High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog)

Epigenetics, cardiovascular disease, and cellular reprogramming

(2019) Keith Al-Hasani et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription

(2019) Nicole Steinbach et al.   NUCLEIC ACIDS RESEARCH

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

(2019) Yu-Ru Lee et al.   SCIENCE

5-Aza-2′-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter

(2019) Xi-Qian Xing et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Drug Design Targeting T-Cell Factor-Driven Epithelial–Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer

(2019) Adedoyin D. Abraham et al.   JOURNAL OF MEDICINAL CHEMISTRY

PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling—Brief Report

(2019) Sizhao Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epigenomes in Cardiovascular Disease

(2018) Manuel Rosa-Garrido et al.   CIRCULATION RESEARCH

Epigenetic modulation of vascular diseases: Assessing the evidence and exploring the opportunities

(2018) Gabriele G. Schiattarella et al.   VASCULAR PHARMACOLOGY

Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers

(2018) Michelle Lacey et al.   ATHEROSCLEROSIS

DNA methylation processes in atheosclerotic plaque

(2018) Einari Aavik et al.   ATHEROSCLEROSIS

Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy

(2017) Sheng-Chao Ma et al.   Molecular Medicine Reports

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis

(2017) Michael J. Bollong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice

(2017) Xueyun Huo et al.   Oncology Letters

The Yin–Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular RemodelingHighlights

(2016) Jianhui Zhuang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Smooth Muscle Cells

(2016) Mark W. Majesky   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4Novelty and Significance

(2016) Mark W. Majesky et al.   CIRCULATION RESEARCH

Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung

(2016) Xiuwu Zhang et al.   FREE RADICAL RESEARCH

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

(2016) Henrick Horita et al.   Nature Communications

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

(2015) Delphine Gomez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

DNA Methylation Map of Human Atherosclerosis

(2014) S. Zaina et al.   Circulation-Cardiovascular Genetics

Aberrant CpG island methylation of PTEN is an early event in nasopharyngeal carcinoma and a potential diagnostic biomarker

(2014) JINBANG LI et al.   ONCOLOGY REPORTS

DNA demethylation in the PTEN gene promoter induced by 5-azacytidine activates PTEN expression in the MG-63 human osteosarcoma cell line

(2014) DEYE SONG et al.   Experimental and Therapeutic Medicine

5-Aza-2′-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching

(2013) Yunye Ning et al.   ARCHIVES OF TOXICOLOGY

Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

(2013) Renjing Liu et al.   CIRCULATION

Concise Drug Review: Azacitidine and Decitabine

(2013) E. J. B. Derissen et al.   ONCOLOGIST

Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling

(2012) J. M. Spin et al.   CARDIOVASCULAR RESEARCH

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

(2011) Matthew R. Alexander et al.   Annual Review of Physiology

SDF-1α Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation

(2011) Raphael A. Nemenoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Restenosis after PCI. Part 1: pathophysiology and risk factors

(2011) J. Wouter Jukema et al.   Nature Reviews Cardiology

Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation

(2010) Seth B. Furgeson et al.   CARDIOVASCULAR RESEARCH

Targeted Deletion of PTEN in Smooth Muscle Cells Results in Vascular Remodeling and Recruitment of Progenitor Cells Through Induction of Stromal Cell–Derived Factor-1α

(2008) Raphael A. Nemenoff et al.   CIRCULATION RESEARCH