Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides

Scalable Continuous Synthesis of Grignard Reagents from in Situ-Activated Magnesium Metal

(2020) Gabriele Menges-Flanagan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Automated Glycan Assembly: A Perspective

(2019) Mónica Guberman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

(2018) Melanie Trobe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

(2018) Ping Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

On-demand synthesis of organozinc halides under continuous flow conditions

(2018) Mateo Berton et al.   Nature Protocols

Regioselective ortho-functionalization of bromofluorenecarbaldehydes using TMPMgCl·LiCl

(2018) Dominik Göbel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselective Metalation and Functionalization of the Pyrazolo[1,5-a]pyridine Scaffold Using Mg- and Zn-TMP Bases

(2018) Moritz Balkenhohl et al.   ORGANIC LETTERS

Continuous Platform To Generate Nitroalkanes On-Demand (in Situ) Using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

(2018) Sergey V. Tsukanov et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

(2018) Damith Perera et al.   SCIENCE

Engineering chemistry for the future of chemical synthesis

(2018) D.E. Fitzpatrick et al.   TETRAHEDRON

Improving the Halogen-Magnesium Exchange by Using new Turbo-Grignard Reagents

(2018) Dorothée Sophia Ziegler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Controlling an organic synthesis robot with machine learning to search for new reactivity

(2018) Jarosław M. Granda et al.   NATURE

Reconfigurable system for automated optimization of diverse chemical reactions

(2018) Anne-Catherine Bédard et al.   SCIENCE

Generation and Cross-Coupling of Organozinc Reagents in Flow

(2018) Ananda Herath et al.   ORGANIC LETTERS

Amination of Phosphorodiamidate-Substituted Pyridines and Related N-Heterocycles with Magnesium Amides

(2018) Moritz Balkenhohl et al.   ORGANIC LETTERS

Organic synthesis in a modular robotic system driven by a chemical programming language

(2018) Sebastian Steiner et al.   SCIENCE

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

(2017) Lena Huck et al.   ORGANIC LETTERS

Zincation and Magnesiation of Functionalized Silylated Cyano­hydrins Using TMP-Bases

(2017) Paul Knochel et al.   SYNTHESIS-STUTTGART

An autonomous organic reaction search engine for chemical reactivity

(2017) Vincenza Dragone et al.   Nature Communications

Forbidden chemistries — paths to a sustainable future engaging continuous processing

(2017) Bernhard Gutmann et al.   Journal of Flow Chemistry

Facile Conversion of Red Phosphorus into Soluble Polyphosphide Anions by Reaction with Potassium Ethoxide

(2016) Alina Dragulescu-Andrasi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

(2016) Victor Sans et al.   CHEMICAL SOCIETY REVIEWS

Taming hazardous chemistry by continuous flow technology

(2016) M. Movsisyan et al.   CHEMICAL SOCIETY REVIEWS

Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material

(2016) Michael E. Kopach et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

Preparation of Grignard reagents from magnesium metal under continuous flow conditions and on-line monitoring by NMR spectroscopy

(2016) Michel Goldbach et al.   TETRAHEDRON LETTERS

Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

(2016) D. E. Fitzpatrick et al.   Reaction Chemistry & Engineering

The Logic of Automated Glycan Assembly

(2015) Peter H. Seeberger   ACCOUNTS OF CHEMICAL RESEARCH

Organic Synthesis: March of the Machines

(2015) Steven V. Ley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey

(2015) Robert Li-Yuan Bao et al.   CHEMICAL COMMUNICATIONS

Synthesis of a Precursor to Sacubitril Using Enabling Technologies

(2015) Shing-Hing Lau et al.   ORGANIC LETTERS

Synthesis of many different types of organic small molecules using one automated process

(2015) J. Li et al.   SCIENCE

4-(Phenylazo)diphenylamine (PDA): a universal indicator for the colorimetric titration of strong bases, Lewis acids, and hydride reducing agents

(2015) Shawn Blumberg et al.   TETRAHEDRON LETTERS

Rapid-flow synthesis of Zn—Qn complexes: Teaching old ligands new tricks with reactive Na2(HZnEt2)2

(2015) Levi Zane Miller et al.   Journal of Flow Chemistry

Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

(2014) Nerea Alonso et al.   ADVANCED SYNTHESIS & CATALYSIS

Strategies To Prepare and Use Functionalized Organometallic Reagents

(2014) Thomas Klatt et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous Reductions and Reductive Aminations Using Solid NaBH4

(2014) Kerry Gilmore et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

(2013) Lukas Kupracz et al.   ADVANCED SYNTHESIS & CATALYSIS

Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions

(2013) Asha Kadam et al.   GREEN CHEMISTRY

Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

(2013) Suzanne M. Opalka et al.   ORGANIC LETTERS

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

(2013) Philip R. D. Murray et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous organomagnesium synthesis of organometallic compounds

(2013) P. A. Storozhenko et al.   RUSSIAN JOURNAL OF APPLIED CHEMISTRY

Continuous synthesis of organomagnesium compounds

(2012) A. A. Grachev et al.   RUSSIAN JOURNAL OF APPLIED CHEMISTRY

Continuous proline catalysis via leaching of solid proline

(2011) Suzanne M Opalka et al.   Beilstein Journal of Organic Chemistry

Continuous Flow Organic Synthesis under High-Temperature/Pressure Conditions

(2010) Tahseen Razzaq et al.   Chemistry-An Asian Journal

Unmasking Representative Structures of TMP-Active Hauser and Turbo-Hauser Bases

(2008) Pablo García-Álvarez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

(2008) Jun-ichi Yoshida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regio- and Chemoselective Multiple Functionalization of Pyrimidine Derivatives by Selective Magnesiations using TMPMgCl·LiCl

(2008) Marc Mosrin et al.   ORGANIC LETTERS

Oxidative Amination of Cuprated Pyrimidine and Purine Derivatives

(2008) Nadège Boudet et al.   ORGANIC LETTERS

Preparation of Fully Substituted Anilines for the Synthesis of Functionalized Indoles

(2007) Armin H. Stoll et al.   ORGANIC LETTERS