Effects of Sprifermin, IGF1, IGF2, BMP7, or CNP on Bovine Chondrocytes in Monolayer and 3D Culture

Intra-articular treatment options for knee osteoarthritis

(2018) Ian A. Jones et al.   Nature Reviews Rheumatology

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix

(2017) A. Gigout et al.   OSTEOARTHRITIS AND CARTILAGE

­­­­­Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis

(2015) Tomoya Uchimura et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

(2014) M Cucchiarini et al.   GENE THERAPY

Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function

(2014) N.J. Peake et al.   OSTEOARTHRITIS AND CARTILAGE

Targeted Delivery to Cartilage Is Critical for In Vivo Efficacy of Insulin-like Growth Factor 1 in a Rat Model of Osteoarthritis

(2014) Francesco S. Loffredo et al.   Arthritis & Rheumatology

Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

(2014) L. Stefan Lohmander et al.   Arthritis & Rheumatology

Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7

(2013) M.M.J. Caron et al.   OSTEOARTHRITIS AND CARTILAGE

Protective Effects of C-Type Natriuretic Peptide on Linear Growth and Articular Cartilage Integrity in a Mouse Model of Inflammatory Arthritis

(2013) Hülya Bükülmez et al.   Arthritis & Rheumatology

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

The Role of Growth Factors in Cartilage Repair

(2011) Lisa A. Fortier et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer

(2011) Shuiliang Shi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

Effects of Low Concentration BMP-7 on Human Osteoarthritic Chondrocytes: Comparison of Different Applications

(2010) Karsten Gavenis et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Effects induced by BMPS in cultures of human articular chondrocytes: Comparative studies

(2008) Susan Chubinskaya et al.   GROWTH FACTORS

Differential Effects of Natriuretic Peptide Stimulation on Tissue-Engineered Cartilage

(2008) Stephen D. Waldman et al.   TISSUE ENGINEERING PART A

Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression

(2008) Masaya Hayashi et al.   ARTHRITIS RESEARCH & THERAPY