

BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42

(2013) Jihoon Nah et al.   Autophagy

Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response

(2013) Ching-Ping Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational regulation of gene expression using the ATF4 oxygen-dependent degradation domain for hypoxia-specific gene therapy

(2013) Su Hee Cho et al.   JOURNAL OF DRUG TARGETING

Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease

(2013) E. Valera et al.   JOURNAL OF NEUROSCIENCE

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease

(2013) Latha Devi et al.   PLoS One

ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway

(2012) Camilla T. Ambivero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional Repression ofATF4Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress Response

(2012) Souvik Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts

(2012) Geum-Hwa Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells

(2012) G. Clavarino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform

(2011) Yishay Shoval et al.   PLoS One

FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1

(2010) René St-Arnaud et al.   Annals of the New York Academy of Sciences

Autophagy impairment stimulates PS1 expression and γ-secretase activity

(2010) Kazunori Ohta et al.   Autophagy

TRB3 Function in Cardiac Endoplasmic Reticulum Stress

(2010) Joan Avery et al.   CIRCULATION RESEARCH

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Neuronal death in Alzheimer’s disease and therapeutic opportunities

(2009) Rossen Donev et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

(2009) Tatsuya Yoshizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation

(2008) C. Dong et al.   LEARNING & MEMORY

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Transfer-NMR and Docking Studies Identify the Binding of the Peptide Derived from Activating Transcription Factor 4 to Protein Ubiquitin Ligase β-TrCP. Competition STD-NMR with β-Catenin†

(2007) Julien Pons et al.   BIOCHEMISTRY