Sirt2 Deacetylase Is a Novel AKT Binding Partner Critical for AKT Activation by Insulin

Diverse Mechanisms of AKT Pathway Activation in Human Malignancy

(2013) Mitchell Cheung et al.   CURRENT CANCER DRUG TARGETS

Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues

(2013) Min Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation

(2013) Natasha T. Snider et al.   JOURNAL OF CELL BIOLOGY

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

Sorting out functions of sirtuins in cancer

(2013) M Roth et al.   ONCOGENE

Targeting PI3K in Cancer: Any Good News?

(2013) Miriam Martini et al.   Frontiers in Oncology

The emerging multiple roles of nuclear Akt

(2012) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

(2012) Simon M. Schultze et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

(2012) Muhammad Ishfaq et al.   FEBS LETTERS

The NAD-dependent deacetylase SIRT2 is required for programmed necrosis

(2012) Nisha Narayan et al.   NATURE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo

(2012) Anna Bobrowska et al.   PLoS One

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

SIRT2 as a Therapeutic Target for Age-Related Disorders

(2012) Rita Machado de Oliveira et al.   Frontiers in Pharmacology

Bimodal regulation of FoxO3 by AKT and 14-3-3

(2011) Melissa Dobson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

(2011) L. Dan et al.   HAEMATOLOGICA

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insulin signal meets SIRT1 at AKT

(2011) Yoshiyuki Horio   Nature Reviews Endocrinology

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

(2008) Ruwin Pandithage et al.   JOURNAL OF CELL BIOLOGY

SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPARγ

(2008) Fei Wang et al.   MOLECULAR BIOLOGY OF THE CELL

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE