Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut

Leveraging the Gut to Treat Metabolic Disease

(2020) Ruth E. Gimeno et al.   Cell Metabolism

The Regulation of Peripheral Metabolism by Gut-Derived Hormones

(2019) Emily W. L. Sun et al.   Frontiers in Endocrinology

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

(2019) Helmuth Gehart et al.   CELL

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3–induced cell cycle arrest

(2019) R. Sergio Solorzano-Vargas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development

(2019) Xinghao Zhang et al.   DEVELOPMENTAL CELL

Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine

(2018) Natalia Petersen et al.   GASTROENTEROLOGY

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

(2018) Joep Beumer et al.   NATURE CELL BIOLOGY

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

(2018) Deborah A. Goldspink et al.   Molecular Metabolism

Recent updates on GLP-1 agonists: Current advancements & challenges

(2018) Dilip Sharma et al.   BIOMEDICINE & PHARMACOTHERAPY

Deriving functional human enteroendocrine cells from pluripotent stem cells

(2018) Katie L. Sinagoga et al.   DEVELOPMENT

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

(2018) Masayuki Fujii et al.   Cell Stem Cell

The Role of GLP-1 in the Metabolic Success of Bariatric Surgery

(2017) Chelsea R Hutch et al.   ENDOCRINOLOGY

Costorage of Enteroendocrine Hormones Evaluated at the Cell and Subcellular Levels in Male Mice

(2017) Linda J. Fothergill et al.   ENDOCRINOLOGY

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

(2017) Judith Kraiczy et al.   GUT

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

(2017) J J Worthington et al.   Mucosal Immunology

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Heterogeneity of enterochromaffin cells within the gastrointestinal tract

(2017) S. Diwakarla et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Signalling in the gut endocrine axis

(2017) Fiona M Gribble et al.   PHYSIOLOGY & BEHAVIOR

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

(2016) Paul W. Tetteh et al.   Cell Stem Cell

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

(2016) Kaare V. Grunddal et al.   ENDOCRINOLOGY

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology

(2016) Daniel J. Drucker   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential

(2015) Stefanie Gross et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

(2015) Sapna Puri et al.   Cell Stem Cell

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

Intestinal organoids for assessing nutrient transport, sensing and incretin secretion

(2015) Tamara Zietek et al.   Scientific Reports

Gastric emptying and glycaemia in health and diabetes mellitus

(2014) Liza K. Phillips et al.   Nature Reviews Endocrinology

Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

(2014) Sabine Middendorp et al.   STEM CELLS

Enteroendocrine hormones—central effects on behavior

(2013) Karolina P Skibicka et al.   CURRENT OPINION IN PHARMACOLOGY

Generation of L Cells in Mouse and Human Small Intestine Organoids

(2013) N. Petersen et al.   DIABETES

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry

(2012) Abdella M. Habib et al.   ENDOCRINOLOGY

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Classification and functions of enteroendocrine cells of the lower gastrointestinal tract

(2011) Ashok R. Gunawardene et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a

(2010) T. Miyatsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE