Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases

Drug Retention Rate and Predictive Factors of Drug Survival for Interleukin-1 Inhibitors in Systemic Juvenile Idiopathic Arthritis

(2019) Jurgen Sota et al.   Frontiers in Pharmacology

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

(2019) Xiaoyu Liu et al.   IMMUNITY

Conditioning electrical stimulation promotes functional nerve regeneration

(2019) Jenna-Lynn Senger et al.   EXPERIMENTAL NEUROLOGY

Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy

(2019) Hao Luo et al.   Cell Reports

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

IL-1β enables CNS access to CCR2himonocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

(2018) Alexandre Paré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Cytokines and Their Receptors in Inflammatory Pain

(2018) Andrew D. Cook et al.   TRENDS IN IMMUNOLOGY

Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells

(2018) Anping Song et al.   Scientific Reports

Sensory Afferents Use Different Coding Strategies for Heat and Cold

(2018) Feng Wang et al.   Cell Reports

Microglia and CNS Interleukin-1: Beyond Immunological Concepts

(2018) Xiaoyu Liu et al.   Frontiers in Neurology

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner

(2018) Sampurna Chakrabarti et al.   NEUROPHARMACOLOGY

Interleukin-1β signaling in osteoarthritis – chondrocytes in focus

(2018) Zsuzsa Jenei-Lanzl et al.   CELLULAR SIGNALLING

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis

(2017) B.H. He et al.   OSTEOARTHRITIS AND CARTILAGE

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis

(2017) S.C.M. van Dalen et al.   OSTEOARTHRITIS AND CARTILAGE

Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study

(2017) S.X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis

(2017) Sonia Nasi et al.   Frontiers in Pharmacology

IL‐1 signaling is critical for expansion but not generation of autoreactive GM‐CSF + Th17 cells

(2016) Ilgiz A Mufazalov et al.   EMBO JOURNAL

Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

(2016) Sébastien A. Lévesque et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pain in autoimmune disorders

(2016) Katherine A. Mifflin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

(2016) K. Koda et al.   OSTEOARTHRITIS AND CARTILAGE

Long-Lasting Activation of the Transcription Factor CREB in Sensory Neurons by Interleukin-1β During Antigen-Induced Arthritis in Rats: A Mechanism of Persistent Arthritis Pain?

(2016) Gisela Segond von Banchet et al.   Arthritis & Rheumatology

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis

(2015) Éva Borbély et al.   BRAIN BEHAVIOR AND IMMUNITY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types

(2015) X. Liu et al.   JOURNAL OF NEUROSCIENCE

NeuroPep: a comprehensive resource of neuropeptides

(2015) Y. Wang et al.   Database-The Journal of Biological Databases and Curation

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

(2015) Hugues Petitjean et al.   Cell Reports

A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

(2015) Yasunobu Arima et al.   eLife

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Mechanisms, impact and management of pain in rheumatoid arthritis

(2014) David A. Walsh et al.   Nature Reviews Rheumatology

Melanocortin 1 Receptor-Signaling Deficiency Results in an Articular Cartilage Phenotype and Accelerates Pathogenesis of Surgically Induced Murine Osteoarthritis

(2014) Julia Lorenz et al.   PLoS One

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

(2014) Aline Dumas et al.   PLoS Pathogens

Defining the nociceptor transcriptome

(2014) Matthew Thakur et al.   Frontiers in Molecular Neuroscience

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

Endogenous Interleukin-1β in Neuropathic Rats Enhances Glutamate Release from the Primary Afferents in the Spinal Dorsal Horn through Coupling with PresynapticN-Methyl-d-aspartic Acid Receptors

(2013) Xisheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier

(2012) Yasunobu Arima et al.   CELL

P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

(2012) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Estimating Efficacy and Drug ED50's Using von Frey Thresholds: Impact of Weber's Law and Log Transformation

(2012) Charles Mills et al.   JOURNAL OF PAIN

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation

(2012) Roxanne Y. Walder et al.   PAIN

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Neuron-Specific Effects of Interleukin-1  Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Functional Recovery after Peripheral Nerve Injury is Dependent on the Pro-Inflammatory Cytokines IL-1  and TNF: Implications for Neuropathic Pain

(2011) S. Nadeau et al.   JOURNAL OF NEUROSCIENCE

Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis

(2011) Gabriele Musumeci et al.   NEUROBIOLOGY OF DISEASE

What makes osteoarthritis painful? The evidence for local and central pain processing

(2011) N. Sofat et al.   RHEUMATOLOGY

Neutrophils in a mouse model of autoantibody-mediated arthritis: Critical producers of Fc receptor γ, the receptor for C5a, and lymphocyte function−associated antigen 1

(2010) Paul A. Monach et al.   ARTHRITIS AND RHEUMATISM

Endothelial IL-1R1 is a critical mediator of EAE pathogenesis

(2010) Qiming Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Intravital Imaging of IL-1β Production in Skin

(2010) Hironori Matsushima et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis

(2010) Christina A. Christianson et al.   PAIN

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1

(2009) Dirk E. Smith et al.   IMMUNITY

IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis

(2009) E. E. McCandless et al.   JOURNAL OF IMMUNOLOGY

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

Assessment of Movement-Evoked Pain in Osteoarthritis by the Knee-Bend and CatWalk Tests: A Clinically Relevant Study

(2008) Joana Ferreira-Gomes et al.   JOURNAL OF PAIN

Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)

(2008) Camille J. Olechowski et al.   PAIN