Review
Environmental Sciences
Ingra Tais Malacarne, Daniel Vitor De Souza, Barbara Dos Anjos Rosario, Milena De Barros Viana, Camilo Dias Seabra Pereira, Debora Estadella, Jean Nunes dos Santos, Daniel Araki Ribeiro
Summary: Crack-cocaine can induce genotoxicity and oxidative stress in mammalian cells, and studies have shown evidence supporting its role as a chemical carcinogen. However, the impact of inflammatory response after exposure to crack-cocaine remains inconclusive.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Maria Rachele Guascito, Maria Giulia Lionetto, Franco Mazzotta, Marianna Conte, Maria Elena Giordano, Roberto Caricato, Anna Rita De Bartolomeo, Adelaide Dinoi, Daniela Cesari, Eva Merico, Laura Mazzotta, Daniele Contini
Summary: In this study, the toxicity of atmospheric particulate matter (PM) was investigated through in vitro experiments. The results showed correlations between extracellular and intracellular toxicity indicators, and significant effects of combustion sources on these toxicity indicators. Additionally, the advection of African dust resulted in lower intrinsic toxicity indicators.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Toxicology
Nancy B. Andrioli, Gabriela Chaufan
Summary: The study evaluated the genotoxicity and oxidative stress in the A549 cell line exposed to sublethal concentrations of Iprodione. The increase in Iprodione concentrations slightly raised the probability of belonging to the genotoxic category, while oxidative stress analysis showed a significant linear increase in SOD and a significant linear decrease in GSH and GST.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Iteb Boughattas, Nesrine Zitouni, Marouane Mkhinini, Omayma Missawi, Sondes Helaoui, Sabrine Hattab, Moncef Mokni, Noureddine Bousserrhine, Mohamed Banni
Summary: This study investigated the effects of biochar on earthworms in soil remediation. The results showed that in the presence of biochar, the bioavailability of Cd and 2,4-D increased in earthworms, along with an increase in micronuclei frequency and a decrease in lysosomal membrane stability. Histopathological examination revealed numerous alterations in animals exposed to contaminants without any amelioration when biochar was added. The biochemical response of earthworms demonstrated that in the presence of biochar, animals tended to alleviate the toxicity of Cd and 2,4-D.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Una Stamenovic, Sladana Davidovic, Sandra Petrovic, Andreja Leskovac, Milovan Stoiljkovic, Vesna Vodnik
Summary: Two Ag-PANI/PVP nanocomposites with similar silver content but different morphologies were prepared by integrating silver nanoparticles during oxidative polymerization. These nanocomposites showed strong antimicrobial potential against indicator microbial strains, making them suitable for non-medical applications like wastewater treatment.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Andrea Malkova, Tereza Svadlakova, Avni Singh, Martina Kolackova, Radka Vankova, Pavel Borsky, Drahomira Holmannova, Adam Karas, Lenka Borska, Zdenek Fiala
Summary: The study revealed a significant dose-dependent increase in DNA damage when human THP-1 cell line was exposed to two types of graphene platelets in vitro. However, there was no observed increase in cytotoxicity, immunotoxicity, or cytostasis.
Article
Environmental Sciences
Sabrine Hattab, Iteb Boughattas, Tiziana Cappello, Nesrine Zitouni, Ghada Touil, Ilef Romdhani, Alexandre Livet, Nourreddine Bousserrhine, Mohamed Banni
Summary: Heavy metal pollution has harmful consequences on soil fertility, and earthworms are used as test organisms to evaluate the ecotoxicity of polluted soils. This study exposed Eisenia andrei to polymetallic contaminated soils for 7 and 14 days in southeastern Tunisia. The results showed increased heavy metal accumulation, genotoxicity, and cytotoxicity in earthworms after 14 days of exposure, as well as changes in biochemical and transcriptional responses. These findings support the use of earthworms as bioindicator species for pollution monitoring and provide valuable information about the harmful impact of biota exposure to contaminated soils.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Kamila Rybczynska-Tkaczyk, Bartosz Skora, Konrad A. Szychowski
Summary: The aim of this study was to determine the toxicity of bisphenol A (BPA) and its derivatives on various organisms. The results showed that BPA, BPS, and BPF exhibited high toxicity on bacteria, reaching concentrations of 0.018-0.031 mg/L. These compounds also showed genotoxicity and cytotoxicity effects on human cells, as well as phytotoxicity effects on plants. The findings suggest that BPA and its derivatives have a negative impact on living organisms through apoptosis and genotoxic mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biophysics
Masoud Eskandani, Morteza Eskandani, Somayeh Vandghanooni, Bahman Navidshad, Farzad Mirzaei Aghjehgheshlagh, Ali Nobakht
Summary: This study successfully enhanced the bioavailability of L-carnitine (LC) using solid lipid nanoparticles (SLNs) as carriers and demonstrated the protective effects of LC-SLNs against intracellular oxidative stress damages.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Environmental
Dong Zhang, Hanhan Li, Xiao-San Luo, Weijie Huang, Yuting Pang, Jinshan Yang, Mingwei Tang, Tariq Mehmood, Zhen Zhao
Summary: Dust storm represents a global air pollution and health issue, and this study found that heavy metals concentrations in PMs were lower during dust storms, which correlated with cytotoxicity. PM2.5 exhibited greater toxicity compared to PM10, but they had similar potential in inducing proinflammatory cytokines.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Environmental Sciences
Jianjun Li, Jin Li, Gehui Wang, Kin Fai Ho, Jing Han, Wenting Dai, Can Wu, Cong Cao, Lang Liu
Summary: This study found that the oxidative potential induced by winter PM2.5 samples was higher than that induced by summer samples, but the seasonal variations of inflammatory factors were opposite. Secondary aerosols formation significantly contributed to the oxidative potential of PM2.5 in both seasons, with biomass burning being a significant source in winter.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biology
Omer Hazman, Hatice Evin, Mehmet Fatih Bozkurt, Ibrahim Hakki Cigerci
Summary: The study found that low concentrations of alpha-arbutin had no genotoxic and cytotoxic effects on HepG2 cells, while when used with cisplatin, it could decrease oxidative stress, inflammation, and genotoxicity levels. High concentrations of alpha-arbutin showed anticarcinogenic effects by increasing oxidative stress, genotoxicity, inflammation, and apoptosis, and by suppressing proliferation.
Article
Environmental Sciences
Xingfan Li, Shakir Ullah, Ning Chen, Xin Tong, Nan Yang, Jia Liu, Xiaorui Guo, Zhonghua Tang
Summary: Microplastic (MP) pollution is a critical environmental issue. Dandelions have the potential to be a biomonitor for assessing the phytotoxicity of MPs pollution, especially the highly toxic PS. However, the ecotoxicology of MPs in dandelions remains unclear. This study investigates the toxic effects of different types of plastics on dandelion germination and early seedling growth, and identifies sensitive biomarkers of dandelion contamination by MPs.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Monika Sharma, Nikhil Maheshwari, Fahim Halim Khan, Riaz Mahmood
Summary: The extensive use of harmful pesticides in agriculture, including Carbendazim (CBZ), poses serious threats to the environment and human health. CBZ has been found to cause various health problems, including endocrine disruption, embryo toxicity, and neurodegenerative disorders.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Qiuyin Zhu, Biyu Wu, Ling Zhao
Summary: The study found that N-acetylhistamine can kill Heterosigma akashiwo cells through oxidative stress, while also reducing its toxicity. In addition, the treatment with N-AcH resulted in decreased chlorophyll content in H. akashiwo, as well as a reduction in fatty acid types and content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ping Guo, Shen Chen, Daochuan Li, Jinmiao Zhang, Jiao Luo, Aihua Zhang, Dianke Yu, Michael S. Bloom, Liping Chen, Wen Chen
ENVIRONMENTAL POLLUTION
(2020)
Article
Biochemistry & Molecular Biology
Xu Chen, Shen Chen, Tianran Shen, Wenqi Yang, Qian Chen, Peiwen Zhang, Yiran You, Xiaoyuan Sun, Huihui Xu, Yi Tang, Jiaxin Mi, Yan Yang, Wenhua Ling
Article
Toxicology
Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen
PARTICLE AND FIBRE TOXICOLOGY
(2020)
Article
Environmental Sciences
Menghui Jiang, Daochuan Li, Jinmei Piao, Jianyu Li, Hao Sun, Liping Chen, Shen Chen, Jingbo Pi, Rong Zhang, Rui Chen, Shuguang Leng, Wen Chen, Yuxin Zheng
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Pharmacology & Pharmacy
Qixiao Jiang, Chao Zhang, Shen Chen, Limei Shi, Dao Chuan Li, Na Lv, Lianhua Cui, Yanxia Chen, Yuxin Zheng
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Environmental Sciences
Zhengbao Zhang, Xiumei Xing, Shuyun Jiang, Chunfang Qiu, Ziying Mo, Shen Chen, Liping Chen, Qing Wang, Yongmei Xiao, Guanghui Dong, Yuxin Zheng, Wen Chen, Daochuan Li
Summary: Exposure to PAHs in coke oven workers leads to a decrease in global H3K79me2 levels, which is negatively correlated with the concentration of 1-OHP in urine and DNA damage. In HBE cells, BaP inhibits H3K79me2. The study found that DOT1L is the sole methyltransferase for H3K79, and BaP repression on H3K79me2 is induced by inhibiting DOT1L expression.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Peiwen Zhang, Shen Chen, Huanwen Tang, Wanjun Fang, Ke Chen, Xu Chen
Summary: This study demonstrates that Coenzyme Q10 protects against acetaminophen-induced liver injury by activating mitophagy, reducing oxidative stress levels, and promoting mitochondrial complex activities, therefore representing a potential therapeutic option for drug-induced liver injury.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Xu Chen, Jinghe Xiao, Juan Pang, Shen Chen, Qing Wang, Wenhua Ling
Summary: The study suggests that pancreatic beta-cell function may be a new predictor for the presence of NAFLD, and insufficient compensatory beta-cell function is associated with NAFLD.
Article
Engineering, Environmental
Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, Michael Aschner, Yuxin Zheng, Lihua Zhang, Wen Chen, Daochuan Li
Summary: The study showed that the PP2A-mTOR-p70S6K/4E-BP1 signaling pathway plays a critical role in mediating macrophage M1 polarization, contributing to PM-induced pulmonary injury.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Letter
Gastroenterology & Hepatology
Xu Chen, Shen Chen, Juan Pang, Yi Tang, Wenhua Ling
JOURNAL OF HEPATOLOGY
(2021)
Article
Toxicology
Shen Chen, Yi Tang, Wanjun Fang, Taiping He, Xu Chen, Peiwen Zhang
Summary: CoQ10 treatment remains effective at the late stage of APAP-induced ALI and promotes resolution of necrosis and liver regeneration.
TOXICOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ziwei Wang, Hui Peng, Rui Zhang, Xinhang Jiang, Shen Chen, Ping Guo, Yongmei Xiao, Xiaowen Zeng, Qing Wang, Michael Aschner, Wei-chun Chou, Daochuan Li, Wen Chen, Liping Chen
Summary: Assessing intestinal injury caused by hexavalent chromium (Cr-VI) in humans is important for quantifying the adverse health risks associated with the intake of Cr (VI)-contaminated water. This study developed an in vitro gastrointestinal digestion (IVGD) model that incorporated a human intestinal epithelial model and modified the constituents of simulated gastric fluid to better simulate human gastric reduction and intestinal absorption. The results showed that weak gastric acidity significantly increased the intestinal accessible dose of Cr-VI. Prolonged intestinal exposure destroyed the intestinal epithelium, and 24 hours after Cr-VI treatment was identified as a suitable time point for intestinal absorption and toxicity assessment. Cell-based bioassays indicated that epithelial integrity was the most sensitive marker for Cr-VI toxicity assessment. This study provides a feasible strategy for studying Cr-VI biotransformation and intestinal injury following ingestion exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Shen Chen, Daochuan Li, Dianke Yu, Miao Li, Lizhu Ye, Yue Jiang, Shijie Tang, Rui Zhang, Chi Xu, Shuyun Jiang, Ziwei Wang, Michael Aschner, Yuxin Zheng, Liping Chen, Wen Chen
Summary: The study identified specific DNB genes that, when manipulated, led to significant changes in malignant phenotypes of lung cancer. The core DNB genes were found to be involved in regulating lung cancer cell growth and showed synergistic effects in the initiation and development of lung cancers induced by PM2.5.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Hongliang Xue, Xu Chen, Chao Yu, Yuqing Deng, Yuan Zhang, Shen Chen, Xuechen Chen, Ke Chen, Yan Yang, Wenhua Ling
Summary: This study identifies a previously unknown link between a specific gut microbiota-derived tryptophan metabolite (IPA) and atherosclerotic cardiovascular disease (ASCVD). Experimental results demonstrate that supplementation of IPA can alleviate the development of atherosclerosis and promote cholesterol efflux in macrophages through a specific signaling pathway. This finding may represent a promising therapeutic target for ASCVD.
CIRCULATION RESEARCH
(2022)
Article
Toxicology
Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li, Wen Chen
Summary: This study demonstrates that immunosuppression via the IL-17A pathway plays a critical role in the initiation of chronic lung injuries upon sub-chronic PM exposure. Depletion of IL-17A leads to a significant decline in chronic lung injuries, mainly triggered by reduced recruitment of myeloid-derived suppressor cells (MDSCs) and downregulation of TGF-beta.
PARTICLE AND FIBRE TOXICOLOGY
(2022)