Classically activated mouse macrophages produce methylglyoxal that induces a TLR4‐ and RAGE‐independent proinflammatory response

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Gene doubling increases glyoxalase 1 expression in RAGE knockout mice

(2019) Babett Bartling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Activation of Macrophages and Microglia by Interferon–γ and Lipopolysaccharide Increases Methylglyoxal Production: A New Mechanism in the Development of Vascular Complications and Cognitive Decline in Type 2 Diabetes Mellitus?

(2017) Karthik Dhananjayan et al.   JOURNAL OF ALZHEIMERS DISEASE

Advanced glycation end products impair NLRP3 inflammasome–mediated innate immune responses in macrophages

(2017) Seunghwan Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection

(2017) Daniel Prantner et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Induction of mitochondrial apoptotic pathway in triple negative breast carcinoma cells by methylglyoxal via generation of reactive oxygen species

(2017) Anirban Roy et al.   MOLECULAR CARCINOGENESIS

Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway

(2017) Peng Chu et al.   VASCULAR PHARMACOLOGY

Methylglyoxal activates NF-κB nuclear translocation and induces COX-2 expression via a p38-dependent pathway in synovial cells

(2016) Chuan-Chao Lin et al.   LIFE SCIENCES

Generation and characterization of antibodies against arginine-derived advanced glycation endproducts

(2015) Tina Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation

(2015) Shasha Yin et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

S100A9 Induced Inflammatory Responses Are Mediated by Distinct Damage Associated Molecular Patterns (DAMP) Receptors In Vitro and In Vivo

(2015) Bo Chen et al.   PLoS One

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

(2014) Jing Xue et al.   BIOCHEMISTRY

Regulation of methylglyoxal-elicited leukocyte recruitment by endothelial SGK1/GSK3 signaling

(2014) Yang Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism

(2014) K. A. Shirey et al.   JOURNAL OF IMMUNOLOGY

Myricitrin Alleviates Methylglyoxal-Induced Mitochondrial Dysfunction and AGEs/RAGE/NF-κB Pathway Activation in SH-SY5Y Cells

(2014) Yue-Hua Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples

(2014) Naila Rabbani et al.   Nature Protocols

Limited Role of the Receptor for Advanced Glycation End Products duringStreptococcus pneumoniaeBacteremia

(2013) Ahmed Achouiti et al.   Journal of Innate Immunity

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Exploring glyoxalase 1 expression in prostate cancer tissues: Targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties

(2013) Martin Baunacke et al.   PROSTATE

5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential

(2012) Daniel Prantner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete Dependence on IRAK4 Kinase Activity in TLR2, but Not TLR4, Signaling Pathways Underlies Decreased Cytokine Production and Increased Susceptibility to Streptococcus pneumoniae Infection in IRAK4 Kinase-Inactive Mice

(2012) M. E. Pennini et al.   JOURNAL OF IMMUNOLOGY

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

Interferon Regulatory Transcription Factor 3 Protects Mice from Uterine Horn Pathology during Chlamydia muridarum Genital Infection

(2011) Daniel Prantner et al.   INFECTION AND IMMUNITY

Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS

(2011) Y. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38

(2010) Sabine Kuntz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation

(2009) Francesc X. Guix et al.   BRAIN

Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in Sarcoma-180 bearing mice: Involvement of MAP kinase, NF-κβ signal transduction pathway

(2009) Aparajita Pal et al.   MOLECULAR IMMUNOLOGY

Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells

(2008) Hideyuki Yamawaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

The tandem of free radicals and methylglyoxal

(2007) Miklós Péter Kalapos   CHEMICO-BIOLOGICAL INTERACTIONS