JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling

A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-κB Activity

(2019) Yajie Li et al.   JOURNAL OF IMMUNOLOGY

mTOR inhibition by metformin impacts monosodium urate crystal–induced inflammation and cell death in gout: a prelude to a new add-on therapy?

(2019) Nadia Vazirpanah et al.   ANNALS OF THE RHEUMATIC DISEASES

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?

(2019) Silvio Danese et al.   GUT

Distal Consequences of Oral Inflammation

(2019) Joanne E. Konkel et al.   Frontiers in Immunology

Minocycline Preserves the Integrity and Permeability of BBB by Altering the Activity of DKK1–Wnt Signaling in ICH Model

(2019) Guoqing Wang et al.   NEUROSCIENCE

mTOR Inhibitor Therapy Diminishes Circulating CD8+ CD28- Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-Refractory Renal Allograft Rejection

(2019) Cyd M. Castro-Rojas et al.   TRANSPLANTATION

Cytokines in Inflammatory Disease

(2019) Shinwan Kany et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling

(2019) Dongqiang Yang et al.   MOLECULAR IMMUNOLOGY

The multifaceted link between inflammation and human diseases

(2018) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The oral microbiota: dynamic communities and host interactions

(2018) Richard J. Lamont et al.   NATURE REVIEWS MICROBIOLOGY

Ubiquitination in Periodontal Disease: A Review

(2017) Sachio Tsuchida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of Wnt3a and Dkk1 in experimental periodontitis

(2017) Jianqi Liu et al.   Journal of Dental Sciences

JAK inhibitors in dermatology: The promise of a new drug class

(2017) William Damsky et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt–Wnt Situation

(2017) Tomás Villaseñor et al.   Frontiers in Immunology

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis

(2017) Hui Zhang et al.   CIRCULATION

LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974

(2017) Jaewoong Jang et al.   Scientific Reports

Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human

(2017) Brice Nativel et al.   Scientific Reports

Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells

(2016) S-H Wang et al.   ONCOGENE

Major neutrophil functions subverted by Porphyromonas gingivalis

(2016) Ingar Olsen et al.   Journal of Oral Microbiology

2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes

(2015) Huizhi Wang et al.   INFLAMMATION RESEARCH

Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside

(2015) Yoshiya Tanaka   JOURNAL OF BIOCHEMISTRY

Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway byPorphyromonas gingivalisGingipains RgpA, RgpB, and Kgp

(2015) Masaaki Nakayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway

(2015) Hyunjoon Kim et al.   Cell Reports

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

Porphyromonas gingivalis Exacerbates Ligature-Induced, RANKL-Dependent Alveolar Bone Resorption via Differential Regulation of Toll-Like Receptor 2 (TLR2) and TLR4

(2014) Jiang Lin et al.   INFECTION AND IMMUNITY

Porphyromonas gingivalis-Induced Reactive Oxygen Species Activate JAK2 and Regulate Production of Inflammatory Cytokines through c-Jun

(2014) Huizhi Wang et al.   INFECTION AND IMMUNITY

Acute Pulmonary Lipopolysaccharide Tolerance Decreases TNF-  without Reducing Neutrophil Recruitment

(2014) S. Natarajan et al.   JOURNAL OF IMMUNOLOGY

A Wnt/β-catenin negative feedback loop represses TLR-triggered inflammatory responses in alveolar epithelial cells

(2014) Yong Li et al.   MOLECULAR IMMUNOLOGY

The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages

(2014) Maria Ruweka Fernando et al.   PLoS One

Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway

(2013) Makoto Ishikawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

Breaking bad: Manipulation of the host response byPorphyromonas gingivalis

(2013) George Hajishengallis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Porphyromonas gingivalis Lipopolysaccharide Activates Canonical Wnt/β-Catenin and p38 MAPK Signalling in Stem Cells from the Apical Papilla

(2013) Jia Wang et al.   INFLAMMATION

Role of Janus Kinase 3 in Mucosal Differentiation and Predisposition to Colitis

(2013) Jayshree Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of JAK-3 in Regulating TLR-Mediated Inflammatory Cytokine Production in Innate Immune Cells

(2013) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View

(2013) Wibke Schulte et al.   MEDIATORS OF INFLAMMATION

Unknown

(2013) Karina Adamowicz et al.   MOLECULAR MEDICINE

Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

(2013) Thanuja D. K. Herath et al.   PLoS One

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation

(2012) Hideyuki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

(2012) G. Hajishengallis et al.   Molecular Oral Microbiology

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

(2012) Peter J Murray et al.   NATURE IMMUNOLOGY

Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity

(2012) Kevin B. Stacey et al.   PLoS One

Nedd4-2 Modulates Renal Na+-Cl- Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

(2011) J. P. Arroyo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage

(2011) Q. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses

(2010) Kolja Schaale et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages

(2010) Jan Neumann et al.   FASEB JOURNAL

Salmonellaregulation of intestinal stem cells through the Wnt/β-catenin pathway

(2010) Xingyin Liu et al.   FEBS LETTERS

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

(2009) Roland Axmann et al.   ARTHRITIS AND RHEUMATISM

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Sensors of the innate immune system: their mode of action

(2009) Roberto Baccala et al.   Nature Reviews Rheumatology

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY