The role of gut microbiota in cancer treatment: friend or foe?

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer

(2019) Rogier Aäron Gaiser et al.   GUT

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

(2019) Chengcheng Jin et al.   CELL

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

(2019) Andrew Maltez Thomas et al.   NATURE MEDICINE

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

(2019) Jakob Wirbel et al.   NATURE MEDICINE

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

(2019) Yan Li et al.   Nature Communications

Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis

(2019) Yi-pin Lv et al.   Science Advances

A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer

(2019) Liyana Zaharuddin et al.   BMC GASTROENTEROLOGY

Microbiota and radiotherapy-induced gastrointestinal side-effects (MARS) study: a large pilot study of the microbiome in acute and late radiation enteropathy.

(2019) Miguel Reis Ferreira et al.   CLINICAL CANCER RESEARCH

Liver organoids: from basic research to therapeutic applications

(2019) Nicole Prior et al.   GUT

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

(2019) Shinichi Yachida et al.   NATURE MEDICINE

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

(2019) Vayu Maini Rekdal et al.   SCIENCE

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

(2019) Anthony T. Virtue et al.   Science Translational Medicine

Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy

(2019) Di-Wei Zheng et al.   Nature Biomedical Engineering

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

(2019) Erick Riquelme et al.   CELL

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

(2019) Hiroyuki Koike et al.   NATURE

The future of faecal transplants

(2019) Edward M. Giles et al.   NATURE REVIEWS MICROBIOLOGY

Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity

(2019) Xiaohang Long et al.   Nature Microbiology

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

(2019) Mireia Uribe-Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanotechnology intervention of the microbiome for cancer therapy

(2019) Wantong Song et al.   Nature Nanotechnology

Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver-Specific Microenvironment as a Drug Testing Platform

(2018) Yoonhee Jin et al.   ADVANCED FUNCTIONAL MATERIALS

Nivolumab versus docetaxel in previously treated advanced non-small-cell lung cancer (CheckMate 017 and CheckMate 057): 3-year update and outcomes in patients with liver metastases

(2018) E E Vokes et al.   ANNALS OF ONCOLOGY

Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer

(2018) L Derosa et al.   ANNALS OF ONCOLOGY

Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa

(2018) Sanjiv K. Hyoju et al.   ANNALS OF SURGERY

Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage

(2018) Jasper B. van Praagh et al.   ANNALS OF SURGERY

The Intestinal Microbiota in Colorectal Cancer

(2018) Herbert Tilg et al.   CANCER CELL

Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

(2018) Vrishketan Sethi et al.   GASTROENTEROLOGY

Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes

(2018) Geicho Nakatsu et al.   GASTROENTEROLOGY

Lactobacillus rhamnosusGG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells

(2018) Terrence E Riehl et al.   GUT

Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer

(2018) Il Ju Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan

(2018) Yung-Yu Hsieh et al.   Scientific Reports

Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives

(2018) Lijuan Sun et al.   Protein & Cell

Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers

(2018) Zhenwei Dai et al.   Microbiome

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

(2018) Jotham Suez et al.   CELL

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

(2018) Tsuyoshi Hamada et al.   Cancer Immunology Research

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer

(2018) Olabisi Oluwabukola Coker et al.   GUT

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

(2018) Yinghong Wang et al.   NATURE MEDICINE

Long term but not short term exposure to obesity related microbiota promotes host insulin resistance

(2018) Kevin P. Foley et al.   Nature Communications

Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy

(2018) Paolo A. Ascierto et al.   JAMA Oncology

Treatment Beyond Progression in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab in CheckMate 025

(2017) Bernard Escudier et al.   EUROPEAN UROLOGY

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice

(2017) Ho Tsoi et al.   GASTROENTEROLOGY

Novel insight into the role of microbiota in colorectal surgery

(2017) Radu Bachmann et al.   GUT

Long-term use of antibiotics and risk of colorectal adenoma

(2017) Yin Cao et al.   GUT

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Gut microbiota modulation of chemotherapy efficacy and toxicity

(2017) James L. Alexander et al.   Nature Reviews Gastroenterology & Hepatology

Anticancer effects of the microbiome and its products

(2017) Laurence Zitvogel et al.   NATURE REVIEWS MICROBIOLOGY

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

(2017) Leore T. Geller et al.   SCIENCE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Analysis ofFusobacteriumpersistence and antibiotic response in colorectal cancer

(2017) Susan Bullman et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Clinical significance of Fusobacterium nucleatum, epithelial–mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients

(2017) xuebing yan et al.   OncoTargets and Therapy

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

(2017) Arthur E. Frankel et al.   NEOPLASIA

Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma – A High Fusobacterial and Low Streptococcal Signature

(2017) Jae M. Shin et al.   Scientific Reports

Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc

(2016) Jawad Abed et al.   Cell Host & Microbe

Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis

(2016) Kensuke Yamamura et al.   CLINICAL CANCER RESEARCH

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

(2016) Sunny H Wong et al.   GUT

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

(2016) Romain Daillère et al.   IMMUNITY

Randomized Clinical Trial

(2016) Marcella Lobato D. Consoli et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

The gut microbiota and gastrointestinal surgery

(2016) Kristina Guyton et al.   Nature Reviews Gastroenterology & Hepatology

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

(2016) Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotic use and its consequences for the normal microbiome

(2016) Martin J. Blaser   SCIENCE

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

(2016) Krista Dubin et al.   Nature Communications

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

(2016) Alexandra E. Livanos et al.   Nature Microbiology

Mucosal adherent bacterial dysbiosis in patients with colorectal adenomas

(2016) Yingying Lu et al.   Scientific Reports

Prevention of irinotecan induced diarrhea by probiotics: A randomized double blind, placebo controlled pilot study

(2015) Michal Mego et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Recurrent antibiotic exposure may promote cancer formation – Another step in understanding the role of the human microbiota?

(2015) Ben Boursi et al.   EUROPEAN JOURNAL OF CANCER

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

(2015) Kosuke Mima et al.   GUT

Identification of an anti-inflammatory protein fromFaecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

(2015) E Quévrain et al.   GUT

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

(2015) Chamutal Gur et al.   IMMUNITY

Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice

(2015) Kirsty Brown et al.   ISME Journal

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

A catalog of the mouse gut metagenome

(2015) Liang Xiao et al.   NATURE BIOTECHNOLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Cancer and the microbiota

(2015) W. S. Garrett   SCIENCE

Gut mucosal microbiome across stages of colorectal carcinogenesis

(2015) Geicho Nakatsu et al.   Nature Communications

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma

(2014) T. Tahara et al.   CANCER RESEARCH

Probiotic VSL#3 Reduces Liver Disease Severity and Hospitalization in Patients With Cirrhosis: A Randomized, Controlled Trial

(2014) Radha K. Dhiman et al.   GASTROENTEROLOGY

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

(2014) Robert J Citorik et al.   NATURE BIOTECHNOLOGY

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

(2014) David Bikard et al.   NATURE BIOTECHNOLOGY

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Symbiotic lactobacilli stimulate gut epithelial proliferationviaNox-mediated generation of reactive oxygen species

(2013) Rheinallt M Jones et al.   EMBO JOURNAL

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

A metagenomic insight into our gut's microbiome

(2012) Patricia Lepage et al.   GUT

Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats

(2012) Hui-Lu Zhang et al.   JOURNAL OF HEPATOLOGY

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Biodiversity and functional genomics in the human microbiome

(2012) Xochitl C. Morgan et al.   TRENDS IN GENETICS

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

(2011) M. Castellarin et al.   GENOME RESEARCH

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients

(2010) S. Viaud et al.   CANCER RESEARCH

Fusobacterium nucleatum Outer Membrane Proteins Fap2 and RadD Induce Cell Death in Human Lymphocytes

(2010) C. W. Kaplan et al.   INFECTION AND IMMUNITY

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE