Article
Biophysics
Sajedeh Khorshidi, Reza Karimi-Soflou, Akbar Karkhaneh
Summary: A hydrogel/particle scaffold with a gradient of oxygen releasing microparticles was developed in the study, showing significant improvements in cell viability and density. The gradient oxygen releasing composite exhibited different impacts on osteogenesis and chondrogenesis of mesenchymal stem cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Fong Chen, Yi-Chun Chen, Yu-Show Fu, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Ming-Chau Chang, Wei-Ming Chen
Summary: This study explored the potential of revitalizing human decellularized allogeneic bone with human mesenchymal stem cells for osteochondral regeneration. Results showed that bone marrow and adipose tissue-derived MSCs exhibited higher osteogenic potential, while Wharton's jelly-derived MSCs had higher chondrogenic potential. Chondrogenic MSCs-seeded allogeneic bone may serve as potential osteochondral constructs for regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Clark T. Hung, Jennifer Racine-Avila, Matthew J. Pellicore, Roy Aaron
Summary: The skeleton has the ability to remodel and repair itself in response to biophysical stimuli, allowing it to adapt to its physiological roles. Cells in the skeleton sense and respond to these stimuli to meet the demands of the organism. Mechanical strain is the most recognized stimulus, but other signals such as fluid flow and ion movements also play a role. The application of electrical and electromagnetic fields can be used to study the effects of these stimuli on cell differentiation and extracellular matrix formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Marcela Angelica De la Fuente-Hernandez, Miguel Angel Sarabia-Sanchez, Jorge Melendez-Zajgla, Vilma Maldonado-Lagunas
Summary: In recent years, it has been recognized that long noncoding RNAs (lncRNAs) play a crucial role in cell differentiation processes, particularly in adipogenesis, chondrogenesis, myogenesis, and osteogenesis. Understanding the role of lncRNAs in the signaling network involved in these differentiation processes helps to elucidate the mechanisms of cell differentiation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marta Carnovali, Giuseppe Banfi, Giovanni Porta, Massimo Mariotti
Summary: Foods can modulate inflammation and skeletal development, and the intestine plays a key role in bone health regulation. Soybean meal can induce intestinal inflammation in zebrafish, which affects different mechanisms of bone development in different zones of the skeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zhujun Yang, Xuejian Li, Xueqi Gan, Mengying Wei, Chunbao Wang, Guodong Yang, Yimin Zhao, Zhuoli Zhu, Zhongshan Wang
Summary: Engineered exosomes containing Bmp2 mRNA were successfully enriched and loaded into a hydrogel for sustained release, leading to more efficient and safe bone regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Cell Biology
Graziana Monaco, Yann D. Ladner, Alicia J. El Haj, Nicholas R. Forsyth, Mauro Alini, Martin J. Stoddart
Summary: The study investigated the impact of different culture conditions on the differentiation of human bone marrow mesenchymal stromal cells (hBMSCs) towards cartilage and bone. The results showed that chondrogenic differentiation exhibited better performance compared to osteogenic differentiation under different culture conditions.
Review
Chemistry, Physical
Alessia Ricci, Amelia Cataldi, Susi Zara, Marialucia Gallorini
Summary: Graphene, with its exceptional physical properties, has found extensive applications in various fields such as antibacterial agents, photothermal therapy, and tissue engineering. Graphene oxide (GO), as the most adaptable derivate, has been widely used as a coating for scaffolds to enhance bone and chondrogenic regeneration, and has shown promising immunomodulatory properties.
Review
Chemistry, Medicinal
Madhan Jeyaraman, Sathish Muthu, Prakash Gangadaran, Rajni Ranjan, Naveen Jeyaraman, Gollahalli Shivashankar Prajwal, Prabhu Chandra Mishra, Ramya Lakshmi Rajendran, Byeong-Cheol Ahn
Summary: The periosteum, rich in pluripotent stem cells, plays a crucial role in fracture healing and remodeling. While its potential in tissue engineering is recognized, further research is needed to explore the bone-forming capabilities of its stem cells.
Article
Nanoscience & Nanotechnology
Meenakshi Kamaraj, Uday Kiran Roopavath, Pravin Shankar Giri, Nandha Kumar Ponnusamy, Subha Narayan Rath
Summary: Osteochondral regeneration is a challenging problem in clinical situations due to the low regeneration ability of cartilage tissue and the dissimilar nature of bone and cartilage. This study successfully synthesized a single biomaterial using calcium-deficient apatite (CDA) with added manganese, which exhibited 3D printing ability, improved compressive strength, and biocompatibility. The concentrations of manganese in the CDA ceramic were found to influence the differentiation behavior of MSCs, making manganese-doped CDA a promising candidate for bone and cartilage regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell & Tissue Engineering
Rose Ann G. Franco, Eamonn McKenna, Pamela G. Robey, Ross W. Crawford, Michael R. Doran, Kathryn Futrega
Summary: For the use of bone marrow stromal cells (BMSC) in cartilage repair, controlling their hypertrophic differentiation is crucial. TGF-beta 1 stimulation triggers chondrogenic and hypertrophic differentiation in BMSCs, and silencing SP7, a transcription factor associated with hypertrophic differentiation, reduces both hypertrophic and chondrogenic differentiation processes. However, SP7 silencing compromises overall trilineage differentiation of BMSCs and makes it challenging to promote chondrogenesis while reducing hypertrophy in cartilage tissue engineering.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Gerard Boix-Lemonche, Richard M. Nagymihaly, Xhevat Lumi, Goran Petrovski
Summary: This research demonstrates the trilineage differentiation potential of human lens cells and reveals the risks of complications during cataract surgery, such as calcification and osteogenic differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Hisaya Kato, Yoshiro Maezawa, Naoya Takayama, Yasuo Ouchi, Hiyori Kaneko, Daisuke Kinoshita, Aki Takada-Watanabe, Motohiko Oshima, Masaya Koshizaka, Hideyuki Ogata, Yoshitaka Kubota, Nobuyuki Mitsukawa, Koji Eto, Atsushi Iwama, Koutaro Yokote
Summary: Werner syndrome (WS) is characterized by accelerated aging symptoms in the limbs, with distinct gene expression and differentiation capabilities observed in fibroblasts from the feet compared to the trunk, which may partially explain the underlying mechanism behind this disease phenotype.
Article
Developmental Biology
Azim Pothiawala, Berke E. Sahbazoglu, Bryan K. Ang, Nadine Matthias, Guangsheng Pei, Qing Yan, Brian R. Davis, Johnny Huard, Zhongming Zhao, Naoki Nakayama
Summary: It has been discovered that mesodermal progeny of human pluripotent stem cells can differentiate into two types of chondrogenic mesenchymal cells with distinct characteristics and functions. GDF5(+) cells can generate tissue similar to permanent cartilage, while SOX9(+) cells resemble neural crest-like progeny. These findings shed light on the cellular differentiation and molecular regulation mechanisms during cartilage development.
Article
Multidisciplinary Sciences
Karol Nowosad, Rutger W. W. Brouwer, Adrian Odrzywolski, Anne L. Korporaal, Bartlomiej Gielniewski, Bartosz Wojtas, Wilfred F. J. van IJcken, Frank Grosveld, Danny Huylebroeck, Przemko Tylzanowski
Summary: This study utilizes ChIP-sequencing to map specific regulatory elements related to the formation and diseases of the synovial joint and adjacent phalange. The findings provide valuable insights into the transcriptional control of joint development and serve as a resource for identifying potential disease-causing genomic regions.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
A. Gigout, H. Guehring, D. Froemel, A. Meurer, C. Ladel, D. Reker, A. C. Bay-Jensen, M. A. Karsdal, S. Lindemann
OSTEOARTHRITIS AND CARTILAGE
(2017)
Article
Chemistry, Medicinal
Ulrich Graedler, Paul Czodrowski, Christos Tsaklakidis, Markus Klein, Daniela Werkmann, Sven Lindemann, Klaus Maskos, Birgitta Leuthner
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Article
Neurosciences
Nicola Palomero-Gallagher, Axel Schleicher, Sven Lindemann, Alina Lessenich, Karl Zilles, Wolfgang Loescher
EXPERIMENTAL NEUROLOGY
(2008)
Correction
Psychology, Biological
Sven Lindemann, Manuela Gernert, Mustapha Bennay, Michael Koch, Wolfgang Loescher
PHYSIOLOGY & BEHAVIOR
(2008)
Article
Orthopedics
Sylvia Mueller, Sven Lindemann, Anne Gigout
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Orthopedics
N. Sharma, P. Drobinski, A. Kayed, Z. Chen, C. F. Kjelgaard-Petersen, T. Gantzel, M. A. Karsdal, M. Michaelis, C. Ladel, A. C. Bay-Jensen, S. Lindemann, C. S. Thudium
OSTEOARTHRITIS AND CARTILAGE
(2020)
Article
Biochemistry & Molecular Biology
Tanja Mang, Sven Lindemann, Anne Gigout
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Tanja Mang, Kerstin Kleinschmidt-Doerr, Frank Ploeger, Sven Lindemann, Anne Gigout
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Anne Sofie Siebuhr, Daniela Werkmann, Anne-C Bay-Jensen, Christian S. Thudium, Morten Asser Karsdal, Benedikte Serruys, Christoph Ladel, Martin Michaelis, Sven Lindemann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Susanne Mueller, Suzanne Ackloo, Arij Al Chawaf, Bissan Al-Lazikani, Albert Antolin, Jonathan B. Baell, Hartmut Beck, Shaunna Beedie, Ulrich A. K. Betz, Gustavo Arruda Bezerra, Paul E. Brennan, David Brown, Peter J. Brown, Alex N. Bullock, Adrian J. Carter, Apirat Chaikuad, Mathilde Chaineau, Alessio Ciulli, Ian Collins, Jan Dreher, David Drewry, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Stephen Frye, Stephen M. Fuchs, Matthew D. Hall, Ingo Hartung, Alexander Hillisch, Stephen H. Hitchcock, Evert Homan, Natarajan Kannan, James R. Kiefer, Stefan Knapp, Milka Kostic, Stefan Kubicek, Andrew R. Leach, Sven Lindemann, Brian D. Marsden, Hisanori Matsui, Jordan L. Meier, Daniel Merk, Maurice Michel, Maxwell R. Morgan, Anke Mueller-Fahrnow, Dafydd R. Owen, Benjamin G. Perry, Saul H. Rosenberg, Kumar Singh Saikatendu, Matthieu Schapira, Cora Scholten, Sujata Sharma, Anton Simeonov, Michael Sundstrom, Giulio Superti-Furga, Matthew H. Todd, Claudia Tredup, Masoud Vedadi, Frank von Delft, Timothy M. Willson, Georg E. Winter, Paul Workman, Cheryl H. Arrowsmith
Summary: Twenty years after the first draft of the human genome was published, our understanding of the human proteome is still incomplete. The majority of proteins in the human proteome remain uncharacterized, with only a small percentage successfully targeted for drug discovery. Target 2035 aims to bridge this gap by developing new technologies for the entire human proteome by 2035.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Rheumatology
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim
Summary: The study found that oxidant production and chondrocyte hypertrophy occur very early in the onset of OA in rat models, possibly initiating the pathogenic events of OA.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Stefan Sieber, Martin Michaelis, Hans Guehring, Sven Lindemann, Anne Gigout
BIORESEARCH OPEN ACCESS
(2020)
Article
Neurosciences
Marko Schirmer, Alexander Kaiser, Alina Lessenich, Sven Lindemann, Maren Fedrowitz, Manuela Gernert, Wolfgang Loescher
Article
Behavioral Sciences
Marko Schirmer, Alina Lessenich, Sven Lindemann, Wolfgang Loescher
BEHAVIOURAL BRAIN RESEARCH
(2007)