Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes

(2016) Benjamin A. Kandel et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Rifampin-warfarin interaction in a mitral valve replacement patient receiving rifampin for infective endocarditis: a case report

(2016) Amr Mohamed Fahmi et al.   SpringerPlus

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

(2015) Roger B. Ruggeri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR

(2015) Javed A. Khan et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of drug interactions when medications are stopped: the often forgotten risks

(2014) Erica Y Tong et al.   MEDICAL JOURNAL OF AUSTRALIA

Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature

(2013) Maria AP Martins et al.   BMC Pharmacology & Toxicology

Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence

(2012) Yi Ling Teo et al.   BREAST CANCER RESEARCH AND TREATMENT

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

(2011) Patrick M. Dansette et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Current In Vitro High Throughput Screening Approaches to Assess Nuclear Receptor Activation

(2011) Judy L. Raucy et al.   CURRENT DRUG METABOLISM

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

(2010) Jacob A. Kaizerman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors

(2010) Kurt Zimmermann et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

(2010) S. J. Shukla et al.   DRUG METABOLISM AND DISPOSITION

Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12receptor blockade and inhibition of platelet aggregation after clopidogrel

(2010) H. M. JUDGE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Update on Rifampin and Rifabutin Drug Interactions

(2009) Anne M. Baciewicz et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11β-HSD1 inhibitors

(2009) Yosup Rew et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

(2009) M. Kazui et al.   DRUG METABOLISM AND DISPOSITION

Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical

(2008) Michael Sinz et al.   AAPS Journal

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

(2008) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model

(2008) Christopher Fotsch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

(2008) Jean-Philippe Collet et al.   LANCET

Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability

(2008) W. Wang et al.   PROTEIN ENGINEERING DESIGN & SELECTION