C1orf109L binding DHX9 promotes DNA damage depended on the R‐loop accumulation and enhances camptothecin chemosensitivity

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

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Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination

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RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

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Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes

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DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

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RNA-DNA hybrid (R-loop) immunoprecipitation mapping: an analytical workflow to evaluate inherent biases

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R Loops and Links to Human Disease

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A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

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p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

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Prenatal diagnosis of 1p34.3 interstitial microdeletion by aCGH in a fetus with jaw bone abnormalities

(2016) Themistoklis Dagklis et al.   Molecular Cytogenetics

RNase H enables efficient repair of R-loop induced DNA damage

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Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

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The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation

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PP2A–B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks

(2015) Xiuying Li et al.   TOXICOLOGY

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletion

(2015) Alexis Saintamand et al.   Nature Communications

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

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A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

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R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

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Self-assembled FUS binds active chromatin and regulates gene transcription

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Out of Balance: R-loops in Human Disease

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Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

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Tissue-specific dysregulation of DNA methylation in aging

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Crystal Structure of Human RNA Helicase A (DHX9): Structural Basis for Unselective Nucleotide Base Binding in a DEAD-Box Variant Protein

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Mammalian DEAD Box Protein Ddx51 Acts in 3' End Maturation of 28S rRNA by Promoting the Release of U8 snoRNA

(2010) L. Srivastava et al.   MOLECULAR AND CELLULAR BIOLOGY

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

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Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

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