24‐Dehydrocholesterol reductase promotes the growth of breast cancer stem‐like cells through the Hedgehog pathway

GANT61 and curcumin-loaded PLGA nanoparticles for GLI1 and PI3K/Akt-mediated inhibition in breast adenocarcinoma

(2020) Ankita Borah et al.   NANOTECHNOLOGY

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

(2019) Rongxuan Zhu et al.   Nature Communications

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

(2019) Sidse Ehmsen et al.   Cell Reports

Gab2 promotes cancer stem cell like properties and metastatic growth of ovarian cancer via downregulation of miR-200c

(2019) Zenghui Fang et al.   EXPERIMENTAL CELL RESEARCH

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

(2019) Maia Kinnebrew et al.   eLife

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Identification of cancer-type specific expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in ALDEFLUOR assay

(2018) Lei Zhou et al.   CELL BIOLOGY AND TOXICOLOGY

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened

(2018) George Hedger et al.   STRUCTURE

Loss-of-function screens of druggable targetome against cancer stem–like cells

(2017) Mee Song et al.   FASEB JOURNAL

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

(2017) Xu Xiao et al.   MOLECULAR CELL

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

(2017) Yoshikazu Koike et al.   Breast Cancer

Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma

(2017) Miao Dai et al.   Scientific Reports

Targeting Androgen Receptor in Treating HER2 Positive Breast Cancer

(2017) Licai He et al.   Scientific Reports

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer

(2016) Amy E. Baek et al.   Hormones & Cancer

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

Decoding the phosphorylation code in Hedgehog signal transduction

(2013) Yongbin Chen et al.   CELL RESEARCH

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer stem cells and their role in metastasis

(2013) Yusuke Shiozawa et al.   PHARMACOLOGY & THERAPEUTICS

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

(2013) Eser J. Zerenturk et al.   PROGRESS IN LIPID RESEARCH

Cholesterol Forges Link Between Obesity and Breast Cancer

(2013) J. Kaiser   SCIENCE

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea

(2011) Cari M. Kitahara et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of DHCR24/Seladin-1 impairs cellular homeostasis in prostate cancer

(2010) Marie-Claude Battista et al.   PROSTATE

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer

(2008) Lorella Bonaccorsi et al.   LABORATORY INVESTIGATION