Characterization and stabilization in process development and product formulation for super large proteinaceous particles

In-situ and sensitive stability study of emulsion and aluminum adjuvanted inactivated foot-and-mouth disease virus vaccine by differential scanning fluorimetry analysis

(2020) Yanmin Song et al.   VACCINE

Mechanism of bio-macromolecule denaturation on solid-liquid surface of ion-exchange chromatographic media – A case study for inactivated foot-and-mouth disease virus

(2020) Yanli Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Current challenges in biotherapeutic particles manufacturing

(2019) Mafalda G. Moleirinho et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Asymmetrical Flow Field-Flow Fractionation on Virus and Virus-Like Particle Applications

(2019) Katri Eskelin et al.   Microorganisms

Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

(2019) Helena Bigares Grangeia et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Selective counting and sizing of single virus particles using fluorescent aptamer-based nanoparticle tracking analysis

(2018) Zoltán Szakács et al.   Nanoscale

Field-flow fractionation: A gentle separation and characterization technique in biomedicine

(2018) Xiaoyue Zhang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Analytical Techniques to Characterize the Structure, Properties, and Assembly of Virus Capsids

(2018) Panagiotis Kondylis et al.   ANALYTICAL CHEMISTRY

Strong hydrophobicity enables efficient purification of HBc VLPs displaying various antigen epitopes through hydrophobic interaction chromatography

(2018) Zhengjun Li et al.   BIOCHEMICAL ENGINEERING JOURNAL

A two-step heat treatment of cell disruption supernatant enables efficient removal of host cell proteins before chromatographic purification of HBc particles

(2018) Zhengjun Li et al.   JOURNAL OF CHROMATOGRAPHY A

Quantification and characterization of virus-like particles by size-exclusion chromatography and nanoparticle tracking analysis

(2017) Petra Steppert et al.   JOURNAL OF CHROMATOGRAPHY A

AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations

(2017) Simon Pacouret et al.   MOLECULAR THERAPY

One single, fast and robust capillary electrophoresis method for the direct quantification of intact adenovirus particles in upstream and downstream processing samples

(2017) Ewoud van Tricht et al.   TALANTA

Stabilization study of inactivated foot and mouth disease virus vaccine by size-exclusion HPLC and differential scanning calorimetry

(2017) Yanli Yang et al.   VACCINE

Thermal Stability as a Determinant of AAV Serotype Identity

(2017) Antonette Bennett et al.   Molecular Therapy-Methods & Clinical Development

Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples

(2016) Nichola C. Garbett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Study of intact virus-like particles of human papillomavirus by capillary electrophoresis

(2016) Virginie Bettonville et al.   ELECTROPHORESIS

Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015)

(2016) Sami El Deeb et al.   ELECTROPHORESIS

Nanoparticle tracking analysis of particle size and concentration detection in suspensions of polymer and protein samples: Influence of experimental and data evaluation parameters

(2016) Julia Gross et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Size distribution analysis of influenza virus particles using size exclusion chromatography

(2016) Judith Vajda et al.   JOURNAL OF CHROMATOGRAPHY A

High-throughput characterization of virus-like particles by interlaced size-exclusion chromatography

(2016) Christopher Ladd Effio et al.   VACCINE

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Formulation and stabilization of recombinant protein based virus-like particle vaccines

(2015) Nishant K. Jain et al.   ADVANCED DRUG DELIVERY REVIEWS

Size Characterization and Quantification of Exosomes by Asymmetrical-Flow Field-Flow Fractionation

(2015) Simona Sitar et al.   ANALYTICAL CHEMISTRY

Improved virus purification processes for vaccines and gene therapy

(2015) Piergiuseppe Nestola et al.   BIOTECHNOLOGY AND BIOENGINEERING

Adsorption of virus-like particles on ion exchange surface: Conformational changes at different pH detected by dual polarization interferometry

(2015) Yanli Yang et al.   JOURNAL OF CHROMATOGRAPHY A

Microcalorimetric study of adsorption and disassembling of virus-like particles on anion exchange chromatography media

(2015) Mengran Yu et al.   JOURNAL OF CHROMATOGRAPHY A

A hydrophobic interaction chromatography strategy for purification of inactivated foot-and-mouth disease virus

(2015) Hao Li et al.   PROTEIN EXPRESSION AND PURIFICATION

Size-exclusion HPLC provides a simple, rapid, and versatile alternative method for quality control of vaccines by characterizing the assembly of antigens

(2015) Yanli Yang et al.   VACCINE

Aggregation and antigenicity of virus like particle in salt solution—A case study with hepatitis B surface antigen

(2015) Yi Chen et al.   VACCINE

Foot-and-mouth disease vaccination induces cross-reactive IFN-γ responses in cattle that are dependent on the integrity of the 140S particles

(2015) Danilo Bucafusco et al.   VIROLOGY

Characterization of human papillomavirus 6b L1 virus-like particles isolated from silkworms using capillary zone electrophoresis

(2014) Thomas Hahne et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Robust manufacturing and comprehensive characterization of recombinant hepatitis E virus-like particles in Hecolin®

(2014) Xiao Zhang et al.   VACCINE

Quantitative real-time single particle analysis of virions

(2014) Susanne Heider et al.   VIROLOGY

Bioengineering virus-like particles as vaccines

(2013) Linda H.L. Lua et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quantitation of influenza virus using field flow fractionation and multi-angle light scattering for quantifying influenza A particles

(2013) Tatiana Bousse et al.   JOURNAL OF VIROLOGICAL METHODS

Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics

(2013) V. Rayaprolu et al.   JOURNAL OF VIROLOGY

Virus-like particle formulation optimization by miniaturized high-throughput screening

(2013) Johannes Mohr et al.   METHODS

Characterization and comparative performance of lentiviral vector preparations concentrated by either one-step ultrafiltration or ultracentrifugation

(2013) Eleni Papanikolaou et al.   VIRUS RESEARCH

High-yield and scalable cell-free assembly of virus-like particles by dilution

(2012) Mervyn W.O. Liew et al.   BIOCHEMICAL ENGINEERING JOURNAL

Poliovirus separation from cell extracts using capillary electrophoresis: Potential use in vaccine production and control?

(2012) Iuliana Oita et al.   JOURNAL OF VIROLOGICAL METHODS

A plate-based high-throughput assay for virus stability and vaccine formulation

(2012) Thomas S. Walter et al.   JOURNAL OF VIROLOGICAL METHODS

A Rational, Systematic Approach for the Development of Vaccine Formulations

(2011) Garry L. Morefield   AAPS Journal

Rational design and optimization of downstream processes of virus particles for biopharmaceutical applications: Current advances

(2011) Tiago Vicente et al.   BIOTECHNOLOGY ADVANCES

Asymmetrical flow field-flow fractionation technique for separation and characterization of biopolymers and bioparticles

(2011) G. Yohannes et al.   JOURNAL OF CHROMATOGRAPHY A

Significance of the pH-induced conformational changes in the structure of C-reactive protein measured by dual polarization interferometry

(2010) Bor-Ching Sheu et al.   BIOSENSORS & BIOELECTRONICS

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens inCervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

(2010) Michel Deschuyteneer et al.   Human vaccines & immunotherapeutics

Measuring number-concentrations of nanoparticles and viruses in liquids on-line

(2010) Shangfeng Du et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Modeling protein binding and elution over a chromatographic surface probed by surface plasmon resonance

(2010) Tiago Vicente et al.   JOURNAL OF CHROMATOGRAPHY A

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

(2010) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Recent trends and some applications of isothermal titration calorimetry in biotechnology

(2009) L. Selva Roselin et al.   Biotechnology Journal

Quality-control issues and approaches in vaccine development

(2009) Bernard Metz et al.   Expert Review of Vaccines

Applications of isothermal titration calorimetry in protein science

(2008) Yi Liang   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response

(2008) Bethany Hansen et al.   VACCINE