Article
Gastroenterology & Hepatology
Jinghua Jin, Zhi Xu, Lina Zhang, Can Zhang, Xiaoduo Zhao, Yuxuan Mao, Haojian Zhang, Xingguang Liang, Juanli Wu, Ying Yang, Jing Zhang
Summary: Peripheral beta-amyloid (A beta), including gut-derived A beta, is believed to contribute to the formation of A beta plaques in the brain, and the gut microbiota has an impact on Alzheimer's disease (AD) through the gut-brain axis. This study investigated the potential interactions among gut-derived A beta, gut microbiota, and AD pathogenesis. The results showed that the gut is a critical source of A beta in the brain, and gut microbiota can upregulate A beta production in the gut, potentially contributing to AD pathogenesis.
Review
Medicine, Research & Experimental
Periyanaina Kesika, Natarajan Suganthy, Bhagavathi Sundaram Sivamaruthi, Chaiyavat Chaiyasut
Summary: Gut microbiota plays a crucial role in the development of Alzheimer's disease (AD) through dysbiosis, leading to inflammatory signaling pathway disturbances that promote neuroinflammation and neuronal death. Understanding the relationship between gut microbiota and CNS can help identify probiotic-based supplementation as a potential therapeutic option for AD.
Article
Multidisciplinary Sciences
Yuchu Liu, Ji-an Wei, Zhihua Luo, Jing Cui, Yifan Luo, Sarah Oi Kwan Mak, Siqi Wang, Fengwei Zhang, Yan Yang, Kwok-Fai So, Lingling Shi, Li Zhang, Billy Kwok Chong Chow
Summary: Salt homeostasis is regulated by neural circuits and peripheral endocrine factors. The colon, a primary site for electrolyte absorption, might play a role in modulating sodium intake. This study discovered that the gastrointestinal hormone secretin, released from colon endocrine cells during sodium deficiency, is crucial for inducing salt appetite. Circulating secretin activates specific receptors in the nucleus of the solitary tracts, which in turn activates the downstream para-ventricular nucleus of the hypothalamus, resulting in increased sodium intake. These findings reveal a previously unknown gut-brain pathway for the timely regulation of sodium homeostasis.
Review
Immunology
Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li
Summary: Recent investigations suggest that dietary consumption of flavonoids has neuroprotective effects by inhibiting neuroinflammatory and oxidative stress responses. Flavonoids may also shape gut microbiota composition and promote the growth of beneficial bacteria that produce neuroprotective metabolites. By influencing the microbiota-gut-brain axis, flavonoids indirectly improve brain health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Tarkan Karakan, Ceren Ozkul, Esra Kupeli Akkol, Saniye Bilici, Eduardo Sobarzo-Sanchez, Raffaele Capasso
Summary: The composition and function of gut microbiota play a crucial role in functional gastrointestinal disorders, with a bidirectional communication between the gut and the central nervous system. Antibiotic-induced dysbiosis is identified as a significant factor for the occurrence of these disorders, affecting the gut-brain axis and potentially leading to cognitive and mood disorders. Both animal and human trials provide strong evidence for the causal relationship between gut microbiota and brain functions, highlighting new therapeutic implications for pathogenic pathways.
Review
Immunology
Yan-hao Wei, Ren-tang Bi, Yan-mei Qiu, Chun-lin Zhang, Jian-zhuang Li, Ya-nan Li, Bo Hu
Summary: The complex relationship between the brain and gastrointestinal tract has significant implications for ischemic stroke. Experimental evidence suggests that changes in the gastrointestinal microenvironment, including alterations in immune response, disruption of the gastrointestinal barrier, and modification of the gut microbiota, can contribute to the infiltration of immune cells and cytokines into the ischemic brain. Understanding the importance of brain-gastrointestinal crosstalk after stroke may offer potential therapeutic interventions for improving stroke prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jian Lu, Wenlong Hou, Sunan Gao, Ye Zhang, Youming Zong
Summary: With the aging of the world population, more elderly patients are undergoing anesthesia and surgery, leading to increasing attention towards perioperative neurocognitive dysfunction (PND). PND includes preoperatively cognitive impairment, postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction, and the role of the gut microbiota-gut-brain axis in its pathogenesis remains unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Jonathan P. Jacobs, Arpana Gupta, Ravi R. Bhatt, Jacob Brawer, Kan Gao, Kirsten Tillisch, Venu Lagishetty, Rebecca Firth, Gregory D. Gudleski, Benjamin M. Ellingson, Jennifer S. Labus, Bruce D. Naliboff, Jeffrey M. Lackner, Emeran A. Mayer
Summary: This study found that pre-treatment intestinal microbiota and serotonin levels can predict the response to CBT in IBS patients. Responders to CBT showed changes in brain connectivity and microbiome post-treatment, indicating potential top-down effects of the brain on the microbiome during CBT.
Review
Food Science & Technology
Zhongxing Chu, Shuai Han, Yi Luo, Yaping Zhou, Lingfeng Zhu, Feijun Luo
Summary: This review systematically examined the effects of dietary flavonoids on gut microbes and their metabolites, concluding that flavonoids can improve cognitive function through the gut-brain axis. Flavonoids can be absorbed through the intestine, cross the blood-brain barrier, and enter brain tissue, exerting anti-inflammatory, antioxidant, neuroprotective and anti-apoptotic effects, thus ameliorating age-related cognitive disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Immunology
Juli Choi, Bo-Ram Kim, Begum Akuzum, Leechung Chang, June-Yong Lee, Ho-Keun Kwon
Summary: The human gastrointestinal tract has a diverse microbiota that is important for immune system development and tissue homeostasis. Dysbiosis of the microbiota is associated with various diseases. Regulatory T cells (Tregs) play a crucial role in maintaining immunological homeostasis and tolerance in barrier regions. The gut microbiota influences the development, accumulation, and function of Tregs. Recent studies have found that Tregs interact with resident cells in the central nervous system (CNS) to limit the progression of neurological disorders. The gut-brain axis is functionally connected and Tregs play a role in this interaction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan
Summary: Periodontitis-related salivary microbiota may exacerbate the pathogenesis of Alzheimer's disease through the gut-brain axis. In this study, the gavage of periodontitis-related salivary microbiota in APP(swe)/PS1(Delta E9) transgenic mice impaired cognitive function, increased beta-amyloid accumulation and neuroinflammation, along with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation.
Article
Nutrition & Dietetics
Jeanne Neuffer, Raul Gonzalez-Dominguez, Sophie Lefevre-Arbogast, Dorrain Y. Low, Benedicte Driollet, Catherine Helmer, Andrea Du Preez, Chiara de Lucia, Silvie R. Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Sandrine Thuret, Claudine Manach, Merce Pallas, Mireia Urpi-Sarda, Alex Sanchez-Pla, Cristina Andres-Lacueva, Cecilia Samieri
Summary: The gut microbiome plays a role in influencing cognition via the gut-brain axis. Higher serum levels of propionic acid, a short-chain fatty acid, were found to be associated with increased odds of cognitive decline. This effect may be mediated by hypercholesterolemia and diabetes.
Review
Neurosciences
Yael-Natalie H. Escobar, Devin O'Piela, Loren E. Wold, Amy R. Mackos
Summary: The gut microbiota plays a crucial role in the development of Alzheimer's disease and can communicate with the brain directly or indirectly through various signaling molecules. Interventions like probiotic supplementation have shown promise in improving cognitive function.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Moira Marizzoni, Peppino Mirabelli, Elisa Mombelli, Luigi Coppola, Cristina Festari, Nicola Lopizzo, Delia Luongo, Monica Mazzelli, Daniele Naviglio, Jean-Louis Blouin, Marc Abramowicz, Marco Salvatore, Michela Pievani, Annamaria Cattaneo, Giovanni B. Frisoni
Summary: This study investigates the association between gut microbiota and the amyloid cascade in sporadic AD, and examines the potential mediators of the microbiota-gut-brain axis. It finds that specific bacterial genera are associated with immune and endothelial markers, and these markers are associated with amyloid cascade markers in sporadic AD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Pharmacology & Pharmacy
Tejaswini Doifode, Vijayasree V. Giridharan, Jaqueline S. Generoso, Gursimrat Bhatti, Allan Collodel, Paul E. Schulz, Orestes Forlenza, Tatiana Barichello
Summary: Recent studies have shown the impact of the gut microbiota on various neurodegenerative diseases, including Alzheimer's disease. Understanding the role of the microbiota may offer new targets for treatment to delay, progress, or reverse AD, as well as potentially reducing the prevalence of the disease.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Toxicology
Yisheng He, Wei Lian, Liang Ding, Xiaoyu Fan, Jiang Ma, Qing-Yu Zhang, Xinxin Ding, Ge Lin
Summary: This study revealed the essential role of hepatic P450 enzymes in the bioactivation of PAs and the subsequent lung injury caused by circulating metabolites. The results provide scientific evidence for the application of MCT in animal lung injury models and emphasize the importance of investigating lung diseases associated with exposure to various PAs.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Toxicology
Jiang Ma, Wei Zhang, Yisheng He, Lin Zhu, Chunyuan Zhang, Jia Liu, Yang Ye, Yuzheng Zhuge, Ge Lin
Summary: The study suggests that pyrrole-hemoglobin adducts may serve as a more suitable biomarker for pyrrolizidine alkaloid (PAs) exposure, with higher concentrations and longer persistence compared to pyrrole-plasma protein adducts.
ARCHIVES OF TOXICOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Chung Man, Jessica Hui, Peng Du, Yuen Hang Julia Liu, Zengbing Lu, Dexuan Cui, Bing Jiang, Man Piu Ngan, Shuk Han Ng, Lingqing Yang, Aleena Khalid, Luping Liu, John A. Rudd
Article
Food Science & Technology
Lin Zhu, Junyi Xue, Yisheng He, Qingsu Xia, Peter P. Fu, Ge Lin
Summary: Pyrrolizidine alkaloids (PAs) are common hepatotoxic phytotoxins found in over 6000 plants worldwide. They are metabolized by hepatic cytochrome P450 enzymes into reactive pyrrolic metabolites, which can alkylate cellular proteins and DNA, leading to cytotoxicity, genotoxicity, and tumorigenicity. In this study, positive correlations were found among PA-derived liver DNA adducts, liver protein adducts, and serum protein adducts, with serum pyrrole-protein adducts showing higher abundance and accessibility as a suitable surrogate biomarker for pyrrole-DNA adducts.
Article
Pharmacology & Pharmacy
Zengbing Lu, Dexuan Cui, Julia Yuen Hang Liu, Bin Jiang, Man Piu Ngan, Ichiro Sakata, Shota Takemi, Takafumi Sakai, Ge Lin, Sze Wa Chan, John A. Rudd
Summary: NESFATIN-1, encoded by NUCB2, is a potent regulator of feeding and emesis in Suncus murinus, with its expression level in the brain and gastrointestinal tract being influenced by fasting. It can induce emesis, suppress food intake and water intake, but has no significant effect on locomotor activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Halina Was, Agata Borkowska, Ana Bagues, Longlong Tu, Julia Y. H. Liu, Zengbing Lu, John A. Rudd, Kulmira Nurgali, Raquel Abalo
Summary: Chemotherapeutic drugs are extensively used in cancer treatment, but their severe side effects on the nervous system can reduce the efficacy of treatment and patients' quality of life. This review discusses the main effects of chemotherapy on the peripheral and central nervous systems, including neuropathic pain, chemobrain, enteric neuropathy, as well as nausea and emesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Polina Len, Gaukhar Iskakova, Zarina Sautbayeva, Aigul Kussanova, Ainur T. Tauekelova, Madina M. Sugralimova, Anar S. Dautbaeva, Meruert M. Abdieva, Eugene D. Ponomarev, Alexander Tikhonov, Makhabbat S. Bekbossynova, Natasha S. Barteneva
Summary: This study examined the association between coagulation parameters and COVID-19 infection severity through a meta-analysis. The results showed that most coagulation parameters, except for platelets, were significantly elevated in patients with severe COVID-19. D-dimers and fibrinogen levels were found to have the strongest association with disease severity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Tangtang Xiang, Dongyi Feng, Xinjie Zhang, Yupeng Chen, Hanhua Wang, Xuanhui Liu, Zhitao Gong, Jiangyuan Yuan, Mingqi Liu, Zhuang Sha, Chuanxiang Lv, Weiwei Jiang, Meng Nie, Yibing Fan, Di Wu, Shiying Dong, Jiancheng Feng, Eugene D. Ponomarev, Jianning Zhang, Rongcai Jiang
Summary: This study found that increased intracranial pressure significantly impacts the glymphatic-lymphatic fluid transport system (GLFTS), and this impact depends on the severity of the intracranial pressure. These findings have translational applications in the prevention and treatment of related neurological disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Editorial Material
Pharmacology & Pharmacy
Kulmira Nurgali, John A. Rudd, Halina Was, Raquel Abalo
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Tatyana Veremeyko, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev
Summary: The complement system plays an important role in immune defense and also has important functions in the central nervous system (CNS). Recent studies have shown that complement subunits C1q, C4, and C3 have roles in synapse pruning and neurologic pathologies. C4B deficiency or low expression is related to the development of schizophrenia and autism spectrum disorders through mechanisms not related to synapse elimination. C4B has a role in the regulation of immediate early gene expression and downstream targets during CNS insults such as epileptic seizures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Julia Yuen Hang Liu, John A. Rudd
Summary: Electrical data from a drug database was used to train artificial intelligence for predicting drug adverse effects and exploring correlations with gastrointestinal pacemaker activity.
SCIENTIFIC REPORTS
(2023)
Review
Food Science & Technology
Galina Nugumanova, Eugene D. Ponomarev, Sholpan Askarova, Elizaveta Fasler-Kan, Natasha S. Barteneva
Summary: Cyanobacteria produce a variety of cyanotoxins and cyanopeptides that have both acute and long-term neurotoxic effects. These compounds can block proteins and channels, inhibit essential enzymes, and cause mistranslation of proteins, leading to neuronal death and neurodegeneration. The production of cyanopeptides and non-canonical amino acids is an ancient mechanism that may disrupt gut microorganisms and affect mitochondrial function in neurons. Understanding this interaction is crucial for targeting or preventing neurodegenerative diseases.
Meeting Abstract
Gastroenterology & Hepatology
Chung Man Jessica Hui, Peng Du, Yuen Hang Julia Liu, Zengbing Lu, Man Piu Ngan, Dexuan Cui, Bin Jiang, Shuk Hang Ng, Lingqing Yang, Aleena Khalid, Luping Liu, John A. Rudd