Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets

The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant Staphylococcus aureus

(2019) Jeshina Janardhanan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

(2019) George A. Naclerio et al.   ChemMedChem

Permeability barriers of Gram-negative pathogens

(2019) Helen I. Zgurskaya et al.   Annals of the New York Academy of Sciences

Crossroads of Antibiotic Resistance and Biosynthesis

(2019) Timothy A. Wencewicz   JOURNAL OF MOLECULAR BIOLOGY

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

(2019) Wooseong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FtsZ as an Antibacterial Target: Status and Guidelines for Progressing This Avenue

(2019) Kennardy D. Kusuma et al.   ACS Infectious Diseases

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

(2019) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa

(2018) Gloria Andolina et al.   ACS Chemical Biology

A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria

(2018) Nicholas N. Nickerson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lipoprotein Transport: Greasing the Machines of Outer Membrane Biogenesis

(2018) Marcin Grabowicz   BIOESSAYS

Reconstitution of Staphylococcus aureus Lipoteichoic Acid Synthase Activity Identifies Congo Red as a Selective Inhibitor

(2018) Christopher R. Vickery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monoclonal antibody targeting the β-barrel assembly machine ofEscherichia coliis bactericidal

(2018) Kelly M. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

(2018) Ge Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunicamycin Mediated Inhibition of Wall Teichoic Acid Affects Staphylococcus aureus and Listeria monocytogenes Cell Morphology, Biofilm Formation and Virulence

(2018) Xingyue Zhu et al.   Frontiers in Microbiology

Understanding antibiotic resistance via outer membrane permeability

(2018) Ishan Ghai et al.   Infection and Drug Resistance

Optimized arylomycins are a new class of Gram-negative antibiotics

(2018) Peter A. Smith et al.   NATURE

Structural basis for dual-mode inhibition of the ABC transporter MsbA

(2018) Hoangdung Ho et al.   NATURE

A new class of synthetic retinoid antibiotics effective against bacterial persisters

(2018) Wooseong Kim et al.   NATURE

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters

(2018) Wooseong Kim et al.   ACS Infectious Diseases

Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation

(2018) David Sychantha et al.   Frontiers in Microbiology

Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli

(2018) Stefan U. Vetterli et al.   Science Advances

A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

(2017) Paramita Sarkar et al.   MedChemComm

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

(2017) Nathalie Heß et al.   Nature Communications

Wall teichoic acids mediate increased virulence in Staphylococcus aureus

(2017) Stefanie Wanner et al.   Nature Microbiology

Molecular mechanisms of membrane targeting antibiotics

(2016) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

(2016) Suguru Okuda et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

(2016) L. Vogeley et al.   SCIENCE

Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

(2016) Marlieke E. A. de Kraker et al.   PLOS MEDICINE

Persister formation in Staphylococcus aureus is associated with ATP depletion

(2016) Brian P. Conlon et al.   Nature Microbiology

Antimicrobial agents targeting bacterial cell walls and cell membranes

(2016) K. BUSH   REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES

TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and EnhancedIn VivoEfficacy against Methicillin-Resistant Staphylococcus aureus

(2015) Malvika Kaul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, syntheses and evaluation of 4-oxo-5-cyano thiouracils as SecA inhibitors

(2015) Arpana S. Chaudhary et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus

(2015) Jinshan Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Lantibiotic Nisin Induces Lipid II Aggregation, Causing Membrane Instability and Vesicle Budding

(2015) Katharina M. Scherer et al.   BIOPHYSICAL JOURNAL

Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors

(2015) Jianmei Cui et al.   ChemMedChem

The β-barrel membrane protein insertase machinery from Gram-negative bacteria

(2015) Nicholas Noinaj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Small-Molecule Inhibitors of Gram-Negative Lipoprotein Trafficking Discovered by Phenotypic Screening

(2015) Sarah M. McLeod et al.   JOURNAL OF BACTERIOLOGY

Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay

(2015) Asha S. Nayar et al.   JOURNAL OF BACTERIOLOGY

A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane inEscherichia coli

(2015) Matthias Urfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

Biosynthesis and Export of Bacterial Lipopolysaccharides

(2014) Chris Whitfield et al.   Annual Review of Biochemistry

Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria

(2014) Matthew G. Percy et al.   Annual Review of Microbiology

SecA-mediated targeting and translocation of secretory proteins

(2014) Katerina E. Chatzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Something old, something new: revisiting natural products in antibiotic drug discovery

(2014) Gerard D. Wright   CANADIAN JOURNAL OF MICROBIOLOGY

Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli

(2014) Dongchun Ni et al.   FASEB JOURNAL

Penicillin-binding protein 2a of methicillin-resistantStaphylococcus aureus

(2014) Jennifer Fishovitz et al.   IUBMB LIFE

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

(2014) Peter I. O’Daniel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Murgocil is a Highly Bioactive Staphylococcal-Specific Inhibitor of the Peptidoglycan Glycosyltransferase Enzyme MurG

(2013) Paul A. Mann et al.   ACS Chemical Biology

Wall Teichoic Acids of Gram-Positive Bacteria

(2013) Stephanie Brown et al.   Annual Review of Microbiology

An FtsZ-Targeting Prodrug with Oral Antistaphylococcal EfficacyIn Vivo

(2013) Malvika Kaul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli

(2013) David J. Sherman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria

(2013) Jessica L. Keffer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA

(2013) Courtney A. Barker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Structural insight into the biogenesis of β-barrel membrane proteins

(2013) Nicholas Noinaj et al.   NATURE

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

(2013) Stefan G. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New antibiotic agents in the pipeline and how they can help overcome microbial resistance

(2013) Ian M. Gould et al.   Virulence

Structural reorganization of the bacterial cell-division protein FtsZ fromStaphylococcus aureus

(2012) Takashi Matsui et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Myxobacterium-Produced Antibiotic TA (Myxovirescin) Inhibits Type II Signal Peptidase

(2012) Yao Xiao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Antibiotic That Inhibits a Late Step in Wall Teichoic Acid Biosynthesis Induces the Cell Wall Stress Stimulon in Staphylococcus aureus

(2012) Jennifer Campbell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluorescein Analogues Inhibit SecA ATPase: The First Sub-micromolar Inhibitor of Bacterial Protein Translocation

(2012) Ying-Ju Huang et al.   ChemMedChem

Mechanism of Action of the Cell-Division Inhibitor PC190723: Modulation of FtsZ Assembly Cooperativity

(2012) Nathaniel L. Elsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Geographic Variability and Anti-Staphylococcal Activity of the Chrysophaentins and Their Synthetic Fragments

(2012) Jessica L. Keffer et al.   Marine Drugs

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to  -Lactam Antibiotics

(2012) C. M. Tan et al.   Science Translational Medicine

Fluorescence and Atomic Force Microscopy Imaging of Wall Teichoic Acids inLactobacillus plantarum

(2011) Guillaume Andre et al.   ACS Chemical Biology

β-Barrel Membrane Protein Assembly by the Bam Complex

(2011) Christine L. Hagan et al.   Annual Review of Biochemistry

The Bam machine: A molecular cooper

(2011) Dante P. Ricci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

SecA, a remarkable nanomachine

(2011) Ilja Kusters et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes

(2011) Nathalie T. Reichmann et al.   FEMS MICROBIOLOGY LETTERS

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses inStaphylococcus aureus

(2010) Jennifer Campbell et al.   ACS Chemical Biology

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Lipoprotein Sorting in Bacteria

(2010) Suguru Okuda et al.   Annual Review of Microbiology

The first low μM SecA inhibitors

(2010) Weixuan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Glycosylation of Wall Teichoic Acid inStaphylococcus aureusby TarM

(2010) Guoqing Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

(2010) David J. Haydon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chrysophaentins A−H, Antibacterial Bisdiarylbutene Macrocycles That Inhibit the Bacterial Cell Division Protein FtsZ

(2010) Alberto Plaza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Biogenesis of Outer Membranes in Gram-Negative Bacteria

(2009) Hajime TOKUDA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Wall Teichoic Acid Function, Biosynthesis, and Inhibition

(2009) Jonathan G. Swoboda et al.   CHEMBIOCHEM

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

(2009) Joann Huber et al.   CHEMISTRY & BIOLOGY

Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis

(2009) Kathrin Schirner et al.   EMBO JOURNAL

The wall teichoic acid and lipoteichoic acid polymers of Staphylococcus aureus

(2009) Guoqing Xia et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

(2009) Ranjana Pathania et al.   Nature Chemical Biology

Discovery of the first SecA inhibitors using structure-based virtual screening

(2008) Minyong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Probing FtsZ and Tubulin with C8-Substituted GTP Analogs Reveals Differences in Their Nucleotide Binding Sites

(2008) Tilman Läppchen et al.   CHEMISTRY & BIOLOGY

Treatment ofClostridium difficileInfection

(2008) Dale N. Gerding et al.   CLINICAL INFECTIOUS DISEASES

Functional Analysis of the Protein Machinery Required for Transport of Lipopolysaccharide to the Outer Membrane of Escherichia coli

(2008) P. Sperandeo et al.   JOURNAL OF BACTERIOLOGY

Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coli

(2008) N. Ruiz   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

(2008) N. Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

(2008) D. J. Haydon et al.   SCIENCE