Protease-Activated Receptor-2 Decreased Zonula Occlidens-1 and Claudin-1 Expression and Induced Epithelial Barrier Dysfunction in Allergic Rhinitis

Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2

(2019) Mari Miki et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protease activated receptor-2 mediated upregulation of IL-17 receptor signaling on airway epithelial cells is responsible for neutrophilic infiltration during acute exposure of house dust mite allergens in mice

(2019) Ahmed Nadeem et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Epithelial physical barrier defects in chronic rhinosinusitis

(2019) Jian Jiao et al.   Expert Review of Clinical Immunology

Blocking histone deacetylase activity as a novel target for epithelial barrier defects in allergic rhinitis

(2019) Brecht Steelant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Neutrophil Elastase Induces MUC5AC Overexpression in Chronic Rhinosinusitis Through miR-146a

(2019) Danqing Yan et al.   American Journal of Rhinology & Allergy

MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis

(2018) I. Kortekaas Krohn et al.   ALLERGY

Effect of mite allergenic components on innate immune response: Synergy of protease (Group 1 & 3) and non-protease (Group 2 & 7) allergens

(2018) Sui-Chu Yin et al.   IMMUNOBIOLOGY

Associations of Current Wheeze and Body Mass Index with Perennial and Seasonal Allergic Rhinitis in Young Adults

(2018) Munehiro Matsumoto et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis

(2018) Brecht Steelant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients

(2018) Kazunari Sugita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Barrier dysfunction in the nasal allergy

(2018) Ayumi Fukuoka et al.   ALLERGOLOGY INTERNATIONAL

H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium

(2018) Tengfei Tian et al.   EXPERIMENTAL CELL RESEARCH

Recent advances in the diagnosis of allergic rhinitis

(2018) Xiangdong Wang et al.   Expert Review of Clinical Immunology

Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015)

(2016) Mei-Kwan Yau et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Proteinase activated receptor-2-mediated dual oxidase-2 up-regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma

(2015) Ahmed Nadeem et al.   IMMUNOLOGY

Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease

(2015) Kathryn L. Pothoven et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cigarette Smoke–Induced Disruption of Bronchial Epithelial Tight Junctions Is Prevented by Transforming Growth Factor-β

(2014) Andrea C. Schamberger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epithelial barrier function: At the front line of asthma immunology and allergic airway inflammation

(2014) Steve N. Georas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of Epithelial Cell Tight Junctions by Protease-Activated Receptor 2

(2014) Shuhei ENJOJI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Human airway trypsin-like protease induces mucin5AC hypersecretion via a protease-activated receptor 2-mediated pathway in human airway epithelial cells

(2013) Chunyi Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease

(2013) M D Hollenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

House dust mite allergen Der p 1 effects on sinonasal epithelial tight junctions

(2013) Oswaldo A. Henriquez et al.   International Forum of Allergy & Rhinology

The multi-faceted role of allergen exposure to the local airway mucosa

(2012) K. Golebski et al.   ALLERGY

Suppression of Connexin 26 is Related to Protease-Activated Receptor 2–Mediated Pathway in Patients with Allergic Rhinitis

(2012) Jing Zheng et al.   American Journal of Rhinology & Allergy

Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care

(2012) Philippe Jean Bousquet et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Regulation of Tight Junctions in Upper Airway Epithelium

(2012) Takashi Kojima et al.   Biomed Research International

Protease-activated receptor 2–dependent fluid secretion from airway submucosal glands by house dust mite extract

(2011) Hyung-Ju Cho et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

(2008) V. Shpacovitch et al.   JOURNAL OF LEUKOCYTE BIOLOGY