The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells

Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency

(2019) Peng Xu et al.   Stem Cell Research & Therapy

Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells

(2019) Haiping Zhang et al.   AGING CELL

APE1 deficiency promotes cellular senescence and premature aging features

(2018) Mengxia Li et al.   NUCLEIC ACIDS RESEARCH

Quality control guidelines for clinical-grade human induced pluripotent stem cell lines

(2018) Stephen Sullivan et al.   Regenerative Medicine

Identification of a cellularly active SIRT6 allosteric activator

(2018) Zhimin Huang et al.   Nature Chemical Biology

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

(2017) Maria Skamagki et al.   NATURE CELL BIOLOGY

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice

(2017) Wen Chen et al.   Cell Reports

Influence of donor age on induced pluripotent stem cells

(2016) Valentina Lo Sardo et al.   NATURE BIOTECHNOLOGY

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

(2016) Ronald A. McCord et al.   Aging-US

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

(2015) Zhu Xu et al.   CELL CYCLE

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

(2015) Jean-Pierre Etchegaray et al.   NATURE CELL BIOLOGY

Cell-based therapy technology classifications and translational challenges

(2015) Natalie M. Mount et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The aging signature: a hallmark of induced pluripotent stem cells?

(2013) Leili Rohani et al.   AGING CELL

The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

(2013) Amit Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Stem Cell Therapy to Cure Type 1 Diabetes: From Hype to Hope

(2013) Preeti Chhabra et al.   Stem Cells Translational Medicine

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

(2012) Z. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles

(2008) Massimiliano Cerletti et al.   CELL