Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis

BMI and low vitamin D are causal factors for multiple sclerosis

(2020) Benjamin M. Jacobs et al.   Neurology-Neuroimmunology & Neuroinflammation

Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

(2020) Melissa M Gresle et al.   Life Science Alliance

Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Mitchell T Wallin et al.   LANCET NEUROLOGY

Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials

(2019) N Keum et al.   ANNALS OF ONCOLOGY

Vitamin D genes influence MS relapses in children

(2019) Jennifer S Graves et al.   Multiple Sclerosis Journal

Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis

(2019) Steve Simpson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Association between vitamin D supplementation and mortality: systematic review and meta-analysis

(2019) Yu Zhang et al.   BMJ-British Medical Journal

Cholecalciferol in relapsing-remitting MS: A randomized clinical trial (CHOLINE)

(2019) William Camu et al.   Neurology-Neuroimmunology & Neuroinflammation

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial

(2019) Arash Shirvani et al.   Scientific Reports

Vitamin D increases remyelination by promoting oligodendrocyte lineage differentiation

(2019) Ulises Gomez‐Pinedo et al.   Brain and Behavior

Vitamin D 3 supplementation and the IL-2/IL-2R pathway in multiple sclerosis: Attenuation of progressive disturbances?

(2018) Linda Rolf et al.   JOURNAL OF NEUROIMMUNOLOGY

Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes

(2018) Véréna Landel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The efficacy of vitamin D in multiple sclerosis: A meta-analysis

(2018) Chao Zheng et al.   Multiple Sclerosis and Related Disorders

Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial

(2018) Antonio J. Berlanga-Taylor et al.   EBioMedicine

Vitamin D for the treatment of multiple sclerosis: a meta-analysis

(2018) Laurie McLaughlin et al.   JOURNAL OF NEUROLOGY

Correlation of different cellular assays to analyze T cell-related cytokine profiles in vitamin D3-supplemented patients with multiple sclerosis

(2018) Linda Rolf et al.   MOLECULAR IMMUNOLOGY

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-dose vitamin D3 supplementation decreases the number of colonic CD103+ dendritic cells in healthy subjects

(2017) Nina Friis Bak et al.   EUROPEAN JOURNAL OF NUTRITION

1,25-Dihydroxyvitamin D 3 suppressed experimental autoimmune encephalomyelitis through both immunomodulation and oligodendrocyte maturation

(2017) Hasti Atashi Shirazi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Exploring the effect of vitamin D3 supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis

(2017) Linda Rolf et al.   Multiple Sclerosis Journal

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

(2017) Milena A. Gianfrancesco et al.   NEUROLOGY

25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort

(2017) Kassandra L. Munger et al.   NEUROLOGY

The expression of VDR mRNA but not NF-κB surprisingly decreased after vitamin D treatment in multiple sclerosis patients

(2017) Zeinab Shirvani-Farsani et al.   NEUROSCIENCE LETTERS

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Exploring the effect of vitamin D3 supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis

(2017) Linda Rolf et al.   Multiple Sclerosis Journal

The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells

(2016) T Berge et al.   GENES AND IMMUNITY

Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases

(2016) D R Booth et al.   GENES AND IMMUNITY

Vitamin D Supplementation Modulates T Cell–Mediated Immunity in Humans: Results from a Randomized Control Trial

(2016) Gauree Gupta Konijeti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Immune regulatory effects of high dose vitamin D3 supplementation in a randomized controlled trial in relapsing remitting multiple sclerosis patients receiving IFNβ; the SOLARIUM study

(2016) Anne-Hilde Muris et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein–Barr virus in relapsing-remitting multiple sclerosis

(2016) Egil Røsjø et al.   Multiple Sclerosis Journal

Neonatal vitamin D status and risk of multiple sclerosis

(2016) Nete Munk Nielsen et al.   NEUROLOGY

Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort

(2016) Kassandra L. Munger et al.   JAMA Neurology

Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein–Barr virus in relapsing-remitting multiple sclerosis

(2016) Egil Røsjø et al.   Multiple Sclerosis Journal

The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D

(2015) Veijo Nurminen et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Vitamin D supplementation up-regulates IL-6 and IL-17A gene expression in multiple sclerosis patients

(2015) Bahar Naghavi Gargari et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vitamin D3 administration to MS patients leads to increased serum levels of latency activated peptide (LAP) of TGF-beta

(2015) Julia Åivo et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of high dose vitamin D intake on interleukin-17 levels in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial

(2015) Nafiseh Toghianifar et al.   JOURNAL OF NEUROIMMUNOLOGY

Vitamin D supplementation and systemic inflammation in relapsing-remitting multiple sclerosis

(2015) Egil Røsjø et al.   JOURNAL OF NEUROLOGY

Interleukin-10 but not transforming growth factor-β1 gene expression is up-regulated by vitamin D treatment in multiple sclerosis patients

(2015) Zeinab Shirvani Farsani et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Vitamin D levels in multiple sclerosis patients: Association with TGF-β2, TGF-βRI, and TGF-βRII expression

(2015) Zeinab Shirvani-Farsani et al.   LIFE SCIENCES

Smoking is a major preventable risk factor for multiple sclerosis

(2015) AK Hedström et al.   Multiple Sclerosis Journal

Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls

(2015) Pavan Bhargava et al.   Multiple Sclerosis Journal

Population attributable fractions and joint effects of key risk factors for multiple sclerosis

(2015) IAF van der Mei et al.   Multiple Sclerosis Journal

Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2015) Fereshteh Ashtari et al.   NEUROIMMUNOMODULATION

Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis

(2015) Elias S. Sotirchos et al.   NEUROLOGY

1,25-Dihydroxyvitamin D3 Protects against Immune-Mediated Killing of Neurons in Culture and in Experimental Autoimmune Encephalomyelitis

(2015) Scott Sloka et al.   PLoS One

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

(2015) Lauren E. Mokry et al.   PLOS MEDICINE

Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b

(2015) Kathryn C. Fitzgerald et al.   JAMA Neurology

Smoking is a major preventable risk factor for multiple sclerosis

(2015) AK Hedström et al.   Multiple Sclerosis Journal

Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls

(2015) Pavan Bhargava et al.   Multiple Sclerosis Journal

Population attributable fractions and joint effects of key risk factors for multiple sclerosis

(2015) IAF van der Mei et al.   Multiple Sclerosis Journal

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

(2015) Karen Ann Ribbons et al.   PLoS One

25(OH)D2Half-Life Is Shorter Than 25(OH)D3Half-Life and Is Influenced by DBP Concentration and Genotype

(2014) K. S. Jones et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of Alfacalcidol on multiple sclerosis-related fatigue: A randomized, double-blind placebo-controlled study

(2014) Anat Achiron et al.   Multiple Sclerosis Journal

Patterns of Genome-Wide VDR Locations

(2014) Pauli Tuoresmäki et al.   PLoS One

Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression

(2014) Alberto Ascherio et al.   JAMA Neurology

High-dose cholecalciferol supplementation significantly increases peripheral CD4+ Tregs in healthy adults without negatively affecting the frequency of other immune cells

(2013) Barbara Prietl et al.   EUROPEAN JOURNAL OF NUTRITION

Oral vitamin D increases the frequencies of CD38+human B cells and ameliorates IL-17-producing T cells

(2013) Gennadiy Drozdenko et al.   EXPERIMENTAL DERMATOLOGY

Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

(2013) E. Peelen et al.   JOURNAL OF NEUROIMMUNOLOGY

Vitamin D supplementation and antibodies against the Epstein-Barr virus in multiple sclerosis patients

(2013) Giulio Disanto et al.   Multiple Sclerosis Journal

Fatty fish intake is associated with decreased occurrence of multiple sclerosis

(2013) Maria Bäärnhielm et al.   Multiple Sclerosis Journal

Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes

(2013) Vittorio Martinelli et al.   Multiple Sclerosis Journal

Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome

(2013) A. Langer-Gould et al.   NEUROLOGY

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

(2013) Arash Hossein-nezhad et al.   PLoS One

Preventive effect of vitamin D3 supplementation on conversion of optic neuritis to clinically definite multiple sclerosis: a double blind, randomized, placebo-controlled pilot clinical trial

(2012) Hajar Derakhshandi et al.   ACTA NEUROLOGICA BELGICA

Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis

(2012) Ellen M. Mowry et al.   ANNALS OF NEUROLOGY

Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?

(2012) Jinge Zhu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

(2012) E. D. Gorham et al.   DIABETOLOGIA

A randomised, double blind, placebo controlled trial with vitamin D3as an add on treatment to interferon β-1b in patients with multiple sclerosis

(2012) Merja Soilu-Hänninen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers

(2012) Aideen C Allen et al.   Multiple Sclerosis Journal

Effect of vitamin D3 supplementation on relapses, disease progression, and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial

(2012) Margitta T Kampman et al.   Multiple Sclerosis Journal

Vitamin D as a protective factor in multiple sclerosis

(2012) J. Salzer et al.   NEUROLOGY

Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis

(2012) T. F. Runia et al.   NEUROLOGY

Gestational vitamin D and the risk of multiple sclerosis in offspring

(2011) Fariba Mirzaei et al.   ANNALS OF NEUROLOGY

The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial

(2011) Gerlies Bock et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease

(2011) Ashwin N. Ananthakrishnan et al.   GASTROENTEROLOGY

Therapeutic Effect of Vitamin D3 in Multiple Sclerosis Patients

(2011) Ghasem Mosayebi et al.   IMMUNOLOGICAL INVESTIGATIONS

Cholecalciferol Plus Calcium Suppresses Abnormal PBMC Reactivity in Patients with Multiple Sclerosis

(2011) Samantha Kimball et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of vitamin D3 supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis

(2011) Stephanie Knippenberg et al.   Multiple Sclerosis Journal

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis

(2011) M. S. Stein et al.   NEUROLOGY

Sun exposure and vitamin D are independent risk factors for CNS demyelination

(2011) R. M. Lucas et al.   NEUROLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy

(2011) Sami Heikkinen et al.   NUCLEIC ACIDS RESEARCH

Plasma vitamin D and mortality in older men: a community-based prospective cohort study

(2010) Karl Michaëlsson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin D status is associated with relapse rate in pediatric-onset MS

(2010) Ellen M. Mowry et al.   ANNALS OF NEUROLOGY

Primary infection with the epstein-barr virus and risk of multiple sclerosis

(2010) Lynn I. Levin et al.   ANNALS OF NEUROLOGY

Higher 25-hydroxyvitamin D is associated with lower relapse risk in MS

(2010) Steve Simpson et al.   ANNALS OF NEUROLOGY

The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability

(2010) Antonio Scalfari et al.   BRAIN

A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution

(2010) S. V. Ramagopalan et al.   GENOME RESEARCH

Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects

(2010) Andreas P. Lysandropoulos et al.   JOURNAL OF NEUROIMMUNOLOGY

Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system

(2010) Femke Baeke et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The changing demographic pattern of multiple sclerosis epidemiology

(2010) Nils Koch-Henriksen et al.   LANCET NEUROLOGY

A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis

(2010) J. M. Burton et al.   NEUROLOGY

Safety and T Cell Modulating Effects of High Dose Vitamin D3 Supplementation in Multiple Sclerosis

(2010) Joost Smolders et al.   PLoS One

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

(2009) L. E. Jeffery et al.   JOURNAL OF IMMUNOLOGY

Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

(2009) Frederik Barkhof et al.   Nature Reviews Neurology

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

(2009) Sreeram V. Ramagopalan et al.   PLoS Genetics

25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population

(2008) M. L. Melamed et al.   ARCHIVES OF INTERNAL MEDICINE

1,25-dihydroxyvitamin D3promotes IL-10 production in human B cells

(2008) Guido Heine et al.   EUROPEAN JOURNAL OF IMMUNOLOGY