Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 54, Issue -, Pages 115-122Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.06.009
Keywords
-
Categories
Funding
- Swiss National Science Foundation [310030-172978]
- Hochspezialisierte Medizin Schwerpunkt Immunologic [HSM-2-Immunologic]
- Swiss National Science Foundation (SNF) [310030_172978] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Type 2 immune responses contribute to the resistance to helminths and toxins as well as several physiological processes. Although they usually do not participate in type 2 immune responses, neutrophils have been shown in mice to enhance the anti-helminth response, but they also contribute to increased target tissue damage. Increased pathology and morbidity is also observed in type 2 immune-mediated disorders, such as allergic asthma, when neutrophils become a predominant subset of the infiltrate. How neutrophil recruitment is regulated during type 2 immune responses is now starting to become clear, with recent data showing that signaling via the prototypic type 2 cytokine interleukin-4 receptor mediates direct and indirect inhibitory actions on neutrophils in mice and humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available