Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma

(2018) X C Li et al.   ANNALS OF ONCOLOGY

Disruption ofNSD1in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation

(2018) Nam Bui et al.   MOLECULAR CANCER THERAPEUTICS

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors

(2017) Mi Ni Huang et al.   GENOME RESEARCH

PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types

(2017) Jing Gong et al.   NUCLEIC ACIDS RESEARCH

Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia

(2017) Alvin W. T. Ng et al.   Science Translational Medicine

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

(2017) Jiang Chang et al.   Nature Communications

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

(2017) Eric Letouzé et al.   Nature Communications

Smoking, alcohol, and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people

(2017) Yuanjie Pang et al.   Cancer Medicine

Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis

(2016) Hai-De Qin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

signeR: an empirical Bayesian approach to mutational signature discovery

(2016) Rafael A. Rosales et al.   BIOINFORMATICS

GenVisR: Genomic Visualizations in R

(2016) Zachary L. Skidmore et al.   BIOINFORMATICS

Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies

(2016) Ye-Tao Wang et al.   BMC CANCER

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

(2016) Genta Sawada et al.   GASTROENTEROLOGY

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma

(2016) Jia-Jie Hao et al.   NATURE GENETICS

Mutational signatures associated with tobacco smoking in human cancer

(2016) L. B. Alexandrov et al.   SCIENCE

The topography of mutational processes in breast cancer genomes

(2016) Sandro Morganella et al.   Nature Communications

Effects of alcohol consumption, ALDH2 rs671 polymorphism, and Helicobacter pylori infection on the gastric cancer risk in a Korean population

(2016) Sarah Yang et al.   Oncotarget

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor

(2015) C. Dorr et al.   MOLECULAR CANCER RESEARCH

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

(2015) Nicholas McGranahan et al.   Science Translational Medicine

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

(2014) Ludmil B Alexandrov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

A comprehensive transcriptional portrait of human cancer cell lines

(2014) Christiaan Klijn et al.   NATURE BIOTECHNOLOGY

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

The UCSC Genome Browser database: 2015 update

(2014) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Genetic Variant of Single-Nucleotide Polymorphism Is Associated with Risk of Esophageal Squamous Cell Carcinoma

(2013) Bo Ye et al.   Genetic Testing and Molecular Biomarkers

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions

(2012) Chen Wu et al.   NATURE GENETICS

Association of Alcohol Intake With Pancreatic Cancer Mortality in Never Smokers

(2011) Susan M. Gapstur et al.   ARCHIVES OF INTERNAL MEDICINE

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations

(2011) Chen Wu et al.   NATURE GENETICS

A flexible R package for nonnegative matrix factorization

(2010) Renaud Gaujoux et al.   BMC BIOINFORMATICS

Functional Variants in ADH1B and ALDH2 Coupled With Alcohol and Smoking Synergistically Enhance Esophageal Cancer Risk

(2009) Ri Cui et al.   GASTROENTEROLOGY

Gene–environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population

(2009) Miyuki Tsuchihashi-Makaya et al.   HYPERTENSION RESEARCH

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics