The Influence of Innate Lymphoid Cells and Unconventional T Cells in Chronic Inflammatory Lung Disease

Pulmonary group 2 innate lymphoid cells: surprises and challenges

(2019) Malcolm R. Starkey et al.   Mucosal Immunology

Roles of IL-22 in allergic airway inflammation in mice and humans

(2018) Koichi Hirose et al.   INTERNATIONAL IMMUNOLOGY

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

(2018) Pieter-Paul Hekking et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility

(2018) Ralph Stadhouders et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

(2018) Yuefeng Huang et al.   SCIENCE

Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis

(2018) Barbara C. Mindt et al.   Frontiers in Immunology

Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression

(2018) Neha Vashist et al.   Frontiers in Immunology

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity

(2018) Xi-zhi J. Guo et al.   IMMUNITY

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease

(2018) Chantal Donovan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections

(2018) François Trottein et al.   Frontiers in Immunology

Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: a potential role for the chemokine CXCL16

(2018) Yan Li et al.   Cellular & Molecular Immunology

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

(2017) Yannick Simoni et al.   IMMUNITY

Lung-resident γδ T cells and their roles in lung diseases

(2017) Min Cheng et al.   IMMUNOLOGY

The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice

(2017) Mingyuan Han et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells

(2017) Kangning Zhang et al.   JOURNAL OF IMMUNOLOGY

Protective role of γδ T cells in cigarette smoke and influenza infection

(2017) M J Hong et al.   Mucosal Immunology

Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection

(2017) Jerilyn Gray et al.   Science Translational Medicine

IL-17-producing γδ T cells switch migratory patterns between resting and activated states

(2017) Duncan R. McKenzie et al.   Nature Communications

Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis

(2017) Jong-Uk Lee et al.   BMC Pulmonary Medicine

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

(2017) Medya Mara Shikhagaie et al.   Cell Reports

Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma

(2017) Ayako Ishimori et al.   ALLERGOLOGY INTERNATIONAL

The cellular and molecular determinants of emphysematous destruction in COPD

(2017) Masaru Suzuki et al.   Scientific Reports

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for NontypeableHaemophilus influenzaeInfection

(2016) Timothy S. C. Hinks et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands

(2016) Victor S. Cortez et al.   IMMUNITY

Interleukin-17 Is Required for Control of Chronic Lung Infection Caused by Pseudomonas aeruginosa

(2016) Hannah K. Bayes et al.   INFECTION AND IMMUNITY

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

(2016) Matthew T. Stier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

(2016) Steven G. Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

(2016) Ai Ing Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Eomesodermin Is Sufficient To Direct Type 1 Innate Lymphocyte Development into the Conventional NK Lineage

(2016) Olga Pikovskaya et al.   JOURNAL OF IMMUNOLOGY

IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells

(2016) T Mchedlidze et al.   Mucosal Immunology

The evolution of innate lymphoid cells

(2016) Eric Vivier et al.   NATURE IMMUNOLOGY

NK cells and type 1 innate lymphoid cells: partners in host defense

(2016) Hergen Spits et al.   NATURE IMMUNOLOGY

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

(2016) Yoichiro Ohne et al.   NATURE IMMUNOLOGY

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues

(2016) Yen-Rei A. Yu et al.   PLoS One

Type 2 innate lymphoid cells: at the cross-roads in allergic asthma

(2016) Leonie van Rijt et al.   Seminars in Immunopathology

Allergen-Dependent Differences in ILC2s Frequencies in Patients With Allergic Rhinitis

(2016) Dachuan Fan et al.   Allergy Asthma & Immunology Research

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung

(2016) Katrien C. De Grove et al.   PLoS One

Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

(2015) B. Liao et al.   ALLERGY

Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia

(2015) J. Ho et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice

(2015) Steven Bozinovski et al.   CLINICAL SCIENCE

Mucosal-Associated Invariant T Cell Deficiency in Chronic Obstructive Pulmonary Disease

(2015) Yong Soo Kwon et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

(2015) Timothy S.C. Hinks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis

(2015) A Mohapatra et al.   Mucosal Immunology

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

(2015) G. Gasteiger et al.   SCIENCE

Lung ILC2s link innate and adaptive responses in allergic inflammation

(2015) Itziar Martinez-Gonzalez et al.   TRENDS IN IMMUNOLOGY

IL-22 Defect During Streptococcus pneumoniae Infection Triggers Exacerbation of Chronic Obstructive Pulmonary Disease

(2015) Muriel Pichavant et al.   EBioMedicine

Association between Group 2 Innate Lymphoid Cells enrichment, nasal polyps and allergy in Chronic Rhinosinusitis

(2014) D. Miljkovic et al.   ALLERGY

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma ExacerbationsIn Vivo

(2014) David J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness

(2014) Hannah H. Walford et al.   CLINICAL IMMUNOLOGY

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

Development, Differentiation, and Diversity of Innate Lymphoid Cells

(2014) Andreas Diefenbach et al.   IMMUNITY

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

(2014) Kathleen R. Bartemes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells

(2014) Jun Young Hong et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR + ILC3 in Lesional Skin and Blood of Psoriasis Patients

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells

(2014) Yuefeng Huang et al.   NATURE IMMUNOLOGY

Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

(2014) Christine M. Freeman et al.   PLoS One

Role of CC Chemokine Receptor 4 in Natural Killer Cell Activation during Acute Cigarette Smoke Exposure

(2013) Valerie R. Stolberg et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps

(2013) Joanne L. Shaw et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Influence of Cigarette Smoking on Viral Infections

(2013) Carla M.T. Bauer et al.   CHEST

Distribution of T-Cell Subsets in BAL Fluid of Patients With Mild to Moderate COPD Depends on Current Smoking Status and Not Airway Obstruction

(2013) Helena Forsslund et al.   CHEST

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis

(2013) M Pichavant et al.   Mucosal Immunology

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Differential Activation of Killer Cells in the Circulation and the Lung: A Study of Current Smoking Status and Chronic Obstructive Pulmonary Disease (COPD)

(2013) Jia Wang et al.   PLoS One

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

(2013) E. Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection

(2013) Stacey Ann Gorski et al.   PLoS Pathogens

Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma

(2012) Roel G. J. Klein Wolterink et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave

(2012) Jan D. Haas et al.   IMMUNITY

NKG2D Mediates NK Cell Hyperresponsiveness and Influenza-Induced Pathologies in a Mouse Model of Chronic Obstructive Pulmonary Disease

(2012) B. W. Wortham et al.   JOURNAL OF IMMUNOLOGY

Distribution of γδ and other T-lymphocyte subsets in patients with chronic obstructive pulmonary disease and asthma

(2012) Daiva Urboniene et al.   RESPIRATORY MEDICINE

Enhanced cytotoxic function of natural killer and natural killer T-like cells associated with decreased CD94 (Kp43) in the chronic obstructive pulmonary disease airway

(2012) GREG HODGE et al.   RESPIROLOGY

Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines

(2012) Hiroshi Watarai et al.   PLOS BIOLOGY

Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A

(2011) Anne-Gaelle Besnard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity

(2011) Hye Young Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease

(2011) Christian Taube et al.   PLoS One

Invariant natural killer T cells in chronic obstructive pulmonary disease

(2011) SU YOUNG CHI et al.   RESPIROLOGY

Innate and Adaptive Interleukin-17–producing Lymphocytes in Chronic Inflammatory Lung Disorders

(2010) Bart M. Vanaudenaerde et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Interleukin-22 is a negative regulator of the allergic response

(2010) Bruno Schnyder et al.   CYTOKINE

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

Interleukin-1β Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue

(2010) Tiffany Hughes et al.   IMMUNITY

Natural killer T cells are important in the pathogenesis of asthma: The many pathways to asthma

(2010) Dale T. Umetsu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased IL-33 expression by epithelial cells in bronchial asthma

(2010) David Préfontaine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic Cigarette Smoke Exposure Primes NK Cell Activation in a Mouse Model of Chronic Obstructive Pulmonary Disease

(2010) G. T. Motz et al.   JOURNAL OF IMMUNOLOGY

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1  reveals intrinsic functional plasticity

(2010) M. Cella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22

(2009) T. Hughes et al.   BLOOD

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients

(2009) A. Di Stefano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Influence of Smoking Cessation on Airway T Lymphocyte Subsets in COPD

(2009) Ester Roos-Engstrand et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility

(2009) Arnoldo Aquino-Galvez et al.   HUMAN GENETICS

Inverse association of peripheral blood CD4+ invariant natural killer T cells with atopy in human asthma

(2009) Young-Il Koh et al.   HUMAN IMMUNOLOGY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-33 overexpression is associated with liver fibrosis in mice and humans

(2009) Pierrick Marvie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease

(2009) Michael T. Borchers et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-17A-Expressing T Cells Are Essential for Bacterial Clearance in a Murine Model of Hypersensitivity Pneumonitis

(2009) Philip L. Simonian et al.   JOURNAL OF IMMUNOLOGY

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

(2008) Y. Kondo et al.   INTERNATIONAL IMMUNOLOGY

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE