SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

(2019) Dario Nicetto et al.   SCIENCE

The pathological features of regulated necrosis

(2019) Wulf Tonnus et al.   JOURNAL OF PATHOLOGY

The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses

(2019) Véronique Adoue et al.   IMMUNITY

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

(2018) Masaki Kato et al.   Nature Communications

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

(2018) Manuel A. Rivas et al.   PLoS Genetics

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

Cellular Plasticity in Intestinal Homeostasis and Disease

(2018) Felipe de Sousa e Melo et al.   Cell Stem Cell

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

Emerging role of SETDB1 as a therapeutic target

(2017) Archana Venkataramana Karanth et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

­­­Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia­­

(2017) Trinna L. Cuellar et al.   JOURNAL OF CELL BIOLOGY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells

(2016) Alessandra Pasquarella et al.   DEVELOPMENT

Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease

(2016) Robert Häsler et al.   GUT

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

(2016) Rocío López-Posadas et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial calcineurin controls microbiota-dependent intestinal tumor development

(2016) Kenneth Peuker et al.   NATURE MEDICINE

Data-driven hypothesis weighting increases detection power in genome-scale multiple testing

(2016) Nikolaos Ignatiadis et al.   NATURE METHODS

Transcriptional landscape of repetitive elements in normal and cancer human cells

(2014) Steven W Criscione et al.   BMC GENOMICS

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

(2014) Tae-Hee Kim et al.   NATURE

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing

(2014) Pia V. Röder et al.   PLoS One

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

RNA-SeQC: RNA-seq metrics for quality control and process optimization

(2012) David S. DeLuca et al.   BIOINFORMATICS

Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations

(2012) Núria Planell et al.   GUT

A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

(2012) J. H. van Es et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

(2012) Sebastian Zeissig et al.   NATURE MEDICINE

Inflammation and Disruption of the Mucosal Architecture in Claudin-7–Deficient Mice

(2011) Lei Ding et al.   GASTROENTEROLOGY

Histology of plastic embedded amphibian embryos and larvae

(2011) Thomas Kurth et al.   GENESIS

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene

(2010) Amr M. Ghaleb et al.   DEVELOPMENTAL BIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The HP1α–CAF1–SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin

(2009) Alejandra Loyola et al.   EMBO REPORTS

Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and D-Cells in Mice

(2009) Diana Z. Ye et al.   GASTROENTEROLOGY

Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data

(2009) Jrgen Olsen et al.   INFLAMMATORY BOWEL DISEASES