Mitochondrial reactive oxygen species cause major oxidative mitochondrial DNA damages and repair pathways

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

(2019) Leif S. Ludwig et al.   CELL

Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

(2018) Orrette R Wauchope et al.   NUCLEIC ACIDS RESEARCH

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin

(2018) Paula I. Moreira   JOURNAL OF ALZHEIMERS DISEASE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Mitochondrial DNA synthesis fuels NLRP3 inflammasome

(2018) Rebecca C. Coll et al.   CELL RESEARCH

Accurate identification of single-nucleotide variants in whole-genome-amplified single cells

(2017) Xiao Dong et al.   NATURE METHODS

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of mitochondrial sirtuins in health and disease

(2016) Brenna Osborne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair

(2016) Hoi-Man Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells

(2016) Gayle M. Gordillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects

(2016) Elena Gammella et al.   Oxidative Medicine and Cellular Longevity

Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase

(2016) Aishwarya Prakash et al.   PLoS One

Simultaneous determination of 8-oxo-2’-deoxyguanosine and 8-oxo-2’-deoxyadenosine in human retinal DNA by liquid chromatography nanoelectrospray-tandem mass spectrometry

(2016) Bin Ma et al.   Scientific Reports

Mitochondrial proteases and protein quality control in ageing and longevity

(2015) Marie-Paule Hamon et al.   AGEING RESEARCH REVIEWS

Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

(2015) Kamel Mohammedi et al.   Cardiovascular Diabetology

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome

(2015) Orrette R. Wauchope et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rethinking transcription coupled DNA repair

(2015) Venu Kamarthapu et al.   CURRENT OPINION IN MICROBIOLOGY

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species

(2015) MOTOYA TANAKA et al.   ONCOLOGY REPORTS

The role of thioredoxin reductase 1 in melanoma metabolism and metastasis

(2015) Pamela B. Cassidy et al.   Pigment Cell & Melanoma Research

Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species

(2015) Ryan J. Mailloux   Redox Biology

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

(2014) Daniel T. Shaughnessy et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Formation and repair of oxidative damage in the mitochondrial DNA

(2014) Meltem Muftuoglu et al.   MITOCHONDRION

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

(2014) Bartosz Szczesny et al.   NUCLEIC ACIDS RESEARCH

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

(2014) Thomas A. Guilliam et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

(2014) Chi Kwan Tsang et al.   Nature Communications

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

(2013) Simran S. Sabharwal et al.   BIOCHEMICAL JOURNAL

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer

(2013) Krzysztof Roszkowski et al.   MEDICAL SCIENCE MONITOR

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Oxidatively induced DNA damage: Mechanisms, repair and disease

(2012) Miral Dizdaroglu   CANCER LETTERS

Oxidative Stress and Altered Mitochondrial Function in Neurodegenerative Diseases: Lessons From Mouse Models

(2012) J.C. Fernandez-Checa et al.   CNS & Neurological Disorders-Drug Targets

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Overexpression of DNA Polymerase Zeta Reduces the Mitochondrial Mutability Caused by Pathological Mutations in DNA Polymerase Gamma in Yeast

(2012) Enrico Baruffini et al.   PLoS One

The dynamic regulation of NAD metabolism in mitochondria

(2012) Liana Roberts Stein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ Mice

(2011) Dong Kyun Woo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

(2011) Lokendra Kumar Sharma et al.   HUMAN MOLECULAR GENETICS

Repair of persistent strand breaks in the mitochondrial genome

(2011) Peter Sykora et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Genetic insights into OXPHOS defect and its role in cancer

(2010) Dhyan Chandra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

(2010) A Lemarie et al.   CELL DEATH AND DIFFERENTIATION

Ultrasensitive Simultaneous Quantification of 1,N2-Etheno-2′-deoxyguanosine and 1,N2-Propano-2′-deoxyguanosine in DNA by an Online Liquid Chromatography−Electrospray Tandem Mass Spectrometry Assay

(2010) Camila C. M. Garcia et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

(2010) Maria D. Aamann et al.   FASEB JOURNAL

Oxidatively generated base damage to cellular DNA

(2010) Jean Cadet et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

(2010) York Kamenisch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondria and aging

(2010) Tomas A. Prolla et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Role of Sirtuins in the Control of Metabolic Homeostasis

(2009) Jiujiu Yu et al.   Annals of the New York Academy of Sciences

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of the mitochondrial permeability transition pore in heart disease

(2009) Andrew P. Halestrap et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Mitochondria in the human heart

(2009) H. Lemieux et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

DNA Damage and Repair: From Molecular Mechanisms to Health Implications

(2008) Fabio Altieri et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

(2008) Mansour Akbari et al.   DNA REPAIR

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING