Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm

Published 2015 View Full Article

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Title
Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm
Authors
Keywords
Cytokine release assay, Group size, Whole blood, PBMC, Therapeutic mAb, TGN1412
Journal
JOURNAL OF IMMUNOLOGICAL METHODS
Volume 424, Issue -, Pages 43-52
Publisher
Elsevier BV
Online
2015-05-07
DOI
10.1016/j.jim.2015.04.020

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