Review
Pharmacology & Pharmacy
Rebekah Omarkhail Elliott, Mei He
Summary: Exosomes, a subgroup of nanovesicles, have emerged as a key player in cellular communication, disease understanding, and drug delivery. Recent studies have highlighted the critical roles of exosomes in crossing various biological barriers, opening up new possibilities for their application as delivery platforms.
Review
Chemistry, Multidisciplinary
Pravin Shende, Riddhi Trivedi
Summary: Biofluids serve as valuable diagnostic tools for establishing disease profiles and monitoring patient progression, while also offering potential in the development of therapeutic drug delivery systems. This review highlights the properties and benefits of various biofluids, along with the therapeutic and targeting actions of fluid-derived substances in micro- or nano-systems. Biologically-oriented systems demonstrate advantages in natural origin, biocompatibility, and biodegradability, offering new techniques for overcoming challenges in conventional therapies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Physics, Multidisciplinary
Luigi Zanovello, Michele Caraglio, Thomas Franosch, Pietro Faccioli
Summary: The study shows that active Brownian particles reach the target more frequently and follow longer and counterintuitive search patterns compared to passive Brownian particles, leading to significant changes in the structure and kinetics of the ensemble of transition paths even in a simple landscape.
PHYSICAL REVIEW LETTERS
(2021)
Review
Pharmacology & Pharmacy
Thomas Secher, Nathalie Heuze-Vourc'h
Summary: This review discusses the barriers that can affect the fate of inhaled therapeutic antibodies (Abs) in the lungs, including both physical and biological barriers. It emphasizes the importance of considering the pathological changes during respiratory diseases which can intensify these barriers.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Immunology
Carolin Brandl, Laura Bucci, Georg Schett, Mario M. Zaiss
Summary: Maintaining immune balance and the role of gut microbiota in the pathogenesis of arthritis are crucial, while the integrity of the intestinal barrier function is essential to prevent the development of autoimmune diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Roger J. Narayan
Summary: The article discusses the potential of graphene as a drug delivery system to cross the blood-brain barrier, and how it can improve, protect, or rescue brain energetics, with a specific focus on how graphene alters neuronal cell function.
Review
Biochemistry & Molecular Biology
Andrew M. Hersh, Safwan Alomari, Betty M. Tyler
Summary: This article provides a review of the potential of nanoparticles (NPs) in improving drug delivery to brain tumors. The unique physical and chemical properties of NPs and the mechanisms of NP transport across the blood-brain barrier are discussed, along with the major types of NPs investigated for brain tumor treatment. In addition, the use of NPs as imaging contrast agents and their conjugation with imaging probes for visualization and treatment monitoring are explored. Finally, the limitations of NPs for brain tumor treatment are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jianbo Li, Yaru Xu, Jieke Zhang, Qinglian Li, Chenxu Wang, Zhe Wu, Weijing Yang, Meng Xu, Zhenzhong Zhang, Lei Wang, Jinjie Zhang
Summary: This study demonstrates the regulatory role of phospholipids in the rigidity of nanovehicles. By fine-tuning the rigidity of self-nanoemulsifying drug delivery system (SNEDDS) using insulin as a model drug, soft SNEDDS showed better performance in terms of oral delivery, with enhanced transcytosis, improved endocytosis, lysosome escape capability, and exocytosis. Rats with type 1 diabetes also exhibited greater oral insulin absorption and blood glucose lowering effect with soft SNEDDS.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Analytical
Hui Wang, Weili Wang, Qianqian Xie, Di Wu, Jiayu Cao, Huilin Chen, Meng Gao, Huizhen Zheng, Xi Liu, Jie Jiang, Wenjie Li, Xiaoming Cai, Sergey V. Gudkov, Ruibin Li
Summary: Fine particulates (FPs) are a major class of airborne pollutants that can have hazardous effects on mammals and birds. In this study, a library of 27 fluorescent nanoparticles (FNPs) was used to investigate the lung penetration of nanoparticles in chicken embryos. The size and surface charge of the nanoparticles were found to be key factors in determining their lung penetration capability. A predictive model was developed based on these findings to assess the respiratory risks of nanoproducts.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Etienne Lessard, Kerry Rennie, Arsalan Haqqani, Binbing Ling, James Whitfield, Andrea Paradis, Joseph Araujo, Nathan Yoganathan, John Gillard, Danica Stanimirovic, Balu Chakravarthy
Summary: This study demonstrates the translational attributes of the BBB-crossing A beta-targeting biotherapeutic KG207-H in eliciting a pharmacodynamic response, from rodents to larger animal species. The study compares the PK/PD of KG207-H in wild type rat and beagle dogs and shows similar serum pharmacokinetics and CNS exposure in both species.
PHARMACEUTICAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Olivia M. Turk, Ryan C. Woodall, Margarita Gutova, Christine E. Brown, Russell C. Rockne, Jennifer M. Munson
Summary: Cell-based therapies to the brain show promise for treating various brain disorders, but must overcome multiple physiological barriers. The blood-brain barrier has long been a major challenge for drug delivery, while other barriers may present specific challenges or opportunities for therapeutic delivery. Ongoing clinical trials using cell-based therapies to treat diseases, particularly cancers, have shown potential in treating some of the deadliest illnesses.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Virology
Fernando Merwaiss, Claudia Filomatori, Yasutsugu Susuki, Eugenia S. Bardossy, Diego E. Alvarez, Maria-Carla Saleh
Summary: This study investigates the interactions between CHIKV variants and anatomical barriers in Aedes mosquitoes, revealing that wild-type viruses have a higher transmission efficiency compared to 3'UTR mutant viruses, and high viral titers in the midgut are not sufficient to overcome the midgut escape barrier. Slowly replicating variants are less able to overcome the midgut escape barrier, indicating a link between CHIKV replication kinetics and population diversity.
JOURNAL OF VIROLOGY
(2021)
Review
Chemistry, Multidisciplinary
Luyao Wang, Youyuan Shi, Jingzhen Jiang, Chan Li, Hengrui Zhang, Xinhui Zhang, Tao Jiang, Liang Wang, Yinyan Wang, Lin Feng
Summary: The blood-brain barrier (BBB) poses a significant challenge for drug delivery to brain tumors. Recent research in micro- and nanotechnology has shown that nano drug-targeted delivery technologies have the potential to overcome this challenge. This review provides a detailed understanding of the BBB, summarizes recent research topics on drug delivery carriers for brain tumors, evaluates the effectiveness of targeted therapy, and discusses the challenges and future prospects of developing brain tumor drug delivery systems.
Article
Instruments & Instrumentation
Yuan Rui, Jordan J. Green
Summary: Glioblastoma remains one of the most deadly forms of primary adult tumors, with little improvement in prognosis over the past two decades. Cancer immunotherapy shows promise in treating glioblastoma, but faces unique challenges in drug delivery due to the blood-brain barrier and immune privileged status of the central nervous system. Recent advances in biomaterial-based strategies for cancer immunotherapy may offer potential solutions for effective treatment of glioblastoma.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Chemistry, Inorganic & Nuclear
Qiuxia Tan, Shaojing Zhao, Ting Xu, Qin Wang, Mei Zhang, Li Yan, Xianfeng Chen, Minhuan Lan
Summary: The blood-brain barrier (BBB) prevents external substances from entering the brain, making it difficult to treat central nervous system (CNS)-associated diseases. In recent years, inorganic nano-drug delivery systems (NDDS) have been developed to overcome this barrier and efficiently deliver drugs to the CNS. Various inorganic NDDS, such as metal-based nanoparticles, Si nanoparticles, Se nanoparticles, semiconductor quantum dots, and carbon nanostructures, have been explored. This review summarizes the progress and mechanisms of these inorganic NDDS in crossing the BBB, and discusses the factors that influence their efficacy.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Cell Biology
Wei Zhang, Li Ma, Mei Yang, Eric Shao, Jian Xu, Zhipeng Lu, Zhen Zhao, Rong Chen, Yang Chai, Jian-Fu Chen
GENES & DEVELOPMENT
(2020)
Article
Neurosciences
Kassandra Kisler, Angeliki M. Nikolakopoulou, Melanie D. Sweeney, Divna Lazic, Zhen Zhao, Berislav Zlokovic
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Geriatrics & Gerontology
Amy R. Nelson, Meghana A. Sagare, Yaoming Wang, Kassandra Kisler, Zhen Zhao, Berislav V. Zlokovic
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Psychiatry
Kate Hardy, Flint M. Espil, Christopher L. Smith, Adriana Furuzawa, Melanie Lean, Zhen Zhao, Julia Godzikovskaya, Al Gilbert, Rachel L. Loewy
Summary: Community clinicians in early psychosis programs can be trained to competence in CBTp after an initial didactic period and ongoing weekly group consultation. Staff turnover posed challenges to implementation, but 18 out of 40 clinicians achieved competency after an average of 54 weeks and six tape reviews.
EARLY INTERVENTION IN PSYCHIATRY
(2021)
Review
Physiology
Yingxi Wu, Haijian Wu, Xinying Guo, Brock Pluimer, Zhen Zhao
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mengfei Yu, Li Ma, Yuan Yuan, Xin Ye, Axel Montagne, Jinzhi He, Thach-Vu Ho, Yingxi Wu, Zhen Zhao, Naomi Sta Maria, Russell Jacobs, Mark Urata, Huiming Wang, Berislav Zlokovic, Jian-Fu Chen, Yang Chai
Summary: Craniosynostosis, caused by premature fusion of cranial sutures, poses a threat to human quality of life and health. Successful regeneration of cranial sutures using MSCs can correct skull deformities, improve intracranial pressure, and restore neurocognitive deficits.
Article
Immunology
Haijian Wu, Jingwei Zheng, Shenbin Xu, Yuanjian Fang, Yingxi Wu, Jianxiong Zeng, Anwen Shao, Ligen Shi, Jianan Lu, Shuhao Mei, Xiaoyu Wang, Xinying Guo, Yirong Wang, Zhen Zhao, Jianmin Zhang
Summary: Mer plays an important role in regulating microglial/macrophage M1/M2 polarization and neuroinflammation following TBI, potentially serving as a therapeutic target for intervention. Activation of the STAT1/SOCS1/3 pathway by Mer contributes to its regulatory function in this process.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Angeliki Maria Nikolakopoulou, Yaoming Wang, Qingyi Ma, Abhay P. Sagare, Axel Montagne, Mikko T. Huuskonen, Sanket V. Rege, Kassandra Kisler, Zhonghua Dai, Jakob Korbelin, Joachim Herz, Zhen Zhao, Berislav V. Zlokovic
Summary: Loss of LRP1 in endothelial cells leads to blood-brain barrier breakdown, neuronal loss, and cognitive deficits, which can be reversed by endothelial-specific LRP1 gene therapy. This effect is mediated by inhibiting cyclophilin A.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Meeting Abstract
Clinical Neurology
Angeliki M. Nikolakopoulou, Wang Yaoming, Dai Zhonghua, Mikko Huuskonen, Axel Montagne, Divna Lazic, Abhay Sagare, Zhao Zhen, John H. Griffin, Berislav Zlokovic
Article
Immunology
Jianxiong Zeng, Zhifei Luo, Shupeng Dong, Xiaochun Xie, Xinyan Liang, Youzhen Yan, Qiming Liang, Zhen Zhao
Summary: The study identified a complex interaction network between ZIKV-derived viRNAs and their viral RNA targets, demonstrating that viRNA production from ZIKV mRNA depends on Dicer function and is a limiting factor for ZIKV virulence in NSCs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao
Summary: This study demonstrates that microvascular injury plays a key role in the pathogenesis of Alzheimer's disease after mild traumatic brain injury. Restoring vascular functions may be beneficial for patients with mild TBI and potentially reduce the risk of developing AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Li Ma, Jing Wang, Jianlong Ge, Yuan Wang, Wei Zhang, Yuanning Du, Jun Luo, Yangping Li, Feng Wang, Guoping Fan, Rong Chen, Bing Yao, Zhen Zhao, Ming-Lei Guo, Woong-Ki Kim, Yang Chai, Jian-Fu Chen
Summary: This study demonstrates that ZIKV infection during pregnancy in mice leads to offspring displaying autistic-like behaviors, with abnormalities in neural circuits resulting in social memory deficits. The research highlights the importance of the vHIP-mPFC pathway in driving these behavioral abnormalities.
Article
Biochemistry & Molecular Biology
Guofang Shen, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma
Summary: CNP plays a vascular protective role in neonatal brain injury by reducing brain infarct size, decreasing brain edema and IgG extravasation, and protecting BMECs against oxygen-glucose deprivation. The vasculoprotective effect of CNP is mediated by its innate receptors NPR2 and NPR3, indicating a potential therapeutic target for neonatal brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Firoz Akhter, Alicia Persaud, Younis Zaokari, Zhen Zhao, Donghui Zhu
Summary: Vascular dementia (VaD) is a type of dementia caused by reduced blood flow to the brain, accounting for 20% of all dementia cases. There are subtle differences in the presentation of VaD between males and females, but they are often overlooked.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
