CAR-macrophage: A new immunotherapy candidate against solid tumors

Apoptotic Cells Reprogram Resident Macrophages to Support Chimeric Antigen Receptor (CAR) T Cell Therapy Against Peritoneal Solid Tumor

(2020) Dror Mevorach   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CD19/CD22 chimeric antigen receptor T-cell therapy for refractory acute B-cell lymphoblastic leukemia with FLT3-ITD mutations

(2020) Aiyun Jin et al.   BONE MARROW TRANSPLANTATION

A review of cancer immunotherapy toxicity

(2020) Lucy Boyce Kennedy et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Combination of Oncolytic Virotherapy and CAR T/NK Cell Therapy for the Treatment of Cancer

(2020) G. V. Kochneva et al.   MOLECULAR BIOLOGY

Cancer-eating immune cells kitted out with CARs

(2020) Elie Dolgin   NATURE BIOTECHNOLOGY

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

(2020) Junyun Lai et al.   NATURE IMMUNOLOGY

Macrophages get a CAR

(2020) M. Teresa Villanueva   NATURE REVIEWS DRUG DISCOVERY

Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells

(2020) Rowa Y. Alhabbab   Frontiers in Genetics

Macrophages enter CAR immunotherapy

(2020) Madhura Mukhopadhyay   NATURE METHODS

Chimeric antigen receptor engineered innate immune cells in cancer immunotherapy

(2019) Chu Lin et al.   Science China-Life Sciences

Immune checkpoints in the tumor microenvironment

(2019) Salman M. Toor et al.   SEMINARS IN CANCER BIOLOGY

Engineering macrophages to phagocytose cancer cells by blocking the CD47/SIRPɑ axis

(2019) Hongcheng Yang et al.   Cancer Medicine

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix

(2019) Wenlong Zhang et al.   BRITISH JOURNAL OF CANCER

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

(2019) Xiaolei Li et al.   Molecular Cancer

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Macrophage targeting: opening new possibilities for cancer immunotherapy

(2018) Luca Cassetta et al.   IMMUNOLOGY

Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T

(2018) Dok Yoon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

Macrophages: The Road Less Traveled, Changing Anticancer Therapy

(2018) Jennifer L. Guerriero   TRENDS IN MOLECULAR MEDICINE

Chimeric antigen receptors that trigger phagocytosis

(2018) Meghan A Morrissey et al.   eLife

Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

(2018) Paris Kosti et al.   Frontiers in Immunology

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management

(2018) Jennifer N. Brudno et al.   BLOOD REVIEWS

Macrophages hold the key to cancer’s inner sanctum

(2018) Gerald L. Wolf   MEDICAL HYPOTHESES

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-CD19 Chimeric Antigen Receptor T Cell Therapies: Harnessing the Power of the Immune System to Fight Diffuse Large B Cell Lymphoma

(2018) Robert Havard et al.   Current Hematologic Malignancy Reports

Engineering macrophages to eat cancer: from “marker of self” CD47 and phagocytosis to differentiation

(2017) Cory Alvey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Engineering Natural Killer Cells for Cancer Immunotherapy

(2017) Katayoun Rezvani et al.   MOLECULAR THERAPY

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

(2017) Congcong Zhang et al.   Frontiers in Immunology

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

Diverse macrophages polarization in tumor microenvironment

(2016) Inmoo Rhee   ARCHIVES OF PHARMACAL RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

(2011) Zhen Huang et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY