Article
Neurosciences
Tal Hoffmann, Katrin Kistner, Sonja L. J. Joksimovic, Slobodan M. Todorovic, Peter W. Reeh, Susanne K. Sauer
Summary: The study evaluated the role of the Ca(V)3.2 T-type calcium channel in painful diabetic neuropathy induced by hyperglycemia, showing significant changes in peripheral C-fiber functions.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Rongzhen Li, Mingxi Ou, Shaomin Yang, Jiabin Huang, Jiamin Chen, Donglin Xiong, Lizu Xiao, Songbin Wu
Summary: Pain is the most common neurological complication of herpes zoster, including postherpetic neuralgia (PHN), and the occurrence and development of PHN are still elusive. However, research has found that VZV may participate in zoster-associated pain by upregulating the expression of Cav3.2 in DRG and SDH, providing a new promising drug target for relieving PHN.
FRONTIERS IN NEUROLOGY
(2021)
Review
Chemistry, Medicinal
Xin Jin, Rilei Yu, Xuemin Wang, Christopher G. Proud, Tao Jiang
Summary: MNKs phosphorylate eIF4E, playing a crucial role in cancer and metabolic diseases. Inhibitors of MNKs can be used for the treatment of various cancers, including solid tumors and leukemia.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Paul M. Ridker, Manas Rane
Summary: IL-6 is a pivotal cytokine in innate immunity with a proatherogenic role in cardiovascular disease. Research has explored mechanisms of IL-6 signaling, murine models, and human epidemiological data regarding its utility as a biomarker of vascular risk.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido
Summary: This study investigated the involvement of IL-6 trans-signaling in DVT and found a strong correlation between the Asp358Ala variant and sIL6-R levels. The high frequency of the Asp358Ala mutation and elevated IL-6 levels in DVT patients may explain the association between IL-6 overactivation and DVT outcome. These findings provide a proof of concept for targeting IL-6 trans-signaling as a new strategy for DVT adjuvant therapy.
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Article
Neurosciences
Juan Sierra-Marquez, Jana Gehlen, Michael Schoeneck, Stefanie Bungert-Pluemke, Antje Willuweit, Carina Balduin, Frank Mueller, Angelika Lampert, Christoph Fahlke, Raul E. E. Guzman
Summary: ClC-3 modifies the electrical activity of peripheral nociceptors and is involved in inflammatory processes in the spinal cord. It regulates the number of ion channels in dorsal root ganglion neurons and is important for the homeostasis of glial cells. Reduced Cl-/H+ exchange contributes to inflammatory responses and affects neuronal excitability.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Physiology
Paulina Villar-Fincheira, Aaron J. Paredes, Tomas Hernandez-Diaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceno, Jorge Mandiola, Nicole Bruneau, Lorena Garcia, Maria Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Summary: The study aims to evaluate the effects of exercise on plasma IL-6 and sIL-6R levels, and their relationship with vascular remodeling. Results show that post-marathon HT athletes had higher post-race plasma sIL-6R levels than LT athletes, suggesting a possible role of IL-6 in vascular remodeling, with a proposed association between IL-6 and aortic dilation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Sarah Rehou, Abdikarim Abdullahi, Marc G. Jeschke
Summary: This study aimed to investigate the role of sIL-6R in burn injury. The results showed that patients with a higher IL-6/sIL-6R ratio had significantly higher mortality. This suggests that IL-6 signaling via its membrane-bound receptor with an anti-inflammatory function is important.
Article
Immunology
Kristen M. Kelly, Jennifer A. Smith, Briana Mezuk
Summary: The study using Mendelian Randomization found a causal relationship between soluble interleukin-6 receptor and depression, potentially through different signaling pathways. The results suggest involvement of the IL-6 signaling pathway in depression and further research is needed.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Anesthesiology
Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Gerald W. Zamponi
Summary: Ca(V)3.2 channels play an important role in trigeminal neuralgia, impacting the occurrence and characteristics of the disease. Mutations in these channels were found in patients, leading to functional changes and exacerbation of pain. By blocking these channels, the severity of pain can be reduced.
Article
Medical Laboratory Technology
Song Cai, Kimberly Gomez, Aubin Moutal, Rajesh Khanna
Summary: CaV3.2 channels play a crucial role in pain processing, with increased expression and activity in various pain models. Targeting proteins that regulate channel trafficking or transcription, as well as those that modify channels via post-translational modifications, may offer new opportunities for pain management.
TRANSLATIONAL RESEARCH
(2021)
Review
Chemistry, Analytical
Marjan Majdinasab, Marc Lamy de la Chapelle, Jean Louis Marty
Summary: Interleukin 6 (IL-6) is a pleiotropic cytokine that exerts pathological pro-inflammatory effects and plays important roles in various biological processes. The detection of IL-6 in small quantities with high selectivity is crucial in medical and biological fields. Conventional laboratory methods such as ELISAs and CLIAs are complex, expensive, and time-consuming, while biosensors offer a simple, rapid, economical, and user-friendly alternative due to their high sensitivity, quick detection time, ease of use, and miniaturization capability.
Article
Anesthesiology
Paulino Barragan-Iglesias, Nikesh Kunder, Andi Wanghzou, Bryan Black, Pradipta R. Ray, Tzu-Fang Lou, June Bryan de la Pena, Rahul Atmaramani, Tarjani Shukla, Joseph J. Pancrazio, Theodore J. Price, Zachary T. Campbell
Summary: The study reveals widespread translation in regions annotated as noncoding in nociceptors, as well as in regulatory regions of mRNAs. A specific uORF-encoded peptide promotes pain sensitization through GPCR signaling.
Review
Pharmacology & Pharmacy
Muhammad Saad Yousuf, Stephanie Shiers, James J. Sahn, Theodore J. Price, Robert Dantzer
Summary: Translation dysregulation is recognized as a characteristic of many diseases, including chronic pain. Current treatments for chronic pain are not effective and have adverse effects, necessitating the development of novel approaches. Pharmacologically targeting specific translation regulation mechanisms may offer promising new treatments for chronic pain disorders by reversing key neuronal phenotypic changes.
PHARMACOLOGICAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Woo Seok Kim, Sungcheol Hong, Milenka Gamero, Vivekanand Jeevakumar, Clay M. Smithhart, Theodore J. Price, Richard D. Palmiter, Carlos Campos, Sung Il Park
Summary: The study introduces a novel wireless optoelectronic device for precise and chronic in vivo optogenetic manipulations of peripheral neural circuits. The research uncovers the role of specific stomach neural fibers in suppressing appetite.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Stephanie Shiers, Ishwarya Sankaranarayanan, Vivek Jeevakumar, Anna Cervantes, Jeffrey C. Reese, Theodore J. Price
Summary: The study found that most nociceptors in humans express multiple markers and exhibit differences in central projection patterns compared to mice. Understanding how human nociceptors connect to subsets of dorsal horn neurons is crucial for understanding the physiological consequences of species differences.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Clinical Neurology
Amanda Avona, Bianca N. Mason, Carolina Burgos-Vega, Anahit H. Hovhannisyan, Sergei N. Belugin, Jennifer Mecklenburg, Vincent Goffin, Naureen Wajahat, Theodore J. Price, Armen N. Akopian, Gregory Dussor
Summary: This study found an interaction between prolactin and CGRP in the meninges of rodents, leading to female-specific migraine behaviors, potentially explaining the higher prevalence of migraines in women.
ANNALS OF NEUROLOGY
(2021)
Editorial Material
Neurosciences
William Renthal, Alexander Chamessian, Michele Curatolo, Steve Davidson, Michael Burton, Sulayman Dib-Hajj, Patrick M. Dougherty, Allison D. Ebert, Robert W. Gereau, Andre Ghetti, Michael S. Gold, Gwendolyn Hoben, Daniela Maria Menichella, Philippe Mercier, Wilson Z. Ray, Daniela Salvemini, Rebecca P. Seal, Stephen Waxman, Clifford J. Woolf, Cheryl L. Stucky, Theodore J. Price
Summary: Chronic pain is a debilitating disease with limited treatment options. Understanding pain cells and networks in humans is crucial for translating knowledge from animal models to therapeutic applications. A multi-institutional collaboration is proposed to address this challenge rigorously and ethically.
Article
Neurosciences
Andi Wangzhou, Candler Paige, Pradipta R. Ray, Gregory Dussor, Theodore J. Price
Summary: Through analysis of single cell RNA sequencing resources from mouse, it was found that somatosensory, sympathetic, and enteric neurons show similar receptor expression diversity to CNS neurons, with greater diversity in GPCRs and cytokine receptors in the PNS. Many receptors were found to be specifically expressed in subsets of PNS neurons, highlighting the complexity of receptor expression in the PNS.
Article
Multidisciplinary Sciences
Tiphaine Voisin, Caroline Perner, Marie-Angele Messou, Stephanie Shiers, Saltanat Ualiyeva, Yoshihide Kanaoka, Theodore J. Price, Caroline L. Sokol, Lora G. Bankova, K. Frank Austen, Isaac M. Chiu
Summary: This study uncovered the role of LTC4 and its receptor CysLT(2)R in inducing itch, providing a promising approach for treating inflammatory itch. The research highlights the importance of targeting CysLT signaling in managing inflammatory itch.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Andi Wangzhou, Candler Paige, Sanjay Neerukonda, Dhananjay K. Naik, Moeno Kume, Eric T. David, Gregory Dussor, Pradipta R. Ray, Theodore J. Price
Summary: The research identified ligand-receptor interactions between sensory neurons and peripheral cells, focusing particularly on the roles of HBEGF and EGFR in disease-associated pain. These findings offer new insights for treating pain and illustrate the complexity of cell-to-neuron signaling in chronic pain states.
Article
Genetics & Heredity
Keira J. A. Johnston, Joey Ward, Pradipta R. Ray, Mark J. Adams, Andrew M. McIntosh, Blair H. Smith, Rona J. Strawbridge, Theodore J. Price, Daniel J. Smith, Barbara Nicholl, Mark E. S. Bailey
Summary: This study found significant differences in chronic pain between males and females, with gender-specific genes and SNPs closely associated with chronic pain. While male and female chronic pain were highly genetically correlated, there were differences between the sexes.
Article
Clinical Neurology
Amanda Avona, Theodore J. Price, Gregory Dussor
Summary: The study found that stimulation of upper body regions with IL-6 can cause widespread hypersensitivity spreading to the paws, but similar stimulation of the lower body does not cause the spread of hypersensitivity into the head. These findings are consistent with whole body hypersensitivity being specific to conditions such as migraine where pain is present in the head.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Article
Neurosciences
Jacob Lackovic, Vivek Jeevakumar, Michael Burton, Theodore J. Price, Gregory Dussor
Summary: Inhibiting the generation of peroxynitrite can alleviate migraine pain induced by dural inflammation. This finding suggests that targeting peroxynitrite may serve as a potential therapy for migraine.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Moeno Kume, Ayesha Ahmad, Stephanie Shiers, Michael D. Burton, Kathryn A. DeFea, Josef Vagner, Gregory Dussor, Scott Boitano, Theodore J. Price
Summary: Given the limited options and harmful side effects of current analgesics, new pain therapeutics are needed. This study describes the development of a novel PAR2 antagonist, C781, which effectively prevents and reverses pain behaviors induced by PAR2 agonists, mast cell activators, and neutrophil elastase in mice. The limited systemic bioavailability of C781 suggests the potential for optimization in future clinical development. This research provides evidence for the efficacy of biased PAR2 antagonists in blocking protease-induced pain, offering a rationale for the development of safer pain treatments targeting PAR2.
Article
Clinical Neurology
Moeno Kume, Ayesha Ahmad, Kathryn A. Defea, Josef Vagner, Gregory Dussor, Scott Boitano, Theodore J. Price
Summary: This study demonstrates the crucial role of PAR2 expressed in sensory neurons in PTX-induced CIPN, suggesting PAR2 as a potential therapeutic target for multiple aspects of PTX CIPN.