How to use macrophages to realise the treatment of tumour

Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα

(2020) Brandon H. Hayes et al.   JOURNAL OF CELL SCIENCE

Transmembrane TNFα-Expressed Macrophage Membrane-Coated Chitosan Nanoparticles as Cancer Therapeutics

(2020) Srirupa Bhattacharyya et al.   ACS Omega

Paclitaxel-Loaded Macrophage Membrane Camouflaged Albumin Nanoparticles for Targeted Cancer Therapy

(2020) Xi Cao et al.   International Journal of Nanomedicine

Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer

(2020) Rui Liu et al.   JOURNAL OF CONTROLLED RELEASE

The role of Clusterin in cancer metastasis

(2019) Mei Peng et al.   Cancer Management and Research

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

(2019) Christina Schindler et al.   PLoS One

The emerging roles of macrophages in cancer metastasis and response to chemotherapy

(2019) Luis Rivera Sanchez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lactate secreted by cervical cancer cells modulates macrophage phenotype

(2019) Simone Cardozo Stone et al.   JOURNAL OF LEUKOCYTE BIOLOGY

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3

(2019) Di Liu et al.   CELL RESEARCH

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

(2019) Christopher J. Halbrook et al.   Cell Metabolism

Phase I Study of Emactuzumab Single Agent or in Combination with Paclitaxel in Patients with Advanced/Metastatic Solid Tumors Reveals Depletion of Immunosuppressive M2-like Macrophages

(2019) C A Gomez-Roca et al.   ANNALS OF ONCOLOGY

Iron oxide nanoparticles promote macrophage autophagy and inflammatory response through activation of toll-like Receptor-4 signaling

(2019) Rongrong Jin et al.   BIOMATERIALS

M2-like tumor-associated macrophages-secreted EGF promotes epithelial ovarian cancer metastasis via activating EGFR-ERK signaling and suppressing lncRNA LIMT expression

(2019) Xiang-Yang Zeng et al.   CANCER BIOLOGY & THERAPY

Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis

(2019) Dilip K. Challa et al.   mAbs

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma

(2019) Marcus Noel et al.   INVESTIGATIONAL NEW DRUGS

A novel macrophage-mediated biomimetic delivery system with NIR-triggered release for prostate cancer therapy

(2019) Lei Qiang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

(2019) Chanju Lee et al.   Journal for ImmunoTherapy of Cancer

IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling

(2019) Andrew C. Little et al.   Frontiers in Oncology

Saikosaponin D loaded macrophage membrane-biomimetic nanoparticles target angiogenic signaling for breast cancer therapy

(2019) Kaiju Sun et al.   Applied Materials Today

Multifunctional Bi@PPy-PEG Core–Shell Nanohybrids for Dual-Modal Imaging and Photothermal Therapy

(2018) Sisi Yang et al.   ACS Applied Materials & Interfaces

Thiol-capped Bi nanoparticles as stable and all-in-one type theranostic nanoagents for tumor imaging and thermoradiotherapy

(2018) Nuo Yu et al.   BIOMATERIALS

Blocking “don't eat me” signal of CD47-SIRPα in hematological malignancies, an in-depth review

(2018) Atlantis Russ et al.   BLOOD REVIEWS

Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity

(2018) Curtis J. Perry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

(2018) Yu Zhang et al.   NANO LETTERS

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy

(2018) Qian-Fang Meng et al.   NANOTECHNOLOGY

Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy

(2018) Xudong Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

(2018) David K. Edwards V et al.   Oncotarget

C–C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer

(2018) Hongjuan Zhao et al.   ACS Applied Materials & Interfaces

Tumor-associated macrophages secrete CCL2 and induce the invasive phenotype of human breast epithelial cells through upregulation of ERO1-α and MMP-9

(2018) Seungeun Lee et al.   CANCER LETTERS

Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery

(2018) Weizhong Zhang et al.   ADVANCED MATERIALS

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Macrophage ghost entrapped amphotericin B: a novel delivery strategy towards experimental visceral leishmaniasis

(2018) Prakash Kumar et al.   Drug Delivery and Translational Research

The roles of CSFs on the functional polarization of tumor-associated macrophages

(2017) Pascale Jeannin et al.   FEBS Journal

In vitro photodynamic effects of scavenger receptor targeted-photoactivatable nanoagents on activated macrophages

(2017) Bong Gu Yi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mannose Receptor Mediates the Immune Response to Ganoderma atrum Polysaccharides in Macrophages

(2017) Wen-Juan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

(2017) Peiming Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

(2017) Yulei Chen et al.   Journal of Hematology & Oncology

The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation

(2017) Toyohisa Iriki et al.   LUNG CANCER

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

(2017) Soracha Thamphiwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Superhydrophobic Coatings with Periodic Ring Structured Patterns for Self-Cleaning and Oil-Water Separation

(2017) Yongjin Wang et al.   Advanced Materials Interfaces

Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications

(2017) Mariona Cabo et al.   OncoImmunology

Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged Circulation Life and Enhanced Cancer Photothermal Therapy

(2016) Mingjun Xuan et al.   ACS Applied Materials & Interfaces

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

(2016) Haiqiang Cao et al.   ACS Nano

Gold-Nanosponge-Based Multistimuli-Responsive Drug Vehicles for Targeted Chemo-Photothermal Therapy

(2016) Tingting Zheng et al.   ADVANCED MATERIALS

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding

(2016) Penka S. Petrova et al.   CLINICAL CANCER RESEARCH

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer

(2016) Aldema Sas‐Chen et al.   EMBO Molecular Medicine

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Synthetic nanoparticles camouflaged with biomimetic erythrocyte membranes for reduced reticuloendothelial system uptake

(2016) Lang Rao et al.   NANOTECHNOLOGY

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

An Open-Label, Multicenter, Phase I/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma

(2015) B. von Tresckow et al.   CLINICAL CANCER RESEARCH

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer

(2015) Jijun Fu et al.   JOURNAL OF CONTROLLED RELEASE

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy

(2015) Minjun Xuan et al.   Advanced Healthcare Materials

Antitumor activity and safety of combination therapy with the Toll-like receptor 9 agonist IMO-2055, erlotinib, and bevacizumab in advanced or metastatic non-small cell lung cancer patients who have progressed following chemotherapy

(2014) David A. Smith et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Functional Nanomaterials for Phototherapies of Cancer

(2014) Liang Cheng et al.   CHEMICAL REVIEWS

Cell-mediated delivery of nanoparticles: Taking advantage of circulatory cells to target nanoparticles

(2014) Aaron C. Anselmo et al.   JOURNAL OF CONTROLLED RELEASE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study

(2014) Irene Brana et al.   Targeted Oncology

Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions

(2014) Fabio Morandi et al.   Frontiers in Immunology

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

The role of immune-related myeloid cells in angiogenesis

(2013) Sarah E.J. Chambers et al.   IMMUNOBIOLOGY

KIT oncogene inhibition drives intratumoral macrophage M2 polarization

(2013) Michael J. Cavnar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

(2013) Mercedes Lobera et al.   Nature Chemical Biology

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Macrophages as potential targets for zoledronic acid outside the skeleton—evidence from in vitro and in vivo models

(2013) T. L. Rogers et al.   CELLULAR ONCOLOGY

Macrophages and chemokines as mediators of angiogenesis

(2013) Jennifer L. Owen et al.   Frontiers in Physiology

Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors

(2013) Robert H. Vonderheide et al.   OncoImmunology

Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies

(2012) Brenda J. Weigel et al.   AMERICAN JOURNAL OF HEMATOLOGY

Use of macrophages to deliver therapeutic and imaging contrast agents to tumors

(2012) Jinhyang Choi et al.   BIOMATERIALS

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

(2012) Massimo Zollo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer

(2012) S. Adams et al.   CLINICAL CANCER RESEARCH

Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

(2012) Matthew Basel et al.   International Journal of Nanomedicine

Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages

(2012) Nina Linde et al.   JOURNAL OF PATHOLOGY

A Cell-Delivered and Cell-Activated SN38-Dextran Prodrug Increases Survival in a Murine Disseminated Pancreatic Cancer Model

(2012) Matthew T. Basel et al.   Small

Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

(2012) Hongwang Wang et al.   Beilstein Journal of Nanotechnology

Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma

(2011) Toshifumi Fujiwara et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cell-mediated drug delivery

(2011) Elena V Batrakova et al.   Expert Opinion on Drug Delivery

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

(2011) Zhen Huang et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors

(2010) Seth B. Coffelt et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Shigella Mediated Depletion of Macrophages in a Murine Breast Cancer Model Is Associated with Tumor Regression

(2010) Katharina Galmbacher et al.   PLoS One

Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution

(2009) Maria Luisa Bondì et al.   Nanomedicine

Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas

(2009) Darya Alizadeh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor Activity of Liposomal Prednisolone Phosphate Depends on the Presence of Functional Tumor-Associated Macrophages in Tumor Tissue

(2008) Manuela Banciu et al.   NEOPLASIA