Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletion

The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

(2015) Alexis Saintamand et al.   Oncotarget

Mantle cell lymphoma-like lymphomas in c-myc-3’RR/p53+/- mice and c-myc-3’RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin

(2015) Pauline Rouaud et al.   Oncotarget

AID-induced remodeling of immunoglobulin genes and B cell fate

(2015) Brice Laffleur et al.   Oncotarget

Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region

(2014) Pauline Rouaud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The E  Enhancer Region Influences H Chain Expression and B Cell Fate without Impacting IgVH Repertoire and Immune Response In Vivo

(2014) M. Marquet et al.   JOURNAL OF IMMUNOLOGY

AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination

(2014) Bharat Vaidyanathan et al.   Frontiers in Immunology

Flexible Long-Range Loops in the VH Gene Region of the Igh Locus Facilitate the Generation of a Diverse Antibody Repertoire

(2013) Jasna Medvedovic et al.   IMMUNITY

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

(2013) Pauline Rouaud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The cohesin complex regulates immunoglobulin class switch recombination

(2013) Anne-Sophie Thomas-Claudepierre et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells

(2013) Eric L Fritz et al.   NATURE IMMUNOLOGY

Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination

(2012) Jeremy A. Daniel et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1

(2012) Soo-Hyun Yang et al.   EMBO JOURNAL

Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination

(2012) Pauline Rouaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

AID targeting is dependent on RNA polymerase II pausing

(2012) Amy L. Kenter   SEMINARS IN IMMUNOLOGY

ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

(2011) Joanna I. Loizou et al.   CANCER CELL

Histone Deacetylase 9 Deficiency Protects against Effector T Cell-mediated Systemic Autoimmunity

(2011) Kailin Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylases 9 and 10 Are Required for Homologous Recombination

(2011) Shweta Kotian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

(2011) Beena Patricia Jeevan-Raj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes

(2010) C. Vincent-Fabert et al.   BLOOD

S-phase and DNA damage activated establishment of Sister chromatid cohesion—importance for DNA repair

(2010) Camilla Sjögren et al.   EXPERIMENTAL CELL RESEARCH

Distinct roles of HDAC1 and HDAC2 in transcription and recombination at the immunoglobulin loci in the chicken B cell line DT40

(2010) Kohei Kurosawa et al.   JOURNAL OF BIOCHEMISTRY

Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair

(2010) S. Kracker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

(2010) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

(2010) A. Stanlie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ig Synthesis and Class Switching Do Not Require the Presence of the hs4 Enhancer in the 3' IgH Regulatory Region

(2009) C. Vincent-Fabert et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

(2009) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination

(2009) F. L. Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: A post-cleavage role for AID

(2008) Hong Zan et al.   MOLECULAR IMMUNOLOGY