DNA methylation in human sperm: a systematic review

Methylation levels of IGF2 and KCNQ1 in spermatozoa from infertile men are associated with sperm DNA damage

(2019) Wuhua Ni et al.   ANDROLOGIA

Investigating the relationship between BRCA1 and BRCA2 genes methylation profile and sperm DNA fragmentation in infertile men

(2019) Emel Kabartan et al.   ANDROLOGIA

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

(2019) Georgina Mansell et al.   BMC GENOMICS

pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS)

(2019) Stefan Graw et al.   BMC BIOINFORMATICS

Male obesity effects on sperm and next-generation cord blood DNA methylation

(2019) Ramya Potabattula et al.   PLoS One

Correlation of Internal Exposure Levels of Polycyclic Aromatic Hydrocarbons to Methylation of Imprinting Genes of Sperm DNA

(2019) Yufeng Ma et al.   International Journal of Environmental Research and Public Health

Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism

(2019) Donovan Chan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impact of cigarette-smoking on sperm DNA methylation and its effect on sperm parameters

(2018) Y. Alkhaled et al.   ANDROLOGIA

Effects of doxorubicin on sperm DNA methylation in mouse models of testicular toxicity

(2018) Kazuya Sakai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time

(2018) Marie Forest et al.   Epigenetics

The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis

(2018) Nan B Oldereid et al.   HUMAN REPRODUCTION UPDATE

Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults

(2018) J. Richard Pilsner et al.   REPRODUCTIVE TOXICOLOGY

Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

(2018) Lars R. Ingerslev et al.   Clinical Epigenetics

Environmental Toxins and Male Fertility

(2018) Mahmoud Mima et al.   Current Urology Reports

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice

(2018) Adam J. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposure to childhood abuse is associated with human sperm DNA methylation

(2018) Andrea L. Roberts et al.   Translational Psychiatry

Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: a randomized controlled trial

(2018) Albert Salas-Huetos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Oxidative stress-induced alterations in seminal plasma antioxidants: Is there any association with keap1 gene methylation in human spermatozoa?

(2018) Mahsa Darbandi et al.   ANDROLOGIA

Paternal germ line aging: DNA methylation age prediction from human sperm

(2018) Timothy G. Jenkins et al.   BMC GENOMICS

Cannabinoid exposure and altered DNA methylation in rat and human sperm

(2018) Susan K. Murphy et al.   Epigenetics

Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss

(2018) Philip Spinelli et al.   HUMAN MOLECULAR GENETICS

Genome-wide differential methylation analyses identifies methylation signatures of male infertility

(2018) Kumar Mohanty Sujit et al.   HUMAN REPRODUCTION

Reactive oxygen species-induced alterations in H19-Igf2 methylation patterns, seminal plasma metabolites, and semen quality

(2018) Mahsa Darbandi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The status of global DNA methylation in the spermatozoa of smokers and non-smokers

(2018) Mohammed F. Hamad et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Identification of 55,000 Replicated DNA Methylation QTL

(2018) Allan F. McRae et al.   Scientific Reports

Sperm imprinting integrity in seminoma patients?

(2018) Céline Bruno et al.   Clinical Epigenetics

Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study

(2018) Qiuqin Tang et al.   Clinical Epigenetics

Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: A pilot study

(2018) Meiping Tian et al.   CHEMOSPHERE

Estimation of a significance threshold for epigenome-wide association studies

(2017) Ayden Saffari et al.   GENETIC EPIDEMIOLOGY

Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability

(2017) Kei Fukuda et al.   HUMAN MOLECULAR GENETICS

Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study

(2017) Haotian Wu et al.   HUMAN REPRODUCTION

Alterations in the sperm histone-retained epigenome are associated with unexplained male factor infertility and poor blastocyst development in donor oocyte IVF cycles

(2017) Michelle M Denomme et al.   HUMAN REPRODUCTION

Aberrations in sperm DNA methylation patterns are associated with abnormalities in semen parameters of subfertile males

(2017) Mohammed Laqqan et al.   Reproductive Biology

Alterations in sperm DNA methylation patterns of oligospermic males

(2017) Mohammed Laqqan et al.   Reproductive Biology

Aberrant DNA methylation patterns of human spermatozoa in current smoker males

(2017) M. Laqqan et al.   REPRODUCTIVE TOXICOLOGY

Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis

(2017) Yu-Sheng Cheng et al.   UROLOGY

What the human sperm methylome tells us

(2017) Cristina Camprubí et al.   Epigenomics

DNA methylation imprinting errors in spermatogenic cells from maturation arrest azoospermic patients

(2017) P. I. Marques et al.   Andrology

Cigarette smoking significantly alters sperm DNA methylation patterns

(2017) T. G. Jenkins et al.   Andrology

Spermatozoa from males with reduced fecundity exhibit differential DNA methylation patterns

(2017) M. Laqqan et al.   Andrology

Differential DNA Methylation Regions in Adult Human Sperm following Adolescent Chemotherapy: Potential for Epigenetic Inheritance

(2017) Margarett Shnorhavorian et al.   PLoS One

Common and distinct structural features of schizophrenia and bipolar disorder: The European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT) study

(2017) Eleonora Maggioni et al.   PLoS One

Factors associated with aberrant imprint methylation and oligozoospermia

(2017) Norio Kobayashi et al.   Scientific Reports

Paternal age and psychiatric disorders: A review

(2016) Hilde de Kluiver et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

DNA methylation levels of imprinted and nonimprinted genes DMRs associated with defective human spermatozoa

(2016) J. Xu et al.   ANDROLOGIA

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Exposure to persistent organic pollutants and sperm DNA methylation changes in Arctic and European populations

(2016) Claudia Consales et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Cigarette Smoking and Semen Quality: A New Meta-analysis Examining the Effect of the 2010 World Health Organization Laboratory Methods for the Examination of Human Semen

(2016) Reecha Sharma et al.   EUROPEAN UROLOGY

Highly conserved epigenetic regulation of BOULE and DAZL is associated with human fertility

(2016) Chenwang Zhang et al.   FASEB JOURNAL

Alterations of testis-specific promoter methylation in cell-free seminal deoxyribonucleic acid of idiopathic nonobstructive azoospermic men with different testicular phenotypes

(2016) Chunlin Wu et al.   FERTILITY AND STERILITY

Decreased fecundity and sperm DNA methylation patterns

(2016) Timothy G. Jenkins et al.   FERTILITY AND STERILITY

Stability of the human sperm DNA methylome to folic acid fortification and short-term supplementation

(2016) D. Chan et al.   HUMAN REPRODUCTION

Epigenome-wide association study of body mass index and the adverse outcomes of adiposity

(2016) Simone Wahl et al.   NATURE

Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations

(2016) Jacob Gratten et al.   NATURE GENETICS

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Sperm Chromatin Immaturity Observed in Short Abstinence Ejaculates Affects DNA Integrity and Longevity In Vitro

(2016) Shubhashree Uppangala et al.   PLoS One

Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis

(2016) Cristina Camprubí et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Abnormal Methylation of Imprinted Genes and Cigarette Smoking

(2016) Hao Dong et al.   Reproductive Sciences

Epigenetics of the myotonic dystrophy-associatedDMPKgene neighborhood

(2016) Lauren Buckley et al.   Epigenomics

Evaluation of DNA methylation at imprinted DMRs in the spermatozoa of oligozoospermic men in association withMTHFRC677T genotype

(2016) K. Louie et al.   Andrology

Intra- and inter-individual differences in human sperm DNA methylation

(2016) E. Dere et al.   Andrology

Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures

(2016) T. G. Jenkins et al.   Andrology

Different Levels of DNA Methylation Detected in Human Sperms after Morphological Selection Using High Magnification Microscopy

(2016) Nino Guy Cassuto et al.   Biomed Research International

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study

(2016) Adelheid Soubry et al.   Clinical Epigenetics

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

The Expression of Cysteine-Rich Secretory Protein 2 (CRISP2) and Its Specific Regulator miR-27b in the Spermatozoa of Patients with Asthenozoospermia1

(2015) Jun-Hao Zhou et al.   BIOLOGY OF REPRODUCTION

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes

(2015) Eilis Hannon et al.   Epigenetics

Histone methylation and acetylation in ejaculated human sperm: effects of swim-up and smoking

(2015) Seul Ki Kim et al.   FERTILITY AND STERILITY

Aberrant sperm DNA methylation predicts male fertility status and embryo quality

(2015) Kenneth I. Aston et al.   FERTILITY AND STERILITY

High-dose folic acid supplementation alters the human sperm methylome and is influenced by theMTHFRC677T polymorphism

(2015) Mahmoud Aarabi et al.   HUMAN MOLECULAR GENETICS

Promoter targeted bisulfite sequencing reveals DNA methylation profiles associated with low sperm motility in asthenozoospermia

(2015) Ye Du et al.   HUMAN REPRODUCTION

Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility

(2015) Rocío G. Urdinguio et al.   HUMAN REPRODUCTION

Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort

(2015) Jason I Feinberg et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation

(2015) Pei-Chien Tsai et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Epigenomics, gestational programming and risk of metabolic syndrome

(2015) M Desai et al.   INTERNATIONAL JOURNAL OF OBESITY

Removing unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data

(2015) Jovana Maksimovic et al.   NUCLEIC ACIDS RESEARCH

DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele

(2015) Mahsa Bahreinian et al.   Systems Biology in Reproductive Medicine

Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans

(2015) Joshua Denham et al.   Epigenomics

Sperm global DNA methylation level: association with semen parameters and genome integrity

(2015) D. Montjean et al.   Andrology

Epigenetic heterogeneity of developmentally important genes in human sperm: Implications for assisted reproduction outcome

(2015) Juliane Kuhtz et al.   Epigenetics

Epigenetic Alterations in Density Selected Human Spermatozoa for Assisted Reproduction

(2015) Bolan Yu et al.   PLoS One

Tissue-specific DNA methylation profiles regulate liver-specific expression of the APOA1/C3/A4/A5 cluster and can be manipulated with demethylating agents on intestinal cells

(2014) Montse Guardiola et al.   ATHEROSCLEROSIS

The Noninvasive Detection of RARβ2 Promoter Methylation for the Diagnosis of Prostate Cancer

(2014) Tong Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Exposure to Perfluoroalkyl Substances and Sperm DNA Global Methylation in Arctic and European Populations

(2014) Giorgio Leter et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Fundamental diversity of human CpG islands at multiple biological levels

(2014) Jia Zeng et al.   Epigenetics

Epigenetic germline mosaicism in infertile men

(2014) Sandra Laurentino et al.   HUMAN MOLECULAR GENETICS

Indices of methylation in sperm DNA from fertile men differ between distinct geographical regions

(2014) C. Consales et al.   HUMAN REPRODUCTION

Intra-sample heterogeneity of sperm DNA methylation

(2014) Timothy G. Jenkins et al.   MOLECULAR HUMAN REPRODUCTION

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

(2014) Yanchang Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility

(2014) Timothy G. Jenkins et al.   PLoS Genetics

Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA Hypomethylation

(2013) Robert Kim et al.   BMC CANCER

A data-driven approach to preprocessing Illumina 450K methylation array data

(2013) Ruth Pidsley et al.   BMC GENOMICS

Methylation loss atH19imprinted gene correlates withmethylenetetrahydrofolate reductasegene promoter hypermethylation in semen samples from infertile males

(2013) John C Rotondo et al.   Epigenetics

Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels

(2013) Timothy G. Jenkins et al.   FERTILITY AND STERILITY

Methylation changes in mature sperm deoxyribonucleic acid from oligozoospermic men: assessment of genetic variants and assisted reproductive technology outcome

(2013) Debbie Montjean et al.   FERTILITY AND STERILITY

Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility

(2013) Marcy E. Richardson et al.   HUMAN MOLECULAR GENETICS

Lack of association of MTHFR rs1801133 polymorphism and CTCFL mutations with sperm methylation errors in infertile patients

(2013) Cristina Camprubí et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Effect of temozolomide on male gametes: an epigenetic risk to the offspring?

(2013) I. Berthaut et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

Methylation pattern of methylene tetrahydrofolate reductase and small nuclear ribonucleoprotein polypeptide N promoters in oligoasthenospermia: a case-control study

(2013) Anca Botezatu et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Fertility (update): summary of NICE guidance

(2013) E. Fields et al.   BMJ-British Medical Journal

LINE-1 hypomethylation in spermatozoa is associated with Bisphenol A exposure

(2013) M. Miao et al.   Andrology

DNA methylation in spermatozoa as a prospective marker in andrology

(2013) R. Kläver et al.   Andrology

Broad DNA methylation changes of spermatogenesis, inflammation and immune response-related genes in a subgroup of sperm samples for assisted reproduction

(2013) B. Schütte et al.   Andrology

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Analysis of the global methylation status of human spermatozoa and its association with the tendency of these cells to enter apoptosis

(2012) J. Barzideh et al.   ANDROLOGIA

Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques

(2012) Cristina Camprubí et al.   Epigenetics

Methylation analysis of idiopathic recurrent spontaneous miscarriage cases reveals aberrant imprinting at H19 ICR in normozoospermic individuals

(2012) Mandar Ankolkar et al.   FERTILITY AND STERILITY

Definitions of infertility and recurrent pregnancy loss: a committee opinion

(2012)   FERTILITY AND STERILITY

Methylation profile of the promoters of Nanog and Oct4 in ICSI human embryos

(2012) M. Al-Khtib et al.   HUMAN REPRODUCTION

Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion

(2012) J.C. Rotondo et al.   HUMAN REPRODUCTION

Routine cryopreservation of spermatozoa is safe — Evidence from the DNA methylation pattern of nine spermatozoa genes

(2012) Ruth Kläver et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Understanding transgenerational epigenetic inheritance via the gametes in mammals

(2012) Lucia Daxinger et al.   NATURE REVIEWS GENETICS

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

(2012) Jian Li et al.   PLoS Genetics

Analysis of the methylation pattern of six gene promoters in sperm of men with abnormal protamination

(2011) Laszlo Nanassy et al.   ASIAN JOURNAL OF ANDROLOGY

Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates

(2011) Antoine Molaro et al.   CELL

NANOG promoter methylation and expression correlation during normal and malignant human germ cell development

(2011) Daniel Nettersheim et al.   Epigenetics

Analysis of H19 methylation in control and abnormal human embryos, sperm and oocytes

(2011) Samira Ibala-Romdhane et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Abnormal methylation of the promoter of CREM is broadly associated with male factor infertility and poor sperm quality but is improved in sperm selected by density gradient centrifugation

(2011) Laszlo Nanassy et al.   FERTILITY AND STERILITY

Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis

(2011) Kenneth I. Aston et al.   FERTILITY AND STERILITY

A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder

(2011) Z Kaminsky et al.   MOLECULAR PSYCHIATRY

Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm

(2011) Sara E. Pacheco et al.   PLoS One

Aberrant DNA methylation at imprinted genes in testicular sperm retrieved from men with obstructive azoospermia and undergoing vasectomy reversal

(2011) Agata Minor et al.   REPRODUCTION

Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males

(2011) N. El Hajj et al.   Sexual Development

Mammalian Genomic Imprinting

(2011) M. S. Bartolomei et al.   Cold Spring Harbor Perspectives in Biology

Correction: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

(2011) Jordana T Bell et al.   GENOME BIOLOGY

Alu elements: know the SINEs

(2011) Prescott Deininger   GENOME BIOLOGY

Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis

(2010) Akiko Sato et al.   FERTILITY AND STERILITY

Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm†

(2010) Paulo Navarro-Costa et al.   HUMAN REPRODUCTION

Tackling the widespread and critical impact of batch effects in high-throughput data

(2010) Jeffrey T. Leek et al.   NATURE REVIEWS GENETICS

Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR)

(2010) Wei Wu et al.   PLoS One

CpG island methylation pattern in different human tissues and its correlation with gene expression

(2009) Shicai Fan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men

(2009) Céline Chalas Boissonnas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm

(2009) Hisato Kobayashi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Methylation defects of imprinted genes in human testicular spermatozoa

(2009) C. Joana Marques et al.   FERTILITY AND STERILITY

Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility

(2009) Saher Sue Hammoud et al.   FERTILITY AND STERILITY

Massive parallel bisulfite sequencing of CG-rich DNA fragments reveals that methylation of many X-chromosomal CpG islands in female blood DNA is incomplete

(2009) Michael Zeschnigk et al.   HUMAN MOLECULAR GENETICS

Oxidative DNA damage impairs global sperm DNA methylation in infertile men

(2009) Ozlem Tunc et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Human sperm chromatin stabilization: a proposed model including zinc bridges

(2009) L. Bjorndahl et al.   MOLECULAR HUMAN REPRODUCTION

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Influence of sperm chromatin anomalies on assisted reproductive technology outcome

(2008) Marzeyeh Tavalaee et al.   FERTILITY AND STERILITY

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

(2008) V. K. Rakyan et al.   GENOME RESEARCH

Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia

(2008) C.J. Marques et al.   MOLECULAR HUMAN REPRODUCTION