A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic‐related cytokine release syndrome

SARS-CoV-2: a storm is raging

(2020) Savannah F. Pedersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of a TGN1412 analogue using in vitro assays and two immune humanized mouse models

(2019) Hangyi Yan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BLT-immune humanized mice as a model for nivolumab induced immune-mediated adverse events: Comparison of the NOG and NOG-EXL strains

(2019) James L Weaver et al.   TOXICOLOGICAL SCIENCES

Humanized mouse models of immunological diseases and precision medicine

(2019) Leonard D. Shultz et al.   MAMMALIAN GENOME

Evaluation of the Ability of Immune Humanized Mice to Demonstrate CD20-Specific Cytotoxicity Induced by Ofatumumab

(2019) Kenrick M. Semple et al.   CTS-Clinical and Translational Science

Bone marrow-liver-thymus (BLT) immune humanized mice as a model to predict cytokine release syndrome

(2019) Hangyi Yan et al.   Translational Research

Considerations for the Design of Antibody-Based Therapeutics

(2019) Dennis R. Goulet et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Current Perspectives in Cancer Immunotherapy

(2019) Theodoulakis Christofi et al.   Cancers

New and Worsening Long‐term Immune‐Related Adverse Events with PD‐1/PD‐L1 Pathway Agents in Patients with Cancer

(2019) Kevin H. Hall et al.   PHARMACOTHERAPY

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

Lack of acute xenogeneic graft-versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression

(2018) Michael A. Brehm et al.   FASEB JOURNAL

The Future of Immunotherapy: A 20-Year Perspective

(2017) David C. Wraith   Frontiers in Immunology

Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions

(2016) Christine Grimaldi et al.   CYTOKINE

TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model

(2016) Sabrina Weißmüller et al.   PLoS One

Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases

(2015) Yuping Lai et al.   INTERNATIONAL IMMUNOLOGY

Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm

(2015) S. Vessillier et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Mechanisms of action of therapeutic antibodies for cancer

(2015) J.M. Redman et al.   MOLECULAR IMMUNOLOGY

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

(2015) Cameron McDonald-Hyman et al.   Science Translational Medicine

Cytokine release assays: Current practices and future directions

(2014) D. Finco et al.   CYTOKINE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors

(2012) P. H. Miller et al.   BLOOD

A humanised mouse model of cytokine release: Comparison of CD3-specific antibody fragments

(2012) S.L. Malcolm et al.   JOURNAL OF IMMUNOLOGICAL METHODS

After TGN1412: Recent developments in cytokine release assays

(2012) R. Stebbings et al.   Journal of Immunotoxicology

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

(2010) M Wunderlich et al.   LEUKEMIA

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Non-obese diabetic-recombination activating gene-1 (NOD-Rag 1null) interleukin (IL)-2 receptor common gamma chain (IL 2 rγnull) null mice: a radioresistant model for human lymphohaematopoietic engraftment

(2008) T. Pearson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

(2007) Marie King et al.   CLINICAL IMMUNOLOGY