Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

Genome-wide association study of peripheral artery disease in the Million Veteran Program

(2019) Derek Klarin et al.   NATURE MEDICINE

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

(2019) Rajeev Malhotra et al.   NATURE GENETICS

Transcriptional and epigenetic regulation of macrophages in atherosclerosis

(2019) Tatyana Kuznetsova et al.   Nature Reviews Cardiology

The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

(2019) Matthias Prestel et al.   STROKE

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

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Robust research needs many lines of evidence

(2018) Marcus R. Munafò et al.   NATURE

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

(2018) Christian L. Lino Cardenas et al.   Nature Communications

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

(2018) Marnix Lameijer et al.   Nature Biomedical Engineering

Clinician’s Guide to Reducing Inflammation to Reduce Atherothrombotic Risk

(2018) Paul M Ridker   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo

(2017) Yaw Asare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

(2017) Sonja Reißig et al.   Nature Communications

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

(2017) Paola A. Betancur et al.   Nature Communications

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

(2016) William Herrington et al.   CIRCULATION RESEARCH

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

Low-frequency and common genetic variation in ischemic stroke

(2016) Rainer Malik et al.   NEUROLOGY

HDAC9 Variant Rs2107595 Modifies Susceptibility to Coronary Artery Disease and the Severity of Coronary Atherosclerosis in a Chinese Han Population

(2016) Xue-bin Wang et al.   PLoS One

Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors

(2016) Marion Lapierre et al.   Oncotarget

The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

(2015) Jizheng Chen et al.   DIABETES

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis

(2015) Annette E. Neele et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Histone Deacetylase 9 Represses Cholesterol Efflux and Alternatively Activated Macrophages in Atherosclerosis Development

(2014) Qiang Cao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions

(2014) Jan Van den Bossche et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atherosclerotic Plaque Destabilization

(2014) Carlos Silvestre-Roig et al.   CIRCULATION RESEARCH

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

(2014) M. A. Hoeksema et al.   EMBO Molecular Medicine

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease

(2014) Tapan K Chatterjee et al.   Adipocyte

Histone Deacetylase 9 Promotes Angiogenesis by Targeting the Antiangiogenic MicroRNA-17–92 Cluster in Endothelial Cells

(2013) David Kaluza et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

(2013) Peter Libby et al.   IMMUNITY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

(2013) Mercedes Lobera et al.   Nature Chemical Biology

Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis

(2013) Hugh S. Markus et al.   STROKE

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

(2012) Céline Bellenguez et al.   NATURE GENETICS

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis

(2011) B. Zhou et al.   CARDIOVASCULAR RESEARCH

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

(2010) Rita Moreno et al.   NUCLEIC ACIDS RESEARCH

Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow

(2009) Anna Zampetaki et al.   CIRCULATION