Apamin Suppresses LPS-Induced Neuroinflammatory Responses by Regulating SK Channels and TLR4-Mediated Signaling Pathways

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

(2020) Ha Thi Thu Do et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway

(2020) Chung-I Yu et al.   NEUROTOXICITY RESEARCH

Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease

(2020) Hyemin Gu et al.   Toxins

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

(2019) Ka-Young Ryu et al.   Journal of Neuroinflammation

Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson’s disease and cell culture via inactivating TLR4/NF-κB pathway

(2018) Fang-Xue Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways

(2018) Jialin Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Efficacy of Combined Treatment with Acupuncture and Bee Venom Acupuncture as an Adjunctive Treatment for Parkinson's Disease

(2018) Seung-Yeon Cho et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

(2018) Hye Yeon Nam et al.   Journal of Neuroinflammation

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

(2018) Ju-Young Lee et al.   Journal of Neuroinflammation

Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

(2018) Soraya Wilke Saliba et al.   Journal of Neuroinflammation

High-intensity intermittent exercise increases adenosine hydrolysis in platelets and lymphocytes and promotes platelet aggregation in futsal athletes

(2018) Vanessa Valéria Miron et al.   PLATELETS

Apamin suppresses biliary fibrosis and activation of hepatic stellate cells

(2017) Jung-Yeon Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

(2017) Jin Han Nam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TGF-β1 Neuroprotection via Inhibition of Microglial Activation in a Rat Model of Parkinson’s Disease

(2017) Xiao Chen et al.   Journal of Neuroimmune Pharmacology

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway

(2017) Ji-Hyun Park et al.   Journal of Neuroinflammation

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

(2017) Nicholas C. Woodward et al.   Journal of Neuroinflammation

Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

(2017) K Kondo et al.   LEUKEMIA

Deep hypothermia therapy attenuates LPS-induced microglia neuroinflammation via the STAT3 pathway

(2017) G. Tong et al.   NEUROSCIENCE

Apamin inhibits TNF-α- and IFN-γ-induced inflammatory cytokines and chemokines via suppressions of NF-κB signaling pathway and STAT in human keratinocytes

(2017) Woon-Hae Kim et al.   Pharmacological Reports

6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ

(2017) Qinghe Han et al.   Oncotarget

Pinus densiflora needle supercritical fluid extract suppresses the expression of pro-inflammatory mediators iNOS, IL-6 and IL-1β, and activation of inflammatory STAT1 and STAT3 signaling proteins in bacterial lipopolysaccharide-challenged murine macrophages

(2017) Thamizhiniyan Venkatesan et al.   DARU-Journal of Pharmaceutical Sciences

Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor κB activation via Akt, ERK, and JNK in LPS-stimulated microglial cells

(2015) Dong-Kyung Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Angiotensin Receptor Blockade Modulates NFκB and STAT3 Signaling and Inhibits Glial Activation and Neuroinflammation Better than Angiotensin-Converting Enzyme Inhibition

(2015) Shahnawaz Ali Bhat et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis

(2015) Wagdy K.B. Khalil et al.   NEUROCHEMISTRY INTERNATIONAL

Apamin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppressions of activated Akt and Erk signaling pathway

(2015) Jung-Yeon Kim et al.   VASCULAR PHARMACOLOGY

The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases

(2015) Woo-Ram Lee et al.   Toxins

Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan

(2015) Miguel Moreno et al.   Toxins

IL1-β expression in multiple sclerosis

(2014) Amir Hadi Maghzi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

(2013) Daniel Alvarez-Fischer et al.   PLoS One

Association of IL1A and IL1B loci with primary open angle glaucoma

(2012) Suddhasil Mookherjee et al.   BMC Medical Genetics

The Protective Effect of Apamin on LPS/Fat-Induced Atherosclerotic Mice

(2012) Soo-Jung Kim et al.   Evidence-based Complementary and Alternative Medicine

Apamin inhibits THP-1-derived macrophage apoptosis via mitochondria-related apoptotic pathway

(2012) Soo-Jung Kim et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Protective Roles for Potassium SK/KCa2 Channels in Microglia and Neurons

(2012) Amalia M. Dolga et al.   Frontiers in Pharmacology

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

(2010) Lyanne C Schlichter et al.   Journal of Neuroinflammation

Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and NF-κB-dependent mechanisms

(2009) Hyun-Ji Cho et al.   JOURNAL OF ETHNOPHARMACOLOGY

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

(2008) X. Liu et al.   BLOOD

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN