An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases

Harnessing the HDAC–histone deacetylase enzymes, inhibitors and how these can be utilised in tissue engineering

(2019) Liam Lawlor et al.   International Journal of Oral Science

A global scientific strategy to cure hepatitis B

(2019) Peter A Revill et al.   Lancet Gastroenterology & Hepatology

Mapping the Interactions of HBV cccDNA with Host Factors

(2019) Mohd-Ismail et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT2: Controversy and multiple roles in disease and physiology

(2019) Yan Wang et al.   AGEING RESEARCH REVIEWS

HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis

(2018) Sheng-Tao Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV39H1 and SETD1A histone methyltransferases

(2018) Ji-Hua Ren et al.   HEPATOLOGY

Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3β/β-Catenin Signaling Pathway

(2018) Zahra Zahid Piracha et al.   JOURNAL OF VIROLOGY

Parvulin 14 and parvulin 17 bind to HBx and cccDNA and upregulate HBV replication from cccDNA to virion in a HBx-dependent manner

(2018) Umar Saeed et al.   JOURNAL OF VIROLOGY

Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

(2017) Xupeng Hong et al.   HEPATOLOGY

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation

(2017) Wen Zhang et al.   HEPATOLOGY

Novel targets for hepatitis B virus therapy

(2017) Barbara Testoni et al.   LIVER INTERNATIONAL

Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication

(2017) Masashi Iwamoto et al.   Scientific Reports

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state

(2016) Valentina Alarcon et al.   Scientific Reports

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics

(2015) Ju-Tao Guo et al.   ANTIVIRAL RESEARCH

HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase

(2015) Lise Rivière et al.   JOURNAL OF HEPATOLOGY

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

(2015) Junhu Wan et al.   NUCLEIC ACIDS RESEARCH

Molecular biology of hepatitis B virus infection

(2015) Christoph Seeger et al.   VIROLOGY

Sirt2 Deacetylase Is a Novel AKT Binding Partner Critical for AKT Activation by Insulin

(2014) Gopalakrishnan Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DDX3 DEAD-Box RNA Helicase Is a Host Factor That Restricts Hepatitis B Virus Replication at the Transcriptional Level

(2014) C. Ko et al.   JOURNAL OF VIROLOGY

Transcription of Hepatitis B Virus Covalently Closed Circular DNA Is Regulated by CpG Methylation during Chronic Infection

(2014) Yongmei Zhang et al.   PLoS One

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

(2013) Juan Chen et al.   HEPATOLOGY

Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID)

(2013) Koichi Watashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor

(2013) Shirin Nkongolo et al.   JOURNAL OF HEPATOLOGY

Constitutive Nuclear Localization of an Alternatively Spliced Sirtuin-2 Isoform

(2013) Johannes G.M. Rack et al.   JOURNAL OF MOLECULAR BIOLOGY

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

(2012) D. B. Beck et al.   GENES & DEVELOPMENT

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

C-Terminal Substitution of HBV Core Proteins with Those from DHBV Reveals That Arginine-Rich 167RRRSQSPRR175 Domain Is Critical for HBV Replication

(2012) Jaesung Jung et al.   PLoS One

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

(2011) B. Beirowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling

(2010) Antony Hsieh et al.   CANCER LETTERS

Adiponectin, a downstream target gene of peroxisome proliferator-activated receptor γ, controls hepatitis B virus replication

(2010) Sarah Yoon et al.   VIROLOGY

Control of cccDNA function in hepatitis B virus infection

(2009) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

(2009) L. Belloni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic strategies in the management of patients with chronic hepatitis B virus infection

(2007) George V Papatheodoridis et al.   LANCET INFECTIOUS DISEASES