Article
Biochemistry & Molecular Biology
Dong Zhan, Andrew Cross, Helen L. Wright, Robert J. Moots, Steven W. Edwards, Sittisak Honsawek
Summary: Neutrophil-derived microvesicles (NDMVs) have the potential to exert anti-inflammatory effects by inhibiting broad-spectrum proinflammatory cytokine secretion stimulated by TNF alpha in fibroblast-like synoviocytes. This suggests a potential therapeutic role of NDMVs in regulating the function of synoviocytes in rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Juliana P. Vago, Natalia Valdrighi, Esmeralda N. Blaney-Davidson, Daniel L. A. H. Hornikx, Margot Neefjes, Maria E. Barba-Sarasua, Nathalie G. M. Thielen, Martijn H. J. van den Bosch, Peter M. van der Kraan, Marije I. Koenders, Flavio A. Amaral, Fons A. J. van de Loo
Summary: This study investigated the anti-inflammatory effects of Gas6, a TAM receptor ligand, in synovial fibroblasts from osteoarthritis (OA) patients. Gas6 was found to reduce the levels of inflammatory markers, and its effects depended on the activation of the Axl receptor and the induction of SOCS1/3.
Article
Biochemistry & Molecular Biology
Jakub Chwastek, Marta Kedziora, Malgorzata Borczyk, Michal Korostynski, Katarzyna Starowicz
Summary: Osteoarthritis is a common joint pathology in developed countries and a major cause of disability. This study found that synoviocytes, which build the joint membrane, contribute to the development of osteoarthritis. The synoviocytes of osteoarthritis patients show an enhanced response to inflammatory factors and secrete proteins that may promote disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Liang Ding, Taiyang Liao, Nan Yang, Yibao Wei, Runlin Xing, Peng Wu, Xiaochen Li, Jun Mao, Peimin Wang
Summary: This study showed that chrysin, a natural flavonoid, can improve synovitis and fibrosis in knee osteoarthritis (KOA) through the PERK/TXNIP/NLRP3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jie Yang, Shanshan Li, Zhenyan Li, Lutian Yao, Meijing Liu, Kui-Leung Tong, Qiutong Xu, Bo Yu, Rui Peng, Tao Gui, Wang Tang, Yidi Xu, Jiaxu Chen, Jun He, Kewei Zhao, Xiaogang Wang, Xiaoying Wang, Zhengang Zha, Huan-Tian Zhang
Summary: The enrichment of M1 macrophages and enhanced glycolysis of fibroblast-like synoviocytes (FLSs) play key roles in the pathogenesis of diabetic osteoarthritis (DOA). The yes-associated protein 1 (YAP1)/thioredoxin-interacting protein (TXNIP) signaling axis regulates the glycolysis of FLSs, which fine-tunes the recruitment and infiltration of M1 macrophages. Furthermore, M1 macrophage membrane-camouflaged verteporfin (Vt)-loaded nanoparticles significantly alleviate DOA by suppressing the YAP1/TXNIP signaling-regulated synovial glycolysis and M1 macrophage infiltration.
Article
Immunology
Ruina Kong, Lianmei Ji, Yafei Pang, Dongbao Zhao, Jie Gao
Summary: This study demonstrates that exosomal miR-19b-3p from osteoarthritis fibroblast-like synoviocytes enhances cartilage ferroptosis and damage by regulating SLC7A11, suggesting a potential link among synovium, cartilage, and ferroptosis during osteoarthritis progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Anca Maglaviceanu, Brian Wu, Mohit Kapoor
Summary: This review discusses the activation of fibroblast-like synoviocytes and their role in driving fibrotic responses in osteoarthritis, as well as the impact of myofibroblast-like cells on the structure of the synovial membrane.
WOUND REPAIR AND REGENERATION
(2021)
Article
Cell Biology
K. Kornicka-Garbowska, S. Groborz, B. Lynda, L. Galuppo, K. Marycz
Summary: This study demonstrates that mitochondrial transfer can significantly modulate the proliferative and metabolic activity of synovial cells in synovitis, presenting a potential therapeutic effect.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Thomas Timm, Christiane Hild, Gerhard Liebisch, Markus Rickert, Guenter Lochnit, Juergen Steinmeyer
Summary: The levels of lysophosphatidylcholine (LPC) are elevated in the synovial fluid of patients with osteoarthritis (OA). Different LPC species have varying effects on the regulation of proteins and phospholipids in fibroblast-like synoviocytes (FLSs). IL-1 & beta; has the most significant impact on the regulation of proteins by LPC 16:0, suggesting its potential role in modulating inflammatory and catabolic mechanisms.
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Tachatra Ungsudechachai, Sittisak Honsawek, Jiraphun Jittikoon, Wanvisa Udomsinprasert
Summary: This study investigated the role of clusterin (CLU), a multifaceted chaperone-like protein, in knee osteoarthritis (OA) patients. The study found that CLU protein and mRNA levels were associated with synovitis severity and that CLU could inhibit IL-1 beta-induced inflammation and extracellular matrix degradation through the PI3K/Akt signaling pathway. These findings suggest that CLU may have therapeutic potential for synovitis and cartilage destruction in knee OA.
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
X. Du, Z. Jiang, G. Fang, R. Liu, X. Wen, Y. Wu, S. Hu, Z. Zhang
Summary: This study aimed to investigate the role and mechanism of meniscal cell lysate (MCL) in fibroblast-like synoviocytes (FLSs) and osteoarthritis (OA). MCL was found to be substantially enriched in the synovial fluid of OA patients, promoting the release of inflammatory cytokines from FLSs through MCL phagocytosis. ANT3 was up-regulated in MCL and OA-FLSs, corresponding to impaired mitochondrial function and cell viability. Silencing ANT3 restored mitochondrial homeostasis, alleviating synovial inflammation and preventing early-stage OA.
BONE & JOINT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Guomin Ren, Nedaa Al-Jezani, Pamela Railton, James N. Powell, Roman J. Krawetz
Summary: Studies have shown that CCL22 has pro-inflammatory effects on fibroblast-like synoviocytes, suppressing IL-4 and IL-10 expression while promoting S100A12 expression. The response of synoviocytes to CCL22 is not dependent on the disease state of the joint, but is correlated with the individual's synovial fluid level of CCL22. CCL22 induction of S100A12 in synoviocytes is attenuated after knockdown of CCR3, indicating a potential feedforward pro-inflammatory mechanism.
Review
Medicine, General & Internal
Li Zhang, Runlin Xing, Zhengquan Huang, Liang Ding, Li Zhang, Mingchao Li, Xiaochen Li, Peimin Wang, Jun Mao
Summary: Research on osteoarthritis has traditionally focused on bone changes, but studies on synovitis have only increased in the past decade. Current understanding suggests that osteoarthritis involves various joint tissues, including nerve sprouting, pannus formation, and changes in the synovial matrix. These factors contribute to synovial fibrosis, potentially linked to clinical symptoms like pain, hyperalgesia, and stiffness in osteoarthritis.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Olivier Malaise, Genevieve Paulissen, Celine Deroyer, Federica Ciregia, Christophe Poulet, Sophie Neuville, Zelda Plener, Christophe Daniel, Philippe Gillet, Chantal Lechanteur, Jean-Marc Brondello, Dominique de Seny, Michel Malaise
Summary: It was found that the use of glucocorticoids did not induce an apparent senescence phenotype in FLS and MSC from OA patients, even leading to increased proliferation in some cases, without causing DNA damage and reducing p21mRNA expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jiajie Tu, Yawei Guo, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Korner, Wei Wei
FRONTIERS IN PHARMACOLOGY
(2019)
Review
Endocrinology & Metabolism
Jiajie Tu, Albert Hoi-Hung Cheung, Clement Leung-Kwok Chan, Wai-Yee Chan
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Rheumatology
Yilong Fang, Jiajie Tu, Dafei Han, Yawei Guo, Wenming Hong, Wei Wei
Article
Cell Biology
Jiajie Tu, Chao Wan, Fengjie Zhang, Lianbao Cao, Patrick Wai Nok Law, Yuyao Tian, Gang Lu, Owen M. Rennert, Wai-Yee Chan, Hoi-Hung Cheung
Review
Cell Biology
Jiajie Tu, Xinming Wang, Xun Gong, Wenming Hong, Dafei Han, Yilong Fang, Yawei Guo, Wei Wei
MEDIATORS OF INFLAMMATION
(2020)
Article
Oncology
Yawei Guo, Wenming Hong, Pengying Zhang, Dafei Han, Yilong Fang, Jiajie Tu, Wei Wei
Review
Reproductive Biology
Jiajie Tu, Yu Chen, Zhe Li, Huan Yang, He Chen, Zhiying Yu
JOURNAL OF OVARIAN RESEARCH
(2020)
Correction
Cell Biology
Jiajie Tu, Chao Wan, Fengjie Zhang, Lianbao Cao, Patrick Wai Nok Law, Yuyao Tian, Gang Lu, Owen M. Rennert, Wai-Yee Chan, Hoi-Hung Cheung
Article
Medicine, Research & Experimental
Jiaji Tu, Wei Huang, Weiwei Zhang, Jiawei Mei, Zhiying Yu, Chen Zhu
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Review
Cell Biology
Jiajie Tu, Yilong Fang, Dafei Han, Xuewen Tan, Haifeng Jiang, Xun Gong, Xinming Wang, Wenming Hong, Wei Wei
Summary: Glioma is the most common primary intracranial tumor, and it is closely associated with significant angiogenesis. Activation of NF-kappa B plays a crucial role in the growth and progression of glioma angiogenesis, making it a rational therapeutic target for antiangiogenic strategies aimed at gliomas.
CELL PROLIFERATION
(2021)
Article
Medicine, Research & Experimental
Yizhao Chen, Zhiying Yu, Xuewen Tan, Haifeng Jiang, Zhen Xu, Yilong Fang, Dafei Han, Wenming Hong, Wei Wei, Jiajie Tu
Summary: CAR-M therapy shows potential in targeting solid tumors, but there are limitations that need further research to enhance its therapeutic efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Xuewen Tan, Haifeng Jiang, Yilong Fang, Dafei Han, Yawei Guo, Xinming Wang, Xun Gong, Wenming Hong, Jiajie Tu, Wei Wei
Summary: This review discusses the roles and mechanisms of long non-coding RNA GAS5 in glioma, suggesting it may serve as a biomarker for diagnosis, prognosis, and even a potential target for treatment. Further investigation into the potential of GAS5 in glioma is warranted.
Article
Immunology
Xinming Wang, Jiajie Tu, Ji Jiang, Qiaolin Zhang, Qi Liu, Heinrich Korner, Jingjing Wu, Huaxun Wu, Wei Wei
JOURNAL OF IMMUNOLOGY
(2020)
Review
Medicine, Research & Experimental
Jiajie Tu, Wei Huang, Weiwei Zhang, Jiawei Mei, Chen Zhu
BIOMEDICINE & PHARMACOTHERAPY
(2020)