Histone deacetylases in modulating cardiac disease and their clinical translational and therapeutic implications

Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats

(2019) Maria Assunta Potenza et al.   PLoS One

HDAC inhibition as a therapeutic strategy in myocardial ischemia/reperfusion injury

(2019) Min Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Histone deacetylases in cardiovascular and metabolic diseases

(2019) Rushita A. Bagchi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

(2019) Rebecca L McIntyre et al.   EMBO Molecular Medicine

Inhibition of histone deacetylases in melanoma-a perspective from bench to bedside

(2016) Eva Hornig et al.   EXPERIMENTAL DERMATOLOGY

Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat Is Associated with IL-6/Stat3 Signaling in Ischemic Heart Failure

(2015) Hikmet Nural-Guvener et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Histone Deacetylase Inhibitor Modulates Cardiac Peroxisome Proliferator-Activated Receptors and Inflammatory Cytokines in Heart Failure

(2015) Baigalmaa Lkhagva et al.   PHARMACOLOGY

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

(2014) Lindsey B. Gano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

(2014) George A. Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling

(2014) Saisudha Koka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling

(2014) Kimberly M. Demos-Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Regulation of Acetylation of Histone Deacetylase 2 by p300/CBP-Associated Factor/Histone Deacetylase 5 in the Development of Cardiac Hypertrophy

(2014) Gwang Hyeon Eom et al.   CIRCULATION RESEARCH

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

(2014) Sara L. Lewandowski et al.   HUMAN MOLECULAR GENETICS

Epigenetic mechanisms underlying cardiac degeneration and regeneration

(2014) Pankaj Chaturvedi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes

(2014) Sarah M. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart

(2014) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Posttranslational modifications of histone deacetylases: Implications for cardiovascular diseases

(2014) Gwang Hyeon Eom et al.   PHARMACOLOGY & THERAPEUTICS

Sirtuin 1 (SIRT1) Activation Mediates Sildenafil Induced Delayed Cardioprotection against Ischemia-Reperfusion Injury in Mice

(2014) Mona Shalwala et al.   PLoS One

Downregulation of HDAC1 Is Involved in the Cardiomyocyte Differentiation from Mesenchymal Stem Cells in a Myocardial Microenvironment

(2014) Dong-feng Lu et al.   PLoS One

Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy

(2014) Patrick M. McLendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC4: mechanism of regulation and biological functions

(2014) Zhengke Wang et al.   Epigenomics

Distinct patterns of histone modifications at cardiac-specific gene promoters between cardiac stem cells and mesenchymal stem cells

(2013) Meijing Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Current Genetics and Epigenetics of Smoking/Tobacco-Related Cardiovascular Disease

(2013) Lutz P. Breitling   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways

(2013) Yong-guang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetics in the heart: the role of histone modifications in cardiac remodelling

(2013) Asmita Tingare et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart

(2013) Emily J Cox et al.   Cardiovascular Diabetology

Histone deacetylase signaling in cardioprotection

(2013) Lorenz H. Lehmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure

(2013) Yu-Hsun Kao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy

(2013) B. S. Ferguson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

(2013) Koralia E. Paschalaki et al.   STEM CELLS

HDAC-dependent ventricular remodeling

(2013) Min Xie et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Metabolic Characterization of a Sirt5 deficient mouse model

(2013) Jiujiu Yu et al.   Scientific Reports

Genetics and epigenetics of arrhythmia and heart failure

(2013) Burcu Duygu et al.   Frontiers in Genetics

Trichostatin A Ameliorates Myocardial Ischemia/Reperfusion Injury Through Inhibition of Endoplasmic Reticulum Stress-induced Apoptosis

(2012) Ling Yu et al.   ARCHIVES OF MEDICAL RESEARCH

SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB

(2012) Chun-Juan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetics and Cardiovascular Disease

(2012) Andrew L.H. Webster et al.   CANADIAN JOURNAL OF CARDIOLOGY

Emerging role of epigenetics and miRNA in diabetic cardiomyopathy

(2012) Mohamed Asrih et al.   CARDIOVASCULAR PATHOLOGY

SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes

(2012) Matteo Becatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

Environmental exposures, epigenetics and cardiovascular disease

(2012) Andrea Baccarelli et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

(2012) Chao Tong et al.   FASEB JOURNAL

Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2

(2012) Eneda Hoxha et al.   PLoS One

Epigenetic Programming and Risk: The Birthplace of Cardiovascular Disease?

(2012) Maria Cristina Vinci et al.   Stem Cell Reviews and Reports

Histone Deacetylase 1 Deficiency Impairs Differentiation and Electrophysiological Properties of Cardiomyocytes Derived from Induced Pluripotent Cells

(2012) Eneda Hoxha et al.   STEM CELLS

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

Epigenetics and Cardiovascular Development

(2011) Ching-Pin Chang et al.   Annual Review of Physiology

Casein Kinase-2α1 Induces Hypertrophic Response by Phosphorylation of Histone Deacetylase 2 S394 and its Activation in the Heart

(2011) Gwang Hyeon Eom et al.   CIRCULATION

Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions

(2011) Chary López-Pedrera et al.   Clinical & Developmental Immunology

Epigenetics in cardiovascular disease

(2011) Apurva V Shirodkar et al.   CURRENT OPINION IN CARDIOLOGY

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

(2011) Johannes Backs et al.   JOURNAL OF CELL BIOLOGY

Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy

(2011) Nagalingam R. Sundaresan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension

(2011) Douglas D. Lemon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

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(2011) Timothy McKinsey   MOLECULAR MEDICINE

Targeted deletion of NF-κB p50 diminishes the cardioprotection of histone deacetylase inhibition

(2010) L. X. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

gp-91 mediates histone deacetylase inhibition-induced cardioprotection

(2010) Ting C. Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes

(2010) Agnieszka Biala et al.   BLOOD PRESSURE

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy

(2010) Hae Jin Kee et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes

(2010) Shinji Kaichi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy

(2010) Xudong Liao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Isoform-selective HDAC inhibitors: Closing in on translational medicine for the heart

(2010) Timothy A. McKinsey   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells

(2010) Yi-Jiun Weng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epigenetics and cardiovascular disease

(2010) José M. Ordovás et al.   Nature Reviews Cardiology

Histone deacetylase inhibitors: Keeping momentum for neuromuscular and cardiovascular diseases treatment

(2010) Claudia Colussi et al.   PHARMACOLOGICAL RESEARCH

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy

(2010) C. H. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

(2010) O. M. Dovey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic modifications and human pathologies: cancer and CVD

(2010) Susan J. Duthie   PROCEEDINGS OF THE NUTRITION SOCIETY

Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness

(2009) Wenting Zhu et al.   CIRCULATION RESEARCH

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

(2009) Angela Nebbioso et al.   EMBO REPORTS

Suberoylanilide hydroxamic acid promotes cardiomyocyte differentiation of rat mesenchymal stem cells

(2009) Chuan Feng et al.   EXPERIMENTAL CELL RESEARCH

Endothelin-Stimulated Human B-Type Natriuretic Peptide Gene Expression Is Mediated by Yin Yang 1 in Association With Histone Deacetylase 2

(2009) Denis J. Glenn et al.   HYPERTENSION

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of resveratrol on H2O2-induced apoptosis and expression of SIRTs in H9c2 cells

(2009) Wei Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy

(2009) Hae Jin Kee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy

(2009) Shin-ichi Oka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice

(2009) R. S. F. Oliveira et al.   JOURNAL OF PHYSIOLOGY-LONDON

HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2

(2008) Annamaria Scognamiglio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1

(2008) Zhiqiang Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

(2008) Pasquale Gallo et al.   CARDIOVASCULAR RESEARCH

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

(2008) Tetsuro Ago et al.   CELL

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Activation of Histone Deacetylase 2 by Inducible Heat Shock Protein 70 in Cardiac Hypertrophy

(2008) Hae Jin Kee et al.   CIRCULATION RESEARCH

Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient: How Do New Pieces Fit into the Uremic Puzzle?

(2008) P. Stenvinkel et al.   Clinical Journal of the American Society of Nephrology

Reprogramming the cell cycle machinery to treat cardiovascular disease

(2008) K BICKNELL et al.   CURRENT OPINION IN PHARMACOLOGY

From Natural Products to Small Molecule Ketone Histone Deacetylase Inhibitors: Development of New Class Specific Agents

(2008) Philip Jones et al.   CURRENT PHARMACEUTICAL DESIGN

Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos

(2008) Pengpeng Ma et al.   DEVELOPMENTAL BIOLOGY

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

(2008) Anne Granger et al.   FASEB JOURNAL

SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 ζ and BAD in H9c2 cells

(2008) Edward G. Lynn et al.   FEBS LETTERS

HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity

(2008) Mahesh P. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic Overexpression of Hdac3 in the Heart Produces Increased Postnatal Cardiac Myocyte Proliferation but Does Not Induce Hypertrophy

(2008) Chinmay M. Trivedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol exerts pharmacological preconditioning by activating PGC-1α

(2008) Lan Tan et al.   MEDICAL HYPOTHESES

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

YY1 Protects Cardiac Myocytes from Pathologic Hypertrophy by Interacting with HDAC5

(2008) Carmen C. Sucharov et al.   MOLECULAR BIOLOGY OF THE CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY