Article
Multidisciplinary Sciences
Beatriz Bano-Otalora, Franck Martial, Court Harding, David A. Bechtold, Annette E. Allen, Timothy M. Brown, Mino D. C. Belle, Robert J. Lucas
Summary: The study reveals an impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, with lower daytime irradiance leading to a marked reduction in the amplitude of spontaneous activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Arthur H. Cheng, Samuel W. Fung, Sara Hegazi, Osama Hasan Mustafa Hasan Abdalla, Hai-Ying Mary Cheng
Summary: The hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, and the transcription factor Sox2 plays a crucial role in controlling the expression of circadian neuropeptides and transcription factors in the embryonic SCN. Sox2 deficiency leads to reduced survival of SCN neurons during the postnatal period, but does not affect progenitor cell proliferation or SCN specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Raymond E. A. Sanchez, Franck Kalume, Horacio O. de la Iglesia
Summary: Nearly all mammals have robust daily rhythms called circadian rhythms, which are controlled by a master clock in the hypothalamus and affect various biological processes. This review summarizes the current understanding of circadian regulation of sleep, including neural circuitry, molecular mechanisms, and developmental regulation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biology
Beatriz Bano-Otalora, Matthew J. Moye, Timothy Brown, Robert J. Lucas, Casey O. Diekman, Mino D. C. Belle
Summary: The study revealed that SCN neurons in the diurnal rodent Rhabdomys pumilio are more excited during daytime hours, but their evoked activity includes a suppressive response not present in nocturnal rodents. By investigating the evoked electrical activity, researchers confirmed the key role of transient subthreshold A-type potassium channels in this response.
Review
Neurosciences
Mariana Astiz, Lina Maria Delgado-Garcia, Laura Lopez-Mascaraque
Summary: Astrocytes have gained importance in building brain circuits and regulating complex behavior alongside neurons. The circadian system synchronizes physiological processes in mammals such as sleep-wake cycle and cognition. Recent breakthrough discoveries have implicated astrocytes as essential time-keepers in addition to neurons in the suprachiasmatic nucleus.
Article
Neurosciences
Vendula Luzna, Pavel Houdek, Karolina Liska, Alena Sumova
Summary: During fetal development, maternal signaling can impact the developing clock in the suprachiasmatic nuclei. Disruption of maternal signaling due to disturbances in the light/dark cycle can lead to changes in gene expression profiles in the fetal SCN. The fetal SCN is highly sensitive to various changes in maternal signaling related to environmental disturbances, showing gene-specific responses.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Victoria M. Alvord, Elizabeth J. Kantra, Julie S. Pendergast
Summary: Circadian rhythms are 24-hour cycles of behavior and physiology generated by molecular clocks in various tissues. The suprachiasmatic nucleus (SCN) serves as the main circadian clock in mammals, receiving light information and coordinating tissue clocks. Estrogens play a role in regulating biological processes and behavior by interacting with circadian genes. This review focuses on the interplay between estrogens and the circadian system in female rodents, summarizing current understanding of their effects.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Floriana Mogavero, Kitty Zwieten, Jan K. Buitelaar, Jeffrey C. Glennon, Marloes J. A. G. Henckens
Summary: The study found that aggressive BALB/cJ mice showed deviations in various components related to circadian rhythm and hormone levels, including a shorter free-running period in constant darkness, reduced variability in state corticosterone levels, lower testosterone levels, and alterations in the expression of specific proteins in the suprachiasmatic nucleus.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Hana Mikova, Viktor Kuchtiak, Irena Svobodova, Veronika Spisska, Dominika Pacesova, Ales Balik, Zdenka Bendova
Summary: The study evaluated the circadian rhythmicity of AMPA receptor GluA2 subunit in the SCN and other brain structures in Wistar rats, revealing differences in expression patterns and correlations in different brain regions.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Deborah A. M. Joye, Kayla E. Rohr, Kimberlee Suenkens, Alissa Wuorinen, Thomas Inda, Madeline Arzbecker, Emma Mueller, Alec Huber, Harshida Pancholi, Murray G. Blackmore, Vania Carmona-Alcocer, Jennifer A. Evans
Summary: Daily and annual changes in light are processed by central clock circuits. The role of somatostatin (SST) in the response of the suprachiasmatic nucleus (SCN) to light has not been examined. Our study shows that SST signaling regulates daily rhythms in behavior and SCN function, with sex-specific effects. Lack of SST signaling increases circadian plasticity and eliminates sex differences in photic responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Behavioral Sciences
Pawan Kumar Jha, Hanan Bouaouda, Andries Kalsbeek, Etienne Challet
Summary: The master clock in the SCN uses environmental light to synchronize circadian rhythms, while behavioral arousal disrupts the circadian system and alters molecular functions of pacemaker cells, affecting nocturnal and diurnal animals differently. Further research is needed to understand circadian impairments associated with shift work and trans-meridian travel in both nocturnal and diurnal animal models.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Michael Moldavan, Olga Cravetchi, Charles N. Allen
Summary: This study revealed the presence of a tonic current mediated by GABA(A) receptors containing alpha 4-, alpha 5-, and delta-subunits in the suprachiasmatic nucleus. The amplitude of this current strongly relies on action potential-mediated synaptic release of GABA. The equilibrium potential for this tonic current corresponds to that of GABA(A) currents. The frequency of GABA(A) postsynaptic currents and the amplitude of the tonic current increase during the day, reaching a peak in the middle of the day and gradually declining with a nadir at night, showing a diurnal rhythm.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Somaye Mesgar, Seyed Behnamedin Jameie, Abbas Aliaghaei, Siavash Parvardeh, Abolfazl Torabi, Abbas Haghparast
Summary: The study investigated the effects of dopamine D1 agonist on clock gene expressions and behavioral activities in adult male Wistar rats, showing that the agonist increased Per2 and CLOCK expressions during daytime but decreased Per1 and Bmal1 expressions. Moreover, the dopamine D1 agonist only increased Per2 expression significantly during nighttime and decreased Per1, CLOCK, and Bmal1 expressions. Overall, these findings suggest that exogenous dopamine administration can alter clock gene expressions and behavioral activities in rats.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Somaye Mesgar, Kiarash Eskandari, Habib Karimian-Sani-Varjovi, Paria Salemi-Mokri-Boukani, Abbas Haghparast
Summary: The present study aimed to investigate the role of D1-like dopamine receptors (D1Rs) in SCN neural oscillations during the 24-h light-dark cycle using local field potential (LFP) recording. The results showed that the D1Rs agonist administration in the morning dramatically altered these intrinsic oscillations, decreasing delta and theta relative power, and promoting most of the higher frequency bands and LZC index. Some of these effects were reversed at night after the SKF-38393 injection.
NEUROCHEMICAL RESEARCH
(2023)
Review
Clinical Neurology
Michelle Y. Cheng, Markus Aswendt, Gary K. Steinberg
Article
Behavioral Sciences
Alex G. Lee, Roxanne Capanzana, Jacqueline Brockhurst, Michelle Y. Cheng, Christine L. Buckmaster, Devin Absher, Alan F. Schatzberg, David M. Lyons
NEUROBIOLOGY OF LEARNING AND MEMORY
(2016)
Article
Clinical Neurology
Arjun V. Pendharkar, Sabrina L. Levy, Allen L. Ho, Eric S. Sussman, Michelle Y. Cheng, Gary K. Steinberg
NEUROSURGICAL FOCUS
(2016)
Article
Neurosciences
Peng Wang, Rong Xie, Michelle Cheng, Robert Sapolsky, Xunming Ji, Heng Zhao
NEUROSCIENCE LETTERS
(2018)
Article
Clinical Neurology
Masaki Ito, Markus Aswendt, Alex G. Lee, Shunsuke Ishizaka, Zhijuan Cao, Eric H. Wang, Sabrina L. Levy, Daniel L. Smerin, Jennifer A. McNab, Michael Zeineh, Christoph Leuze, Maged Goubran, Michelle Y. Cheng, Gary K. Steinberg
Article
Multidisciplinary Sciences
Aatman M. Shah, Shunsuke Ishizaka, Michelle Y. Cheng, Eric H. Wang, Alex R. Bautista, Sabrina Levy, Daniel Smerin, Guohua Sun, Gary K. Steinberg
SCIENTIFIC REPORTS
(2017)
Review
Clinical Neurology
L. C. Wu, Y. Zhang, G. Steinberg, H. Qu, S. Huang, M. Cheng, T. Bliss, F. Du, J. Rao, G. Song, L. Pisani, T. Doyle, S. Conolly, K. Krishnan, G. Grant, M. Wintermark
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Article
Neurosciences
Lauren N. Miterko, Kenneth B. Baker, Jaclyn Beckinghausen, Lynley V. Bradnam, Michelle Y. Cheng, Jessica Cooperrider, Mahlon R. DeLong, Simona V. Gornati, Mark Hallett, Detlef H. Heck, Freek E. Hoebeek, Abbas Z. Kouzani, Sheng-Han Kuo, Elan D. Louis, Andre Machado, Mario Manto, Alana B. McCambridge, Michael A. Nitsche, Nordeyn Oulad Ben Taib, Traian Popa, Masaki Tanaka, Dagmar Timmann, Gary K. Steinberg, Eric H. Wang, Thomas Wichmann, Tao Xie, Roy V. Sillitoe
Article
Multidisciplinary Sciences
Maged Goubran, Christoph Leuze, Brian Hsueh, Markus Aswendt, Li Ye, Qiyuan Tian, Michelle Y. Cheng, Ailey Crow, Gary K. Steinberg, Jennifer A. McNab, Karl Deisseroth, Michael Zeineh
NATURE COMMUNICATIONS
(2019)
Review
Clinical Neurology
Zhijuan Cao, Sean S. Harvey, Tonya M. Bliss, Michelle Y. Cheng, Gary K. Steinberg
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Arjun Pendharkar, Daniel Smerin, Lorenzo Gonzalez, Eric H. Wang, Sabrina Levy, Stephanie Wang, Shunsuke Ishizaka, Masaki Ito, Haruto Uchino, Terrance Chiang, Michelle Y. Cheng, Gary K. Steinberg
Summary: Post-stroke optogenetic stimulation and systemic nNOS inhibition both lead to functional improvements after stroke, suggesting a potentially maladaptive role of nNOS in post-stroke recovery.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Zhijuan Cao, Sean S. Harvey, Terrance Chiang, Aulden G. Foltz, Alex G. Lee, Michelle Y. Cheng, Gary K. Steinberg
Summary: This study investigated the spatiotemporal changes in the secondary degenerative thalamus post-stroke, revealing early microglial activation and later neurodegeneration. Transcriptome analysis at PD28 showed a higher number of differentially expressed genes in the thalamus, with neuroinflammation being the top activated pathway and microglia the most enriched cell type. Additionally, a unique subtype of microglia (CD11c(+)) with features of neurodegenerative disease-associated microglia was identified in the degenerative thalamus after stroke.
Article
Multidisciplinary Sciences
Shahabeddin Vahdat, Arjun Vivek Pendharkar, Terrance Chiang, Sean Harvey, Haruto Uchino, Zhijuan Cao, Anika Kim, ManKin Choy, Hansen Chen, Hyun Joo Lee, Michelle Y. Cheng, Jin Hyung Lee, Gary K. Steinberg
Summary: Poststroke optogenetic stimulations in mice can restore activation of ipsilesional corticothalamic and corticocortical circuits, which is correlated with functional recovery. Stimulation of the corticothalamic circuit alone is sufficient to improve functional recovery after stroke. These findings suggest early involvement of the corticothalamic circuit as a key mediator of poststroke recovery.
Article
Clinical Neurology
Kumar Abhinav, Alex G. G. Lee, Arjun V. V. Pendharkar, Mark Bigder, Anthony Bet, Yael Rosenberg-Hasson, Michelle Y. Y. Cheng, Gary K. K. Steinberg
Summary: Moyamoya disease (MMD) is characterized by progressive occlusion of the intracranial internal carotid arteries, leading to ischemic and hemorrhagic events. This study found that the cerebrospinal fluid of MMD patients contained elevated levels of various factors, including PDGF-BB, PAI-1, and ICAM1, which may be involved in the pathogenesis and potential therapeutic targets of MMD.
TRANSLATIONAL STROKE RESEARCH
(2023)