Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome

Mechanistic Characterization of a 2-Thioxanthine Myeloperoxidase Inhibitor and Selectivity Assessment Utilizing Click Chemistry–Activity-Based Protein Profiling

(2013) Jessica Ward et al.   BIOCHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of Novel 3-Alkylindole Derivatives as Selective and Highly Potent Myeloperoxidase Inhibitors

(2013) Jalal Soubhye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis

(2013) Greta Wozniak et al.   MEDICAL SCIENCE MONITOR

Structural basis for action by diverse antidepressants on biogenic amine transporters

(2013) Hui Wang et al.   NATURE

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Simultaneous measurement of protein-bound 3-chlorotyrosine and homocitrulline by LC–MS/MS after hydrolysis assisted by microwave: Application to the study of myeloperoxidase activity during hemodialysis

(2012) Cédric Delporte et al.   TALANTA

Effects of Fluoxetine on the Oxidative Status of Peripheral Blood Leucocytes of Restraint-Stressed Mice

(2011) Silvia Novío et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

(2011) Anna-Karin Tidén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Biomarkers of inflammation and oxidative stress in atherosclerosis

(2010) Kiyoko Uno et al.   Biomarkers in Medicine

Basic Principles of Platelet Biology and Clinical Implications

(2010) Dominick J. Angiolillo et al.   CIRCULATION JOURNAL

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

(2010) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson's Disease

(2010) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

Structure-Based Design, Synthesis, and Pharmacological Evaluation of 3-(Aminoalkyl)-5-fluoroindoles as Myeloperoxidase Inhibitors

(2010) Jalal Soubhye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformationally Restricted Homotryptamines. Part 7: 3-cis-(3-Aminocyclopentyl)indoles As Potent Selective Serotonin Reuptake Inhibitors

(2010) H. Dalton King et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluoxetine inhibition of 5-HT-potentiated platelet aggregation in whole blood

(2010) Vasileios G. Bampalis et al.   THROMBOSIS AND HAEMOSTASIS

A selective serotonin reuptake inhibitor, citalopram, inhibits collagen-induced platelet aggregation and activation

(2010) Yu-Lun Tseng et al.   THROMBOSIS RESEARCH

Stuck in a rut: rethinking depression and its treatment

(2010) Paul E. Holtzheimer et al.   TRENDS IN NEUROSCIENCES

Depression research: where are we now?

(2010) Saebom Lee et al.   Molecular Brain

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

(2009) Valdecir F. Ximenes et al.   BIOCHEMICAL JOURNAL

Protective effects of antidepressants against chronic fatigue syndrome - induced behavioral changes and biochemical alterations

(2009) Anil Kumar et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

A new easy method for specific measurement of active myeloperoxidase in human biological fluids and tissue extracts

(2009) T. Franck et al.   TALANTA

Association of Major Depressive Disorder with Serum Myeloperoxidase and Other Markers of Inflammation: A Twin Study

(2008) Viola Vaccarino et al.   BIOLOGICAL PSYCHIATRY

Patent issues relating to hybrid drugs

(2008) John Richards   EXPERT OPINION ON THERAPEUTIC PATENTS

Binding of Serotonin to the Human Serotonin Transporter. Molecular Modeling and Experimental Validation

(2008) Leyla Celik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH